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中华妇幼临床医学杂志(电子版) ›› 2017, Vol. 13 ›› Issue (01) : 84 -87. doi: 10.3877/cma.j.issn.1673-5250.2017.01.015

所属专题: 文献

论著

体外受精-胚胎移植术后卧床休息时间对妊娠结局的影响
蔡美燕1, 孙小玲1,()   
  1. 1. 210008 南京大学医学院附属鼓楼医院生殖医学中心
  • 收稿日期:2016-08-11 修回日期:2016-11-12 出版日期:2017-02-01
  • 通信作者: 孙小玲

Influences of bed rest time after in vitro fertilization-embryo transfer on pregnancy outcomes

Meiyan Cai1, Xiaoling Sun1,()   

  1. 1. Center of Reproductive Medicine, Nanjing Drum Tower Hospital, Affiliated Hospital of Nanjing University Medical School, Nanjing 210008, Jiangsu Province, China
  • Received:2016-08-11 Revised:2016-11-12 Published:2017-02-01
  • Corresponding author: Xiaoling Sun
  • About author:
    Corresponding author: Sun Xiaoling, Email:
引用本文:

蔡美燕, 孙小玲. 体外受精-胚胎移植术后卧床休息时间对妊娠结局的影响[J]. 中华妇幼临床医学杂志(电子版), 2017, 13(01): 84-87.

Meiyan Cai, Xiaoling Sun. Influences of bed rest time after in vitro fertilization-embryo transfer on pregnancy outcomes[J]. Chinese Journal of Obstetrics & Gynecology and Pediatrics(Electronic Edition), 2017, 13(01): 84-87.

目的

探讨体外受精-胚胎移植(IVF-ET)术后不同卧床休息时间对妊娠结局的影响。

方法

选择2010年6月至2014年6月于南京大学医学院附属鼓楼医院生殖医学中心因不孕接受IVF-ET治疗的2 262例不孕患者,共计2 262个周期为研究对象。根据患者胚胎移植后不同卧床休息时间,将其分为A组(755个周期,胚胎移植后卧床休息10 min后离院),B组(526个周期,胚胎移植后卧床休息30 min后离院),C组(506个周期,胚胎移植后卧床休息1 h后离院),D组(475个周期,胚胎移植后卧床休息2 h后离院)。统计学比较4组患者的受精率、胚胎种植率及临床妊娠率。本研究患者接受IVF-ET治疗前均签署知情同意书,并经过南京大学医学院附属鼓楼医院伦理委员会批准认可。

结果

①4组患者的年龄、不孕年限、获卵数等基本临床资料分别比较,差异均无统计学意义(P>0.05)。②A、B、C、D组患者的受精率分别为87.4%(6 377/7 293)、87.8%(4 792/5 455)、86.9%(4 306/4 954)及87.1%(4 036/4 636);胚胎种植率分别为49.3%(715/1 450)、49.2%(497/1 010)、48.9%(480/982)及48.4%(448/926);临床妊娠率分别为70.6%(533/755)、69.0%(363/526)、70.4%(356/506)及68.0%(323/475)。4组患者的受精率、胚胎种植率、临床妊娠率分别比较,差异均无统计学意义(χ2=2.455,P=0.483;χ2=0.221,P=0.974;χ2=1.151,P=0.765)。

结论

胚胎移植后,患者立即活动或短时间卧床休息,并不影响患者IVF-ET术后妊娠结局。根据患者胚胎移植后的身体和心理状态等因素,对是否需要卧床休息及卧床休息时间进行个体化安排,更为科学、合理。

Objective

To explore the influences of different bed rest time after in vitro fertilization-embryo transfer (IVF-ET) on pregnancy outcomes.

