切换至 "中华医学电子期刊资源库"

中华妇幼临床医学杂志(电子版) ›› 2016, Vol. 12 ›› Issue (04) : 489 -492. doi: 10.3877/cma.j.issn.1673-5250.2016.04.023

所属专题: 文献

综述

多肽类激素kisspeptin的生殖内分泌功能研究进展
袁媛1   
  1. 1. 030001 太原,山西医科大学第一医院计划生育研究室
  • 收稿日期:2016-01-11 修回日期:2016-05-11 出版日期:2016-08-01

Research progress of kisspeptin in reproductive endocrine function

Yuan Yuan1   

  1. 1. Laboratory of Family Planning, First Hospital of Shanxi Medical University, Taiyuan 030001, Shanxi Province, China
  • Received:2016-01-11 Revised:2016-05-11 Published:2016-08-01
  • About author:
    Corresponding author: Zheng Meiling, Email:
引用本文:

袁媛. 多肽类激素kisspeptin的生殖内分泌功能研究进展[J]. 中华妇幼临床医学杂志(电子版), 2016, 12(04): 489-492.

Yuan Yuan. Research progress of kisspeptin in reproductive endocrine function[J]. Chinese Journal of Obstetrics & Gynecology and Pediatrics(Electronic Edition), 2016, 12(04): 489-492.

多肽类激素kisspeptin是由Kiss-l基因编码的一类C末端具有精氨酸和苯丙氨酸的多肽类激素,广泛分布于全身各组织器官。近年研究发现,多肽类激素kisspeptin在生殖内分泌系统发挥着重要作用,通过调控性腺轴,参与个体性分化、性发育、性成熟、月经周期及妊娠过程。同时,多肽类激素kisspeptin被证实与特发性性腺功能减退症(IHH)、女童特发性性早熟、卵巢早衰(POF)、多囊卵巢综合征(PCOS)、自然流产及滋养细胞肿瘤等疾病的发生具有一定相关性。

Kisspeptin, a type of polypeptide hormone, is a kind of peptide encoded by Kiss-1 gene and widely distributed throughout the tissues and organs. In recent years, studies have shown that kisspeptin is a key factor in the endocrinological regulation of reproduction. It can promote the onset of puberty and participate in the sexual maturity, menstrual cycle, pregnancy by regulating the gonad axis. At the same time, it is confirmed that kisspeptin have certain correlations with idiopathic hypogona-dotropic hypogonadism (IHH), idiopathic precocious puberty of the girls, premature ovarian failure (POF), polycystic ovary (PCOS), spontaneous abortion and placental site trophoblastic tumor disease.

