切换至 "中华医学电子期刊资源库"

中华妇幼临床医学杂志(电子版) ›› 2016, Vol. 12 ›› Issue (06) : 690 -693. doi: 10.3877/cma.j.issn.1673-5250.2016.06.013

所属专题: 文献

论著

低剂量米索前列醇联合复方米非司酮对中孕期引产的临床效果研究
冯鑫1,(), 徐进芳1, 徐杰1, 石中华2   
  1. 1. 222000江苏连云港市东方医院妇产科
    2. 210004南京医科大学附属南京市妇幼保健院产科
  • 收稿日期:2016-05-22 修回日期:2016-09-24 出版日期:2016-12-01
  • 通信作者: 冯鑫

Research of clinical effects of low dose of misoprostol combined with compound mifepristone tablets in treatment of induced labor in second pregnancy trimester

Xin Feng1,(), Jinfang Xu1, Jie Xu1, Zhonghua Shi2   

  1. 1. Department of Obstetrics and Gynecology, Oriental Hospital of Lianyungang, Lianyugang 222000, Jiangsu Province, China
    2. Department of Obstetrics and Gynecology, Hospital Affiliated to Nanjing Medical University, Nanjing 210004, Jiangsu Province, China
  • Received:2016-05-22 Revised:2016-09-24 Published:2016-12-01
  • Corresponding author: Xin Feng
  • About author:
    Corresponding author: Feng Xin, Email:
引用本文:

冯鑫, 徐进芳, 徐杰, 石中华. 低剂量米索前列醇联合复方米非司酮对中孕期引产的临床效果研究[J]. 中华妇幼临床医学杂志(电子版), 2016, 12(06): 690-693.

Xin Feng, Jinfang Xu, Jie Xu, Zhonghua Shi. Research of clinical effects of low dose of misoprostol combined with compound mifepristone tablets in treatment of induced labor in second pregnancy trimester[J]. Chinese Journal of Obstetrics & Gynecology and Pediatrics(Electronic Edition), 2016, 12(06): 690-693.

目的

探讨低剂量米索前列醇联合复方米非司酮方案应用于中孕期引产的临床效果及安全性。

方法

选取2012年1月1日至2015年12月31日,连云港市东方医院收治的80例中孕期引产孕妇为研究对象。根据随机数字表法,将其随机分为观察组(n=40)与对照组(n=40)。观察组孕妇接受低剂量米索前列醇联合复方米非司酮方案引产,对照组孕妇接受依沙吖啶联合复方米非司酮方案引产。统计学比较2组孕妇采取不同引产方案的完全引产率、不完全引产率、引产成功率、总引产时间、阴道出血量及不良反应率等。2组孕妇年龄、孕龄、产次等一般临床资料比较,差异均无统计学意义(P>0.05)。引产前,与所有孕妇签署知情同意书。

结果

①观察组孕妇完全引产率高于对照组,并且差异有统计学意义(χ2=4.013,P=0.045)。2组孕妇不完全引产率及引产成功率比较,差异均无统计学意义(P>0.05)。②观察组孕妇总引产时间较对照组显著缩短,阴道出血量较对照组显著降低,并且差异均有统计学意义(t=6.732、5.118,P=0.001、0.013)。③2组孕妇胃肠道反应、高热反应及肝功能损害发生率分别比较,差异均无统计学意义(P>0.05)。

结论

低剂量米索前列醇联合复方米非司酮引产方案应用于中孕期引产,效果较好,并不增加不良反应率,安全性高。因本研究纳入样本量相对较小,其引产效果及安全性,仍需多中心、大样本、随机对照试验研究进一步证实。

Objective

To explore the clinical effects and safety of low dose of misoprostol combined with compound mifepristone tablets in treatment of induced labor in second pregnancy trimester.

Methods

From January 1, 2012 to December 31, 2015, a total of 80 cases of pregnant women who received induced labor in second pregnancy trimester in Oriental Hospital of Lianyungang were selected as research subjects. According to the random number table method, they were randomly divided into observation group (n=40) and control group (n=40). The pregnant women in observation group were given low dose of misoprostol combined with compound mifepristone tablets, while pregnant women in control group were treated with ethacridine combined with compound mifepristone tablets. The complete abortion rate, incomplete abortion rate, successful rate of induced labor, total induced labor time, vaginal hemorrhage volume and incidence of adverse reactions of two groups were statistically compared. There were no significant differences between two groups in maternal age, gestational age and parity (P>0.05). All pregnant women signed the informed consents before abortion.

