探讨2种子宫内膜准备方案对于接受冻融胚胎移植(FET)受试者的临床妊娠结局影响。

选择2010年6月至2015年6月，在苏北人民医院生殖医学中心施行FET的947个周期为研究对象，将其中采用自然周期子宫内膜准备方案的501个FET周期，纳入自然周期组，采用人工周期子宫内膜准备方案的446个FET周期，纳入人工周期组。回顾性分析2组受试者临床病历资料，统计学比较2组FET周期一般临床资料、临床妊娠结局及不同年龄受试者的临床妊娠率差异。

①2组FET周期的受试者一般临床资料，包括年龄、不孕年限、移植日子宫内膜厚度、基础雌激素及孕激素浓度、基础卵泡刺激素(FSH)及促黄体激素(LH)水平，以及移植胚胎数分别比较，差异均无统计学意义(P>0.05)。②2组FET周期临床妊娠结局，包括胚胎着床率、临床妊娠率、异位妊娠率、自然流产率及活产率分别比较，差异亦均无统计学意义(P>0.05)。③2组FET周期年龄≤30岁及>30～35岁受试者的临床妊娠率分别比较，差异均无统计学意义(P>0.05)；但自然周期组年龄>35～40岁受试者的临床妊娠率，较人工周期组高，并且差异有统计学意义(χ²＝5.011，P＝0.025)。

自然周期和人工周期2种子宫内膜准备方案，对FET妊娠结局无明显影响。对于年龄>35～40岁女性施行FET，选择自然周期子宫内膜准备方案，可能优于人工周期。

To compare the clinical pregnancy outcomes of two kinds of endometrial preparation protocols in frozen-thawed embryos transfer (FET).

Chose 947 FET cycle as the research subjects in Reproductive Medicine Center of Northern Jiangsu People′s Hospital from June 2010 to June 2015. The 501 FET cycles which took endometrial preparation protocol of natural cycles were included in the natural cycle group, and the 446 FET cycles which took endometrial preparation protocol of artificial cycle were included in the artificial cycle group. The clinical medical records of two groups were retrospectively analyzed. The general clinical data, clinical pregnancy outcomes and differences of clinical pregnancy rates of different age subjects between subjects of two groups of FET cycles were compared statistically.

①There were no significant differences between two groups of FET cycles in general clinical data, including age, duration of infertility, endometrial thickness on transplantation day, basal estrogen and progesterone concentrations, basal follicle stimulating hormone (FSH) and luteinizing hormone (LH) levels, and the number of transplantation embryos (P>0.05). ②There were no significant differences between two groups of FET cycles in clinical pregnancy outcomes, including embryo implantation rate, clinical pregnancy rate, ectopic pregnancy rate, miscarriage rate and live birth rate (P>0.05); ③There were no significant differences between two groups of FET cycles in the clinical pregnancy rates in age of ≤30 and >30-35 years old women, however, the clinical pregnancy rate in age of >35-40 years old women of natural cycle group was higher than that of artificial cycle group, and the difference was statistically significant (χ²=5.011, P=0.025).

Natural cycle and artificial cycle of endometrial preparation protocols have no obvious different effects on pregnancy outcomes of FET. But for age >35-40 years old women, natural cycle may be superior to artificial cycle for FET.