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中华妇幼临床医学杂志(电子版) ›› 2024, Vol. 20 ›› Issue (05) : 504 -510. doi: 10.3877/cma.j.issn.1673-5250.2024.05.005

产科前沿专辑

组学分析在早产分子机制中的研究现状
费一鸣1, 刘卓1, 张丽娟1,()   
  1. 1.中国医科大学附属盛京医院妇产科,沈阳 110122
  • 收稿日期:2024-05-30 修回日期:2024-09-01 出版日期:2024-10-01
  • 通信作者: 张丽娟
  • 基金资助:
    国家自然科学基金项目(82371701)

Current research status of omics analysis in the molecular mechanism of preterm birth

Yiming Fei1, Zhuo Liu1, Lijuan Zhang1,()   

  1. 1.Department of Obstetrics and Gynecology,Shengjing Hospital of China Medical University,Shenyang 110122,Liaoning Province,China
  • Received:2024-05-30 Revised:2024-09-01 Published:2024-10-01
  • Corresponding author: Lijuan Zhang
引用本文:

费一鸣, 刘卓, 张丽娟. 组学分析在早产分子机制中的研究现状[J/OL]. 中华妇幼临床医学杂志(电子版), 2024, 20(05): 504-510.

Yiming Fei, Zhuo Liu, Lijuan Zhang. Current research status of omics analysis in the molecular mechanism of preterm birth[J/OL]. Chinese Journal of Obstetrics & Gynecology and Pediatrics(Electronic Edition), 2024, 20(05): 504-510.

孕龄为28~36+6 孕周分娩者,被定义为早产(preterm birth)。全球早产发生率为4%~16%,中国约为7%。早产儿易发生新生儿颅内出血、呼吸窘迫综合征等严重并发症。但是,早产的发生机制迄今尚未被临床阐明,预测及防治亦均尚无特别有效方法。越来越多学者利用组学技术研究早产发生机制,包括基因组学、微生物组学、转录组学、蛋白质组学、代谢组学等,发现了许多潜在相关基因、作用机制及母体生物学标志物,如CPPED1 基因、Wnt信号通路及胎儿纤维连接蛋白(f FN)。笔者拟聚焦早产分子机制的相关组学研究,包括基因组学、微生物组学、转录组学、蛋白质组学、代谢组学等,在早产分子机制中的最新研究现状进行阐述,旨在为早产的临床预测及诊疗提供理论参考。

Those who give birth with a gestational age of 28-36+6 weeks of gestation are defined as preterm birth.The incidence of preterm birth in countries around the world is 4%-16%,and about 7%in China.Premature infants are prone to serious complications such as neonatal intracranial hemorrhage and neonatal respiratory d istress syndrome.However,the mechanism of preterm birth has not been clinically elucidated,and there is no particularly effective method for prediction and prevention.More and more scholars are using omics to study the mechanism of preterm birth,including genomics,microbiomics,transcriptomics,proteomics,metabolomics,etc.,and have discovered many potential related genes,mechanisms of action and maternal biomarkers,such as CPPED1 gene,Wnt signaling pathway and fetal fibronectin (f FN).The authors intend to focus on the latest research status of omics research related to the molecular mechanism of preterm birth,including genomics,microbiomics,transcriptomics,proteomics,metabolomics,etc.,aiming to provide a theoretical reference for the clinical prediction and diagnosis and treatment of preterm birth.

