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中华妇幼临床医学杂志(电子版) ›› 2018, Vol. 14 ›› Issue (01) : 109 -112. doi: 10.3877/cma.j.issn.1673-5250.2018.01.018

所属专题: 文献

综述

血管性血友病因子在子痫前期发病机制中的研究进展
陈晓娟1, 卢丹2,(), 蒋敏2   
  1. 1. 116044 辽宁,大连医科大学
    2. 225009 江苏,扬州大学临床医学院
  • 收稿日期:2017-10-15 修回日期:2018-01-07 出版日期:2018-02-01
  • 通信作者: 卢丹

Research progress of von Willebrand factor in the pathogenesis of pre-eclampsia

Xiaojuan Chen1, Dan Lu2,(), Min Jiang2   

  1. 1. Dalian Medical University, Dalian 116044, Liaoning Province, China
    2. Clinical Medicine School of Yangzhou University, Yangzhou 225009, Jiangsu Province, China
  • Received:2017-10-15 Revised:2018-01-07 Published:2018-02-01
  • Corresponding author: Dan Lu
  • About author:
    Corresponding author: Lu Dan, Email:
引用本文:

陈晓娟, 卢丹, 蒋敏. 血管性血友病因子在子痫前期发病机制中的研究进展[J/OL]. 中华妇幼临床医学杂志(电子版), 2018, 14(01): 109-112.

Xiaojuan Chen, Dan Lu, Min Jiang. Research progress of von Willebrand factor in the pathogenesis of pre-eclampsia[J/OL]. Chinese Journal of Obstetrics & Gynecology and Pediatrics(Electronic Edition), 2018, 14(01): 109-112.

子痫前期(PE)是妊娠期特发的高血压疾病,可伴有脑、心、肝、肾等多器官损害,是导致孕产妇及围生儿病死率和死亡率升高的主要原因。目前,PE的发病机制虽尚未完全阐明,但是临床一致认为,PE患者病情加重时必须及时终止妊娠。由此可见,了解PE的发病机制,早期预防和治疗PE具有重要的临床意义。血管性血友病因子(vWF)是内皮细胞损伤的重要标志物,文献报道,vWF与PE可能具有一定相关性。笔者拟就vWF在PE发病机制中的作用进行综述。

Pre-eclampsia (PE) is an idiopathic hypertensive disease which frequently appear during pregnancy, and it is accompanied with multiple systemic damages such as brain, heart, liver, kidney, etc.. PE is the main cause of the increase of maternal and perinatal morbidity and mortality. At present, the exploration of the specific pathogenesis of PE is still unclear, but it is certain that when PE continues to deteriorate, it can only be improved by terminating the pregnancy timely. So understanding the pathogenesis of PE, preventing and treating PE in early stage is of great significance. von willebrand factor (vWF) is an important marker of endothelial cell injury, while domestic and overseas studies have shown that vWF may associate with PE. This paper makes a review about the roles of vWF in the pathogenesis of PE.

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