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中华妇幼临床医学杂志(电子版) ›› 2020, Vol. 16 ›› Issue (03) : 249 -256. doi: 10.3877/cma.j.issn.1673-5250.2020.03.001

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全民健康助力全面小康

新生儿胎粪吸入综合征的防治研究现状
刘莉1, 唐军1,†()   
  1. 1. 四川大学华西第二医院新生儿科、出生缺陷与相关妇儿疾病教育部重点实验室，成都　610041
  • 收稿日期:2020-02-22 修回日期:2020-05-09 出版日期:2020-06-01
  • 通信作者: 唐军

Current status of prevention and treatment of neonatal meconium aspiration syndrome

Li Liu1, Jun Tang1,†()   

  1. 1. Department of Pediatrics, Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China
  • Received:2020-02-22 Revised:2020-05-09 Published:2020-06-01
  • Corresponding author: Jun Tang
  • About author:
    Corresponding author: Tang Jun, Email:
  • Supported by:
    National Natural Science Foundation of China(81300524, 81630038, 81771643, 81971433, 81971428); National Major Program of Ministry of Science and Technology of China(2017YFA0104200); Fund of National Clinical Key Specialties Development (Neonatology)(1311200003303); Science and Technology Planning Project of Science and Technology Department of Sichuan Province(2016TD0002)
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刘莉, 唐军. 新生儿胎粪吸入综合征的防治研究现状[J/OL]. 中华妇幼临床医学杂志(电子版), 2020, 16(03): 249-256.

Li Liu, Jun Tang. Current status of prevention and treatment of neonatal meconium aspiration syndrome[J/OL]. Chinese Journal of Obstetrics & Gynecology and Pediatrics(Electronic Edition), 2020, 16(03): 249-256.

新生儿胎粪吸入综合征(MAS)是一种威胁新生儿生命的呼吸系统疾病，导致的新生儿死亡率高。MAS可导致新生儿出现呼吸衰竭、气漏综合征、持续肺动脉高压、多脏器功能损伤等严重并发症。随着近年围生技术的发展，MAS诊治手段不断提高，从而使该病患儿存活率增高。笔者拟就MAS的最新防治研究现状进行阐述，旨在探讨对MAS患儿的产前、产时处理及产后新生儿呼吸道管理、药物治疗、呼吸支持治疗、吸入一氧化氮(iNO)、体外膜肺氧合(ECMO)技术、亚低温治疗等相关措施，对MAS患儿预后的影响。

关键词: 胎粪吸入综合征, 肺表面活性物质相关蛋白质类, 一氧化氮, 投药，吸入, 低温，人工, 连续气道正压通气, 体外膜肺氧合, 婴儿，新生

Neonatal meconium aspiration syndrome (MAS) is a life-threatening respiratory disease with high mortality. MAS can lead to respiratory failure, air leakage syndrome, persistent pulmonary hypertension, multiple organ function damage and other serious complications. In recent years, with the development of perinatal technology, the diagnosis and treatment of MAS has been continuously improved, thus increasing the survival rate of children with MAS. The authors intend to review the latest research status of prevention and treatment of MAS, in order to explore the effects of prenatal and intrapartum management, drug therapy, respiratory support therapy, inhaled nitric oxide (iNO), technology of extracorporeal membrane oxygenation (ECMO), mild hypothermia therapy and other related measures on the prognosis of children with MAS.

Key words: Meconium aspiration syndrome, Pulmonary surfactant-associated proteins, Nitric oxide, Administration, inhalation, Hypothermia, induced, Continuous positive airway pressure, Extracorporeal membrane oxygenation, Infant, newborn
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