探讨低剂量米索前列醇联合复方米非司酮方案应用于中孕期引产的临床效果及安全性。

选取2012年1月1日至2015年12月31日，连云港市东方医院收治的80例中孕期引产孕妇为研究对象。根据随机数字表法，将其随机分为观察组(n＝40)与对照组(n＝40)。观察组孕妇接受低剂量米索前列醇联合复方米非司酮方案引产，对照组孕妇接受依沙吖啶联合复方米非司酮方案引产。统计学比较2组孕妇采取不同引产方案的完全引产率、不完全引产率、引产成功率、总引产时间、阴道出血量及不良反应率等。2组孕妇年龄、孕龄、产次等一般临床资料比较，差异均无统计学意义(P>0.05)。引产前，与所有孕妇签署知情同意书。

①观察组孕妇完全引产率高于对照组，并且差异有统计学意义(χ²＝4.013，P＝0.045)。2组孕妇不完全引产率及引产成功率比较，差异均无统计学意义(P>0.05)。②观察组孕妇总引产时间较对照组显著缩短，阴道出血量较对照组显著降低，并且差异均有统计学意义(t＝6.732、5.118，P＝0.001、0.013)。③2组孕妇胃肠道反应、高热反应及肝功能损害发生率分别比较，差异均无统计学意义(P>0.05)。

低剂量米索前列醇联合复方米非司酮引产方案应用于中孕期引产，效果较好，并不增加不良反应率，安全性高。因本研究纳入样本量相对较小，其引产效果及安全性，仍需多中心、大样本、随机对照试验研究进一步证实。

To explore the clinical effects and safety of low dose of misoprostol combined with compound mifepristone tablets in treatment of induced labor in second pregnancy trimester.

From January 1, 2012 to December 31, 2015, a total of 80 cases of pregnant women who received induced labor in second pregnancy trimester in Oriental Hospital of Lianyungang were selected as research subjects. According to the random number table method, they were randomly divided into observation group (n=40) and control group (n=40). The pregnant women in observation group were given low dose of misoprostol combined with compound mifepristone tablets, while pregnant women in control group were treated with ethacridine combined with compound mifepristone tablets. The complete abortion rate, incomplete abortion rate, successful rate of induced labor, total induced labor time, vaginal hemorrhage volume and incidence of adverse reactions of two groups were statistically compared. There were no significant differences between two groups in maternal age, gestational age and parity (P>0.05). All pregnant women signed the informed consents before abortion.

①Compared with control group, the complete abortion rate in observation group was significantly increased and the difference was statistically significant (χ²=4.013, P=0.045). But there were no significant differences between two groups in incomplete abortion rate and successful rate of induced labor (P>0.05). ②Compared with control group, the total induced labor time in observation group was significantly shortened, the vaginal hemorrhage volume was significantly decreased, and both the differences were statistically significant (t=6.732, P=0.001; t=5.118, P=0.013). ③There were no significant differences between two groups in the rates of gastrointestinal reaction, hyperpyrexia reaction rate and liver function injury (P>0.05).

The clinical effect of low dose of misoprostol combined with compound mifepristone tablets in treatment of induced labor in second pregnancy trimester is good and safe without increasing the incidence of adverse reaction. As the sample size in this study is relatively small, induction effect and safety of low dose of misoprostol combined with compound mifepristone tablets, still need a large sample, multicenter, randomized controlled trials to further confirm.