Results

①Compared with control group, the complete abortion rate in observation group was significantly increased and the difference was statistically significant (χ2=4.013, P=0.045). But there were no significant differences between two groups in incomplete abortion rate and successful rate of induced labor (P>0.05). ②Compared with control group, the total induced labor time in observation group was significantly shortened, the vaginal hemorrhage volume was significantly decreased, and both the differences were statistically significant (t=6.732, P=0.001; t=5.118, P=0.013). ③There were no significant differences between two groups in the rates of gastrointestinal reaction, hyperpyrexia reaction rate and liver function injury (P>0.05).

Conclusions

The clinical effect of low dose of misoprostol combined with compound mifepristone tablets in treatment of induced labor in second pregnancy trimester is good and safe without increasing the incidence of adverse reaction. As the sample size in this study is relatively small, induction effect and safety of low dose of misoprostol combined with compound mifepristone tablets, still need a large sample, multicenter, randomized controlled trials to further confirm.

表1 2组孕妇采取不同引产方案的完全引产率、不完全引产率、引产成功率比较[例数(%)]
表2 2组孕妇采取不同引产方案的引产情况比较(±s)
表3 2组孕妇采取不同引产方案的不良反应发生情况比较[例数(%)]
[1]
游玉卿. 米非司酮配伍不同剂量米索前列醇药物流产临床效果观察[J]. 中国现代医生,2013, 48(36): 184-185.
[2]
Sundaram S, Diaz JP, González-Quintero VH. Rectal misoprostol vs 15-methyl prostaglandin F2alpha for retained placenta after second-trimester delivery[J]. Am J Obswt Gyneeol, 2013, 200(5): e24-e26.
[3]
房红英,郑翠萍. 米非司酮配伍米索前列醇用于中期妊娠引产成功研究[J]. 中国医师进修杂志:综合版,2014, 29(10): 63-64.
[4]
Bhattacharyya SK, Mukherji J, Kamilya GS. Two regimens of vaginal misoprostol in second trimester termination of pregnancy: a prospective randomised trial[J]. Acta Obstet Gynecol Scand, 2006, 85(12): 1458-62.
[5]
谢幸,苟文丽. 妇产科学[M]. 北京:人民卫生出版社,2013: 47-48.
[6]
邱怡. 地诺前列酮用于合并妊娠期高血压孕妇引产的临床观察[J]. 医学临床研究,2015, 32(5): 1006-1008.
[7]