Methods

From June 2010 to June 2014, a total of 2 262 cycles of 2 262 infertility patients in Center of Reproductive Medicine, Nanjing Drum Tower Hospital, Affiliated Hospital of Nanjing University Medical School were selected as research subjects. According to the different bed rest times after embryo transfer, they were divided into 4 groups: group A (755 cycles, left the hospital after 10 minutes of bed rest), group B (526 cycles, left the hospital after 30 minutes of bed rest ), group C (506 cycles, left the hospital after 1 hour of bed rest) and group D (475 cycles, left the hospital after 2 hours of bed rest). Fertility rate, embryo implantation rate, clinical pregnancy rate among 4 groups were compared by statistical methods. Before IVF-ET, all the patients signed the informed consents, and this study was in line with the ethics standards promulgated by the human subjects committee of Nanjing Drum Tower Hospital, Affiliated Hospital of Nanjing University Medical School.

Results

①There were no statistically significant differences among 4 groups in the age, infertility duration, the number of retrieved oocytes and soon (P>0.05). ②The fertility rates of group A, B, C and D were 87.4% (6 377/7 293), 87.8% (4 792/5 455), 86.9% (4 306/4 954) and 87.1% (4 036/4 636), respectively. The embryo implantation rates were 49.3% (715/1 450), 49.2% (497/1 010), 48.9% (480/982) and 48.4% (448/926), respectively. The clinical pregnancy rates were 70.6% (533/755), 69.0% (363/526), 70.4% (356/506) and 68.0% (323/475), respectively. There were no statistically significant differences among 4 groups in fertility rate, embryo implantation rate and clinical pregnancy rate (χ2=2.455, P=0.483; χ2=0.221, P=0.974; χ2=1.151, P=0.765).

Conclusions

To take early ambulation or to stay in bed for a short time after embryo transfer does not affect the pregnancy outcomes of IVF-ET. It is more scientific and reasonable to arrange the need for bed rest and bed rest time individually according to the physical and psychological status of the patients after embryo transfer.

表1 4组不孕患者基本临床资料比较(±s)
表2 4组不孕患者胚胎种植及妊娠结局比较[%(例数/例数′)]
[1]
陈骞,孙海翔,胡娅莉,等. 子宫内膜厚度对体外受精-胚胎移植治疗结局的影响[J]. 生殖与避孕,2008, 28(12):730-733.
[2]
张胜坤,曹义娟,张蓓,等. 体外受精-胚胎移植周期临床妊娠影响因素的研究进展[J/CD]. 中华妇幼临床医学杂志(电子版), 2013, 9(4): 546-549.
[3]
Li B, Zhou H, Li W. Bed rest after embryo transfer[J]. Eur J Obstet Gynecol Reprod Biol, 2011, 155(2): 125-128.
[4]
罗淑荣. 宫腔超声造影对宫腔内病变的诊断意义[J]. 中国临床医学影像杂志,2011, 22(10): 733-734.
[5]
孔娜,刘景瑜,陈华,等. 子宫内膜厚度和形态对体外受精/单精子注射-胚胎移植结果的预测[J]. 临床和实验医学杂志,2013, 12(9): 696-698.
[6]
郑威利. 腹部超声与阴道超声在诊断早期妊娠中的应用效果[J]. 实用妇科内分泌电子杂志,2015, 2(5): 164-165.
[7]
Küçük M. Bed rest after embryo transfer: is it harmful?[J]. Eur J Obstet Gynecol Reprod Biol, 2013, 167(2): 123-126.
[8]
Waterstone J, Parsons J, Bolton V. Recumbent rest after embryo transfer[J]. Lancet, 1988, 332(8623): 1318-1319.
[9]
Lambers MJ, Lambalk CB, Schats R, et al. Ultrasonographic evidence that bed rest after embryo transfer is useless[J]. Gynecol Obstet Invest, 2009, 68(2): 122-126.
[10]
Bar-Hava I, Kerner R, Yoeli R, et al. Immediate ambulation after embryo transfer: a prospective study[J]. Fertil Steril, 2005, 83(3): 594-597.
[11]
Klonoff-Cohen H, Chu E, Natarajan L, et al. A prospective study of stress among women undergoing in vitro fertilization or gamete intrafallopian transfer[J]. Fertil Steril, 2001, 76(4): 675-687.
[12]
Purcell KJ, Schembri M, Telles TL, et al. Bed rest after embryo transfer: a randomized controlled trial[J]. Fertil Steril, 2007, 87(6): 1322-1326.
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