[1]
Lee JH, Miele ME, Hicks DJ, et al. KiSS-1, a novel human malignant melanoma metastasis-suppressor gene[J]. J Natl Cancer Inst, 1996, 88(23): 1731-1737.
[2]
Jayasena CN, Abbara A, Izzi-Engbeaya C, et al. Reduced levels of plasma kisspeptin during the antenatal booking visit are associated with increased risk of miscarriage[J]. J Clin Endocrinol Metab, 2014, 99(12): E2652-E2660.
[3]
Ohtaki T, Shintani Y, Honda S, et al. Metastasis suppressor gene KiSS-1 encodes peptide ligand of a G-protein-coupled receptor[J]. Nature, 2001, 411(6837): 613-617.
[4]
Muir AI, Chamberlain L, Elshourbagy NA, et al. AXOR12, a novel human G protein-coupled receptor, activated by the peptide KiSS-1[J]. J Biol Chem, 2001, 276(31): 28969-28975.
[5]
de Roux N, Genin E, Carel JC, et al. Hypogonadotropic hypogonadism due to loss of function of the KiSS1-derived peptide receptor GPR54[J]. Proc Natl Acad Sci USA, 2003, 100(19): 10972-10976.
[6]
Robertson JL, Clifton DK, de la Iglesia HO, et al. Circadian regulation of Kissl neurons: implications for timing the preovulatory gonadotropin-releasing hormone/luteinizing hormone surge[J]. Endocrinology, 2009, 150(8): 3664-3671.
[7]
Xu P, Wang Y, Piao Y, et al. Effects of matrix proteins on the expression of matrix metalloproteinase-2, -9, and -14 and tissue inhibitors of metalloproteinases in human cytotrophoblast cells during the first trimester[J]. Biol Reprod, 2001, 65(1): 240-246.
[8]
Khankin EV, Royle C, Karumanchi SA. Placental vasculature in health and disease[J]. Semin Thromb Hemost, 2010, 36(3): 309-320.
[9]
Richard N, Corvaisier S. KiSS-1 and GPR54 at the pituitary level: overview and recent insights[J]. Peptides, 2009, 30(1): 123-129.
[10]
彭婧,钟婷,张鹏, 等. Kisspeptin-10对大鼠卵巢黄体细胞内分泌功能的影响及其机理[J]. 中国药理通讯,2013, 30(4): 29-30.
[11]
Wu S, Zhang H, Tian J, et al. Expression of kisspeptin/GPR54 and PIBF/PR in the first trimester trophoblast and decidua of women with recurrent spontaneous abortion[J]. Pathol Res Prac, 2014, 210(1): 47-54.
[12]
Millar RP, Roseweir AK, Tello JA, et al. Kisspeptin antagonists: unraveling the role of kisspeptin in reproductive physiology[J]. Brain Res, 2010, 1364(1): 81-89.
[13]
翟君钰. Kisspeptin与卵巢功能及排卵的关联性研究[D]. 济南:山东大学,2014.
[14]
Peng J, Tang M, Zhang BP, et al. Kisspeptin stimulates progesterone secretion via the Erkl/2 mitogen-activated protein kinase signaling pathway in rat luteal cells[J]. Fertil Steril, 2013, 99(5): 1436-1443.
[15]
Qiao C, Wang C, Zhao J, et al. Correction: elevated expression of KiSS-1 in placenta of Chinese women with early-onset preeclampsia[J]. PLoS One, 2013, 8(12): e48937.
[16]
Witchel SF, Tena-Sempere M. The Kiss1 system and polycystic ovary syndrome: lessons from physiology and putative pathophysiologic implications[J]. Fertil Steril, 2013, 100(1): 12-22.
[17]
王军,娄玉杰. 能量平衡与哺乳动物生殖:瘦素和KiSS-1/GPR54系统的最新研究进展[J]. 动物营养学报,2011, 23(1): 1-4.
[18]
吴邵花. Kisspeptin/GPR54表达异常与不明原因复发性流产发病关系的研究[D]. 苏州:苏州大学,2013.
[19]
孙晨,钟刚. Kiss-1基因与胚胎种植和发育的关系[J]. 中国妇幼保健,2007, 22(9): 1210-1212.
[20]
Krieg SA, Fan X, Hong Y, et al. Global alteration in gene expression profiles of deciduas from women with idiopathic recurrent pregnancy loss[J]. Mol Hu Reprod, 2012, 18(9): 442-450.
[21]
田冀雯. KiSS-1基因对妊娠滋养细胞生物学行为影响及其在复发性流产中作用机制的研究[D]. 苏州:苏州大学,2014.
[22]
Millar RP, Roseweir AK, Tello JA, et al. Kisspeptin antagonists: unraveling the role of kisspeptin in reproductive physiology[J]. Brain Res, 2010, 1364: 81-89.
[23]
Cartwright JE, Williams PJ. Altered placental expression of kisspeptin and its receptor in pre-eclampsia[J]. J Endocrinol, 2012, 214(1): 79-85.
[24]
Smets EML, Deurloo KL, Go ATJI, et al. Decreased plasma levels of metastin in early pregnancy are associated with small for gestational age neonates[J]. Prenat Diagn, 2008, 28(4): 299-303.
[25]
Clarke H, Dhillo WS, Jayasena CN. Comprehensive review on kisspeptin and its role in reproductive disorders[J]. Endocrinol Metab, 2015, 30(2): 124-141.
[1] 邹佳桐, 王颂扬, 徐薇, 余婷婷, 叶红霞, 谯小勇. 自然流产女性精神健康问题的相关危险因素分析[J]. 中华妇幼临床医学杂志(电子版), 2023, 19(01): 77-84.
[2] 魏瑗, 罗红. 子宫动脉血流参数及血清学指标分别对早期先兆流产孕妇的预测价值[J]. 中华妇幼临床医学杂志(电子版), 2022, 18(01): 111-119.
[3] 张碧云, 肖小敏, 钟兴明, 苗竹林, 李蕾蕾, 黄丽艳. 肠道菌群紊乱与女性生殖内分泌疾病相关性研究现状[J]. 中华妇幼临床医学杂志(电子版), 2021, 17(04): 488-491.
[4] 陈恒禧, 成姝婷, 肖丽, 黄薇. 基于GEO数据库的不明原因复发性自然流产患者子宫内膜差异基因筛选及其生物信息学分析[J]. 中华妇幼临床医学杂志(电子版), 2020, 16(05): 551-557.
[5] 戴祎, 生诚成, 王珺. 早、中孕期宫颈息肉摘除术孕妇妊娠结局及其影响因素分析[J]. 中华妇幼临床医学杂志(电子版), 2019, 15(06): 669-675.
[6] 王淼, 宋小宇, 高宇, 李学超. 不同剂量重组人生长激素治疗儿童中枢性性早熟的临床效果[J]. 中华妇幼临床医学杂志(电子版), 2019, 15(04): 437-443.
[7] 王淼, 宋小宇, 高宇, 李学超. 性早熟女性患儿及其母亲的心理功能评估[J]. 中华妇幼临床医学杂志(电子版), 2019, 15(02): 192-197.
[8] 魏丽娜, 张俊博, 赵考考, 孙秀芹. 不同治疗方案在体外受精-胚胎移植患者中的临床疗效比较[J]. 中华妇幼临床医学杂志(电子版), 2018, 14(03): 317-323.
[9] 程苾恒, 陈建华, 徐万洲. 单核苷酸多态性微阵列技术检测自然流产妊娠产物的应用价值[J]. 中华妇幼临床医学杂志(电子版), 2018, 14(02): 236-240.
[10] 邓唐, 李尚为. 部分卵母细胞胞浆内单精子注射周期中影响其常规体外受精受精率的相关因素分析[J]. 中华妇幼临床医学杂志(电子版), 2016, 12(05): 530-534.
[11] 解淑钰, 李旗, 司彩云, 陶月红. 促黄体生成素基础值<0.1 IU/L的外周性与中枢性性早熟女童的临床特点比较[J]. 中华临床医师杂志(电子版), 2019, 13(02): 111-115.
[12] 侯悦, 刘福朋, 张艳红, 张梅, 班博, 赵倩倩, 张红丽, 李艳英. 基础黄体生成素水平对女童中枢性性腺启动状态的预测能力分析[J]. 中华诊断学电子杂志, 2023, 11(02): 109-114.
阅读次数
全文


摘要