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中华妇幼临床医学杂志(电子版) ›› 2017, Vol. 13 ›› Issue (06) : 627 -632. doi: 10.3877/cma.j.issn.1673-5250.2017.06.002

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环境内分泌干扰物双酚A与多囊卵巢综合征的相关性研究
唐露1, 聂颖2, 刘琦2, 胡颖3, 许良智3,()   
  1. 1. 610041 成都,四川大学华西第二医院妇产科、出生缺陷与相关妇儿疾病教育部重点实验室;610041 成都,四川大学华西临床医学院
    2. 610041 成都,四川大学华西临床医学院
    3. 610041 成都,四川大学华西第二医院妇产科、出生缺陷与相关妇儿疾病教育部重点实验室
  • 收稿日期:2017-07-03 修回日期:2017-09-28 出版日期:2017-12-01
  • 通信作者: 许良智

Research of association between environmental endocrine disruptor bisphenol A and polycystic ovary syndrome

Lu Tang1, Ying Nie2, Qi Liu2, Ying Hu3, Liangzhi Xu3,()   

  1. 1. Department of Gynecology and Obstetrics, Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China; West China Medical School of Sichuan University, Chengdu 610041, Sichuan Province, China
    2. West China Medical School of Sichuan University, Chengdu 610041, Sichuan Province, China
    3. Department of Gynecology and Obstetrics, Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China
  • Received:2017-07-03 Revised:2017-09-28 Published:2017-12-01
  • Corresponding author: Liangzhi Xu
  • About author:
    Corresponding author: Xu Liangzhi, Email:
引用本文:

唐露, 聂颖, 刘琦, 胡颖, 许良智. 环境内分泌干扰物双酚A与多囊卵巢综合征的相关性研究[J]. 中华妇幼临床医学杂志(电子版), 2017, 13(06): 627-632.

Lu Tang, Ying Nie, Qi Liu, Ying Hu, Liangzhi Xu. Research of association between environmental endocrine disruptor bisphenol A and polycystic ovary syndrome[J]. Chinese Journal of Obstetrics & Gynecology and Pediatrics(Electronic Edition), 2017, 13(06): 627-632.

多囊卵巢综合征(PCOS)是常见的妇科内分泌疾病,在育龄期妇女中的发病率为5%~10%。PCOS病因复杂,已有研究结果表明,PCOS的发生与非遗传因素中的环境因素有关。双酚A是典型的环境内分泌干扰物(EED)之一,日常生活中,被广泛应用于矿泉水瓶、食品包装等塑料制品中。双酚A具有弱雌激素和抗雄激素等活性。相关流行病学和基础实验研究结果表明,双酚A暴露可能参与PCOS的发生、发展。目前关于双酚A与PCOS之间的潜在生物学机制,尚需进一步阐明。笔者拟整合近年国内外相关文献,对双酚A与PCOS相关性的研究进展进行阐述,旨在为临床预防和治疗PCOS寻找可靠的方法和依据。

Polycystic ovary syndrome (PCOS) is a common disease in the field of gynecological endocrinology, and the incidence of PCOS in reproductive age is 5%-10%. Etiology of PCOS is complex, and accumulated evidence has shown that, the occurrence of PCOS is associated with environmental factors. Bisphenol A is one of the typical environmental endocrine disruptors (EED), which is widely used in daily plastic products, such as mineral water bottles, foods packaging, etc.. Bisphenol A has weak estrogenic and anti-androgenic activity. Relevant epidemiology and basic experimental studies have shown that bisphenol A exposure may be involved in the occurrence and development of PCOS. The current potential biological mechanism between bisphenol A and PCOS needs to be elucidated. In this article, the authors intend to review the domestic and foreign literatures on the association between environmental endocrine disruptor bisphenol A and PCOS, to find reliable methods and basis for the prevention and treatment of PCOS.

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