探讨体外受精-胚胎移植(IVF-ET)术后不同卧床休息时间对妊娠结局的影响。

选择2010年6月至2014年6月于南京大学医学院附属鼓楼医院生殖医学中心因不孕接受IVF-ET治疗的2 262例不孕患者，共计2 262个周期为研究对象。根据患者胚胎移植后不同卧床休息时间，将其分为A组(755个周期，胚胎移植后卧床休息10 min后离院)，B组(526个周期，胚胎移植后卧床休息30 min后离院)，C组(506个周期，胚胎移植后卧床休息1 h后离院)，D组(475个周期，胚胎移植后卧床休息2 h后离院)。统计学比较4组患者的受精率、胚胎种植率及临床妊娠率。本研究患者接受IVF-ET治疗前均签署知情同意书，并经过南京大学医学院附属鼓楼医院伦理委员会批准认可。

①4组患者的年龄、不孕年限、获卵数等基本临床资料分别比较，差异均无统计学意义(P>0.05)。②A、B、C、D组患者的受精率分别为87.4%(6 377/7 293)、87.8%(4 792/5 455)、86.9%(4 306/4 954)及87.1%(4 036/4 636)；胚胎种植率分别为49.3%(715/1 450)、49.2%(497/1 010)、48.9%(480/982)及48.4%(448/926)；临床妊娠率分别为70.6%(533/755)、69.0%(363/526)、70.4%(356/506)及68.0%(323/475)。4组患者的受精率、胚胎种植率、临床妊娠率分别比较，差异均无统计学意义(χ²＝2.455，P＝0.483；χ²＝0.221，P＝0.974；χ²＝1.151，P＝0.765)。

胚胎移植后，患者立即活动或短时间卧床休息，并不影响患者IVF-ET术后妊娠结局。根据患者胚胎移植后的身体和心理状态等因素，对是否需要卧床休息及卧床休息时间进行个体化安排，更为科学、合理。

To explore the influences of different bed rest time after in vitro fertilization-embryo transfer (IVF-ET) on pregnancy outcomes.

From June 2010 to June 2014, a total of 2 262 cycles of 2 262 infertility patients in Center of Reproductive Medicine, Nanjing Drum Tower Hospital, Affiliated Hospital of Nanjing University Medical School were selected as research subjects. According to the different bed rest times after embryo transfer, they were divided into 4 groups: group A (755 cycles, left the hospital after 10 minutes of bed rest), group B (526 cycles, left the hospital after 30 minutes of bed rest ), group C (506 cycles, left the hospital after 1 hour of bed rest) and group D (475 cycles, left the hospital after 2 hours of bed rest). Fertility rate, embryo implantation rate, clinical pregnancy rate among 4 groups were compared by statistical methods. Before IVF-ET, all the patients signed the informed consents, and this study was in line with the ethics standards promulgated by the human subjects committee of Nanjing Drum Tower Hospital, Affiliated Hospital of Nanjing University Medical School.

①There were no statistically significant differences among 4 groups in the age, infertility duration, the number of retrieved oocytes and soon (P>0.05). ②The fertility rates of group A, B, C and D were 87.4% (6 377/7 293), 87.8% (4 792/5 455), 86.9% (4 306/4 954) and 87.1% (4 036/4 636), respectively. The embryo implantation rates were 49.3% (715/1 450), 49.2% (497/1 010), 48.9% (480/982) and 48.4% (448/926), respectively. The clinical pregnancy rates were 70.6% (533/755), 69.0% (363/526), 70.4% (356/506) and 68.0% (323/475), respectively. There were no statistically significant differences among 4 groups in fertility rate, embryo implantation rate and clinical pregnancy rate (χ²=2.455, P=0.483; χ²=0.221, P=0.974; χ²=1.151, P=0.765).

To take early ambulation or to stay in bed for a short time after embryo transfer does not affect the pregnancy outcomes of IVF-ET. It is more scientific and reasonable to arrange the need for bed rest and bed rest time individually according to the physical and psychological status of the patients after embryo transfer.