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中华妇幼临床医学杂志(电子版) ›› 2022, Vol. 18 ›› Issue (05) : 506 -511. doi: 10.3877/cma.j.issn.1673-5250.2022.05.002

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复发性流产与肠道微生物群失衡
孙环蕊1, 张若鹏2,3,()   
  1. 1大理大学临床医学院,大理 671000
    2大理大学第一附属医院生殖医学科,大理 671000
    3昆明市妇幼保健院,昆明 650000
  • 收稿日期:2022-02-03 修回日期:2022-09-09 出版日期:2022-10-01
  • 通信作者: 张若鹏

Recurrent spontaneous abortion and the imbalance of gut microbiota

Huanrui Sun1, Ruopeng Zhang2,3,()   

  1. 1Clinic School of Medicine, Dali University, Dali 671000, Yunnan Province, China
    2Department of Reproductive Medicine, The First Affiliated Hospital of Dali University, Dali 671000, Yunnan Province, China
    3Kunming Maternal and Child Health Hospital, Kunming 650000, Yunnan Province, China
  • Received:2022-02-03 Revised:2022-09-09 Published:2022-10-01
  • Corresponding author: Ruopeng Zhang
  • Supported by:
    National Natural Science Foundation of China(81860271); Famous Doctors and Masters Talents Project of " Ten Thousand Talents Program" in Yunnan Province([2019]35); Eighth Batch of Young and Middle-aged Academic Leaders Reserve Talents Project of Dali University([2017]2)
引用本文:

孙环蕊, 张若鹏. 复发性流产与肠道微生物群失衡[J/OL]. 中华妇幼临床医学杂志(电子版), 2022, 18(05): 506-511.

Huanrui Sun, Ruopeng Zhang. Recurrent spontaneous abortion and the imbalance of gut microbiota[J/OL]. Chinese Journal of Obstetrics & Gynecology and Pediatrics(Electronic Edition), 2022, 18(05): 506-511.

复发性流产(RSA)是一种多病因疾病。肠道微生物群失衡已被证实与多种疾病的发生、发展有关,包括肥胖、多囊卵巢综合征(PCOS)、糖尿病、自身免疫性甲状腺疾病(AITD)、抑郁症等,而上述疾病皆为导致RSA发生的病因,由此间接提示RSA可能与肠道微生物群失衡有关。肠道微生物群失衡导致RSA的发病机制迄今尚未完全阐明。笔者拟对①RSA的流行病学及病因;②肠道微生物群失衡对机体的影响;③RSA病因与肠道微生物群失衡的最新研究进展等进行阐述,旨在为RSA诊治提供新的方向。

Recurrent spontaneous abortion (RSA) is a multi-causal disease. The imbalance of gut microbiota has been confirmed to be related to the occurrence and development of various diseases, including obesity, polycystic ovary syndrome (PCOS), diabetes, autoimmune thyroid disease (AITD), depression, etc., all of which can lead to RSA. The etiological factors of RSA indirectly suggest that RSA may be related to gut microbiota imbalance. The pathogenesis of gut microbiota imbalance leading to RSA has not yet been fully elucidated. The author intends to elaborate on the latest researches of epidemiology and etiology of RSA, impacts of gut microbiota imbalance on the body, and etiology of RSA and gut microbiota imbalance, aiming to provide a new direction for diagnosis and treatment of RSA.

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