单丹,胡雅毅. 瘢痕子宫妊娠引产及促宫颈成熟的研究进展[J/CD]. 中华妇幼临床医学杂志:电子版,2016, 12(2): 228-231.
[8]
蔡昱,何川,战媛,等. 利凡诺、米非司酮联合米索前列醇中期引产的临床效果[J]. 广西医学,2015, 37(9): 1328-1330.
[9]
冯建玲,张建玲,张静茹,等. 大剂量米非司酮联合米索前列醇用于中期妊娠引产的临床效果观察[J]. 临床合理用药杂志,2015, 8(6A): 80-81.
[10]
中华医学会计划生育学分会. 米非司酮配伍米索前列醇终止8~16周妊娠的应用指南[J]. 中华妇产科杂志,2015, 50(5): 321-322.
[11]
王学勤,蔡俊. 瘢痕子宫中晚期妊娠引产50例治疗体会[J]. 医学临床研究,2012, 29(6): 1175-1176.
[12]
张蓓. 米非司酮配合依沙吖啶在疤痕子宫中期引产中的应用[J]. 中国初级卫生保健,2012, 26(3): 73-74.
[13]
韩玉斌. 米非司酮配伍利凡诺溶液用于瘢痕子宫中期妊娠引产临床分析[J/CD]. 中华妇幼临床医学杂志:电子版,2009, 5(6): 590-593.
[1] 陈谊, 文华轩, 陈琮瑛, 姚远, 李胜利. 胎儿半侧巨脑畸形的产前超声诊断及研究分析[J]. 中华医学超声杂志(电子版), 2023, 20(01): 28-34.
[2] 马雪松, 吴青青, 王莉, 杨丽曼, 高凤云, 李晓菲, 玄英华, 李巧. 超声在诊断孕中期完全性子宫破裂中的价值[J]. 中华医学超声杂志(电子版), 2020, 17(06): 509-513.
[3] 陈金卫, 戴常平, 申屠伟慧, 张伟娟, 张蕊, 王红英. 胎儿超声筛查不同胎龄胎儿先天性唇腭裂的检查时间及检出率比较[J]. 中华妇幼临床医学杂志(电子版), 2022, 18(04): 442-448.
[4] 周燕, 金靓, 王志群, 卢先艳, 戴毅敏. 对促宫颈成熟与引产孕产妇的全程分娩管理模式[J]. 中华妇幼临床医学杂志(电子版), 2022, 18(03): 350-356.
[5] 王巍, 李顺双, 刘刚. 《2020 ACOG实践简报:孕龄≤70 d药物流产(No.225)》解读[J]. 中华妇幼临床医学杂志(电子版), 2022, 18(03): 275-281.
[6] 谢良玉, 王和, 赵小文, 张迅, 张雪梅, 刘洪倩, 祝茜, 王婧, 胡婷, 张竹, 赖怡, 秦利, 刘珊玲. 中孕期胎儿染色体异常高危孕妇羊水细胞胎儿染色体核型及介入性产前诊断指征的大样本分析[J]. 中华妇幼临床医学杂志(电子版), 2022, 18(01): 73-79.
[7] 姚利民, 章锦曼, 朱姝, 黎冬梅, 余蕊, 陆丽花, 赵庆芬, 丁云川. 18-三体综合征胎儿中孕期超声检查与染色体核型结果分析[J]. 中华妇幼临床医学杂志(电子版), 2021, 17(05): 590-597.
[8] 曹佳晨, 孔祥, 葛凡, 鞠捷, 徐金金, 陆杨, 冯翀. 一次性球囊宫颈扩张器在单纯性临界羊水过少与单纯性羊水过少足月妊娠产妇引产中的临床应用[J]. 中华妇幼临床医学杂志(电子版), 2021, 17(03): 339-346.
[9] 张彦春, 刘凯波, 张雯, 徐宏燕. 中孕期血清学筛查联合无创产前检测在唐氏综合征产前筛查与诊断中的应用[J]. 中华妇幼临床医学杂志(电子版), 2020, 16(06): 709-713.
[10] 徐婷婷, 周芷伊, 刘娜, 邓春燕, 黄桂琼, 王晓东, 余海燕. 中孕期使用子宫颈托对双胎妊娠孕妇早产预防的系统评价[J]. 中华妇幼临床医学杂志(电子版), 2019, 15(03): 253-261.
[11] 魏璐, 罗剑儒, 杨霄, 邓洪, 刘颖, 刘兴会. 胎盘前置状态孕妇中孕期引产的研究进展[J]. 中华妇幼临床医学杂志(电子版), 2019, 15(02): 222-227.
[12] 张郁妍, 胡滨, 张伟红, 徐楣, 朱慧, 羊馨玥, 刘海玲. 妊娠中期心血管超声参数与肝功能的相关性及对不良妊娠结局的预测价值[J]. 中华消化病与影像杂志(电子版), 2023, 13(06): 499-504.
[13] 刘养奇, 林伟研, 欧伟麟, 林志丰, 柯莉, 林琳, 陈艳红. 依沙吖啶及其联合方案在中期妊娠引产中的应用[J]. 中华产科急救电子杂志, 2021, 10(04): 242-246.
[14] 王谢桐. 辅助生殖后中孕期多胎妊娠减胎相关问题[J]. 中华产科急救电子杂志, 2019, 08(03): 137-140.
[15] 陈晓璐, 陈艳红, 苏春宏, 陈敦金. 悬吊式胎儿牵引术在特殊病例引产中的应用[J]. 中华产科急救电子杂志, 2019, 08(02): 121-124.
阅读次数
全文


摘要