表1 不同组学技术在早产中的相关研究
[1]
魏玉梅, 杨慧霞.我国早产定义下限值设定的相关问题与争议[J].中国实用妇科与产科杂志,2023,39(2):129-130.DOI:10.19538/j.fk2023020101.Wei YM,Yang HX.Issues and controversies related to the setting of the lower limit of the definition of preterm birth in China[J].Chin J Pract Gynecol Obstet,2023,39(2):129-130.DOI:10.19538/j.fk2023020101.
[2]
Stanfield Z,Lai PF,Lei K,et al.Corrigendum:myometrial transcriptional signatures of human parturition[J].Front Genet,2019,10:515.DOI:10.3389/fgene.2019.00515.
[3]
徐佳惠, 卢莎, 胡文胜.组学技术在妊娠期高血压疾病发病机制及预测研究中的应用进展[J].预防医学,2023,35(1):36-40.DOI:10.19485/j.cnki.issn2096-5087.2023.01.008.Xu JH,Lu S,Hu WS.Application of omics in the pathogenesis and prediction of hypertensive disorders of pregnancy:a review[J].J Prev Med,2023,35(1):36-40.DOI:10.19485/j.cnki.issn2096-5087.2023.01.008.
[4]
Romero R,Espinoza J,Gotsch F,et al.The use of highdimensional biology (genomics,transcriptomics,proteomics,and metabolomics)to understand the preterm parturition syndrome[J].BJOG:Int J Obstet Gy,2006,113(Supppl 3):118-135.DOI:10.1111/j.1471-0528.2006.01150.x.
[5]
Jain VG,Monangi N,Zhang G,et al.Genetics,epigenetics,and transcriptomics of preterm birth[J].Am J Reprod Immunol,2022,88(4):e13600.DOI:10.1111/aji.13600.
[6]
Lapehn S,Paquette AG.The placental epigenome as a molecular link between prenatal exposures and fetal health outcomes through the DOHaD hypothesis[J].Curr Environ Health Rep,2022,9(3):490-501.DOI:10.1007/s40572-022-00354-8.
[7]
Merid SK,Novoloaca A,Sharp GC,et al.Epigenome-wide meta-analysis of blood DNA methylation in newborns and children identifies numerous loci related to gestational age[J].Genome Med,2020,12(1):25.DOI:10.1186/s13073-020-0716-9.
[8]
Collier AY,Ledyard R,Montoya-Williams D,et al.Racial and ethnic representation in epigenomic studies of preterm birth:a systematic review[J].Epigenomics,2020,13(21):1735-1746.DOI:10.2217/epi-2020-0007.
[9]
Akram KM,Kulkarni NS,Brook A,et al.Transcriptomic analysis of the human placenta reveals trophoblast dysfunction and augmented Wnt signalling associated with spontaneous preterm birth[J].Front Cell Dev Biol,2022,10:987740.DOI:10.3389/fcell.2022.987740.
[10]
Brockway H M,Kallapur SG,Buhimschi IA,et al.Unique transcriptomic landscapes identified in idiopathic spontaneous and infection related preterm births compared to normal term births[J].PLoS One,2019,14(11):e0225062.DOI:10.1371/journal.pone.0225062.
[11]
Li A,Zhang L,Liu Q,et al.Proteomic analysis of amniotic fluid to identify potential targets predicting preterm delivery[J].Biochim Biophys Acta Proteins Proteom,2023,1871(2):140879.DOI:10.1016/j.bbapap.2022.140879.
[12]
Wang Pr,Pan J,Tian Xj,et al.Transcriptomics-determined chemokine-cytokine pathway presents a common pathogenic mechanism in pregnancy loss and spontaneous preterm birth[J].Am J Reprod Immunol,2021,86(1):e13398.DOI:10.1111/aji.13398.
[13]
Wikström T,Abrahamsson S,Bengtsson-Palme J,et al.Microbial and human transcriptome in vaginal fluid at midgestation:association with spontaneous preterm delivery[J].Clin Transl Med,2022,12(9):e1023.DOI:10.1002/ctm2.1023.
[14]
Vora N,Parker J,Mieckowski P,et al.RNA-sequencing of umbilical cord blood to investigate spontaneous preterm birth:a pilot study[J].Am J Perinat Rep,2019,9(1):e60-e66.DOI:10.1055/s-0039-1678717.
[15]
Lamont RF,Richardson LS,Boniface JJ,et al.Commentary on a combined approach to the problem of developing biomarkers for the prediction of spontaneous preterm labor that leads to preterm birth[J].Placenta,2020,98:13-23.DOI:10.1016/j.placenta.2020.05.007.
[16]
Hsu TY,Tsai KW,Lan KC,et al.Identifying the potential protein biomarkers of preterm birth in amniotic fluid[J].Taiwan J Obstet Gyne,2020,59(3):366-371.DOI:10.1016/j.tjog.2020.03.005.
[17]
Parry S,Leite R,Esplin MS,et al.Cervicovaginal fluid proteomic analysis to identify potential biomarkers for preterm birth[J].Am J Obstet Gynecol,2020,222(5):493.e491-493.e413.DOI:10.1016/j.ajog.2019.11.1252.
[18]
