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中华妇幼临床医学杂志(电子版) ›› 2022, Vol. 18 ›› Issue (05) : 497 -505. doi: 10.3877/cma.j.issn.1673-5250.2022.05.001

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支气管肺发育不良及肺动脉高压有关信号通路研究现状
伏洪玲, 刘瀚旻†()   
  1. 四川大学华西第二医院儿科、出生缺陷与相关妇儿疾病教育部重点实验室、西部妇幼医学研究院血管重构与发育缺陷研究室，成都　610041
  • 收稿日期:2021-11-30 修回日期:2022-07-30 出版日期:2022-10-01
  • 通信作者: 刘瀚旻

Research progress on signaling pathways involved in bronchopulmonary dysplasia and pulmonary hypertension

Hongling Fu, Hanmin Liu†()   

  1. Department of Pediatrics, Key Laboratory of Birth Defects and Related Disease of Women and Children (Sichuan University), Ministry of Education, Vascular Remodeling and Developmental Defects Research Unit of West China Institutes for Women and Children′s Health, West China Second University Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China
  • Received:2021-11-30 Revised:2022-07-30 Published:2022-10-01
  • Corresponding author: Hanmin Liu
  • Supported by:
    National Key Research and Development Program of China(2017YFC0211705)
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伏洪玲, 刘瀚旻. 支气管肺发育不良及肺动脉高压有关信号通路研究现状[J]. 中华妇幼临床医学杂志(电子版), 2022, 18(05): 497-505.

Hongling Fu, Hanmin Liu. Research progress on signaling pathways involved in bronchopulmonary dysplasia and pulmonary hypertension[J]. Chinese Journal of Obstetrics & Gynecology and Pediatrics(Electronic Edition), 2022, 18(05): 497-505.

支气管肺发育不良(BPD)是早产儿的主要并发症之一。中至重度BPD患儿中，约25%可能并发BPD相关肺动脉高压(PH)，是影响BPD患儿病死率增高及后期生存质量降低的主要原因。目前针对上述BPD及其相关PH的预防与治疗方法尚有限，因此深入研究其发病机制，进而进行针对性有效治疗刻不容缓。近年研究发现，在BPD及其相关PH发生、发展过程中，许多相关信号通路存在异常，如血管生成素(Ang)、血管内皮生长因子(VEGF)、转化生长因子(TGF)-β、Wnt、结缔组织生长因子(CTGF)、成纤维细胞生长因子(FGF)10、微小RNA(miRNA)、小窝蛋白(Cav)-1信号通路等，这些加深了临床对BPD及其相关PH发病机制的理解，并为其治疗提供了新思路。笔者拟就BPD及其相关PH所涉及相关信号通路研究现状进行阐述。

关键词: 支气管肺发育不良, 肺动脉高压, 诊断, 治疗, 信号传导, 信号通路, 婴儿，早产

Bronchopulmonary dysplasia (BPD) is the most common complication of premature infants. About 25% children with moderate to severe BPD may be complicated with BPD-associated pulmonary hypertension (PH), which is the main reason that affects survival rate and life quality of children with BPD in the future. At present, prevention and treatments for BPD and BPD-associated PH are so limited that it is urgent to investigate its pathogenesis and subsequently targeted treatment. In recent years, many studies have found abnormalities in many signaling pathways during the development of BPD and BPD-associated PH, such as angiopoietin (Ang), vascular endothelial growth factor (VEGF), transforming growth factor (TGF)-β, Wnt, connective tissue growth factor (CTGF), fibroblast growth factor (FGF)10, microRNA (miRNA), and caveolin (Cav)-1-related signaling pathways. All these findings could deepen the understanding of pathogenesis of BPD and BPD-associated PH and provide new ideas of the treatment. This paper reviews the current researches of signaling pathways involved in BPD and BPD-associated PH.

Key words: Bronchopulmonary dysplasia, Hypertension, pulmonary, Diagnose, Therapy, Signal transduction, Signaling pathways, Infant, premature
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