Lee JE,Park KH,Kim HJ,et al.Proteomic identification of novel plasma biomarkers associated with spontaneous preterm birth in women with preterm labor without infection/inflammation[J].PLoS One,2021,16(10):e0259265.DOI:10.1371/journal.pone.0259265.
[19]
Hong S,Lee JE,Kim YM,et al.Identifying potential biomarkers related to pre-term delivery by proteomic analysis of amniotic fluid[J].Sci Rep,2020,10(1):19648.DOI:10.1038/s41598-020-76748-1.
[20]
Hallingström M,ZedníkováP,Tambor V,et al.Midtrimester amniotic fluid proteome's association with spontaneous preterm delivery and gestational duration[J].PLoS One,2020,15(5):e0232553.DOI:10.1371/journal.pone.0232553.
[21]
Tiensuu H,Haapalainen AM,Tissarinen P,et al.Human placental proteomics and exon variant studies link AAT/SERPINA1 with spontaneous preterm birth[J].BMC Med,2022,20(1):141.DOI:10.1186/s12916-022-02339-8.
[22]
Morillon AC,Yakkundi S,Thomas G,et al.Association between phospholipid metabolism in plasma and spontaneous preterm birth:a discovery lipidomic analysis in the cork pregnancy cohort[J].Metabolomics,2020,16(2):19.DOI:10.1007/s11306-020-1639-6.
[23]
Aung MT,Ashrap P,Watkins DJ,et al.Maternal lipidomic signatures in relation to spontaneous preterm birth and largefor-gestational age neonates[J].Sci Rep,2021,11(1):8115.DOI:10.1038/s41598-021-87472-9.
[24]
刘晓婷, 张立文, 王成彬.羊水代谢组学在早产母胎医学中的研究进展[J].解放军医学院学报,2019,40(9):834-836.DOI:10.3969/j.issn.2095-5227.2019.09.007.Liu XT,Zhang LW,Wang CB.Research advances in amniotic fluid metabolomics in maternal-fetal medicine of preterm labor[J].Acad J Chin PLA Med Sch,2019,40(9):834-836.DOI:10.3969/j.issn.2095-5227.2019.09.007.
[25]
Souza RT,Galvão RB,Leite DFB,et al.Use of metabolomics for predicting spontaneous preterm birth in asymptomatic pregnant women:protocol for a systematic review and meta-analysis[J].BMJ Open,2019,9(3):e026033.DOI:10.1136/bmjopen-2018-026033.
[26]
Elshenawy S,Pinney SE,Stuart T,et al.The metabolomic signature of the placenta in spontaneous preterm birth[J].Int J Mol Sci,2020,21(3):1043.DOI:10.3390/ijms 21031043.
[27]
Gupta Juhi K,Care A,Goodfellow L,et al.Metabolic profiling of maternal serum of women at high-risk of spontaneous preterm birth using NMR and MGWAS approach[J].Biosci Rep,2021,41(9):BSR20210759.DOI:10.1042/bsr20210759.
[28]
Tan Y,Barr DB,Ryan PB,et al.High-resolution metabolomics of exposure to tobacco smoke during pregnancy and adverse birth outcomes in the Atlanta African American maternal-child cohort[J].Environ Pollut,2022,292(Pt A):118361.DOI:10.1016/j.envpol.2021.118361.
[29]
Kumar PS.Microbiomics:were we all wrong before? [J].Periodontol,2000,2021,85(1):8-11.DOI:10.1111/prd.12373.
[30]
Fettweis JM,Serrano MG,Brooks JP,et al.The vaginal microbiome and preterm birth[J].Nat Med,2019,25(6):1012-1021.DOI:10.1038/s41591-019-0450-2.
[31]
You YA,Kwon EJ,Choi SJ,et al.Vaginal microbiome profiles of pregnant women in Korea using a 16S metagenomics approach[J].Am J Reprod Immunol,2019,82(1):e13124.DOI:10.1111/aji.13124.
[32]
袁晓瑞, 谭延林, 符淳.上皮性卵巢癌患者淋巴结转移预测模型的构建:基于18F-氟代脱氧葡萄糖正电子发射计算机体层摄影-CT 影像组学技术[J].中国全科医学,2024:1-8.DOI:10.12114/j.issn.1007-9572.2023.0484.Yuan XR,Tan YL,Fu C.Construction of the predictive model for lymph node metastasis in patients with epithelial ovarian cancer:based on 18F-FDG PET/CT radiomics technology[J].Chin Gen Pract,2024:1-8.DOI:10.12114/j.issn.1007-9572.2023.0484.
[33]
Skrede OJ,De Raedt S,Kleppe A,et al.Deep learning for prediction of colorectal cancer outcome:a discovery and validation study[J].Lancet,2020,395(10221):350-360.DOI:10.1016/S0140-6736(19)32998-8.
[34]
Wang W,Zhang JC,Tian WS,et al.Shear wave elastography-based ultrasomics:differentiating malignant from benign focal liver lesions[J].Abdom Radiol,2020,46(1):237-248.DOI:10.1007/s00261-020-02614-3.
[35]
Du Y,Fang Z,Jiao J,et al.Application of ultrasound-based radiomics technology in fetal-lung-texture analysis in pregnancies complicated by gestational diabetes and/or preeclampsia[J].Ultrasound Obstet Gynecol,2021,57(5):804-812.DOI:10.1002/uog.22037.
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