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中华妇幼临床医学杂志(电子版) ›› 2015, Vol. 11 ›› Issue (06) : 789 -792. doi: 10.3877/cma.j.issn.1673-5250.2015.06.023

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综述

血清microRNA在妇科恶性肿瘤临床诊断及其预后评价中的研究进展
何少仪1, 孙小丽1, 罗喜平1,*,*()   
  1. 1. 510010 广州医科大学附属广东省妇幼保健院妇科
  • 收稿日期:2015-07-09 修回日期:2015-11-25 出版日期:2015-12-01
  • 通信作者: 罗喜平

Research progress of serum microRNA in gynecologic malignant tumor clinical application

Shaoyi He1, Xiaoli Sun1, Xiping Luo1()   

  1. 1. Department of Obstetrics and Gynecology, Guangdong Maternal and Child Health Care Hospital, Guangzhou Medical University, Guangzhou 510010, Guangdong Province, China
  • Received:2015-07-09 Revised:2015-11-25 Published:2015-12-01
  • Corresponding author: Xiping Luo
  • About author:
    Corresponding author: Luo Xiping, Email:
引用本文:

何少仪, 孙小丽, 罗喜平. 血清microRNA在妇科恶性肿瘤临床诊断及其预后评价中的研究进展[J/OL]. 中华妇幼临床医学杂志(电子版), 2015, 11(06): 789-792.

Shaoyi He, Xiaoli Sun, Xiping Luo. Research progress of serum microRNA in gynecologic malignant tumor clinical application[J/OL]. Chinese Journal of Obstetrics & Gynecology and Pediatrics(Electronic Edition), 2015, 11(06): 789-792.

微小RNA(miRNA)是一类在人体内广泛分布的内源性非编码RNA,主要在转录后水平对靶基因的表达起调节作用,并在肿瘤的发生、发展中具有癌基因或抑癌基因功能。血清中miRNA表达水平与组织中表达水平相一致,因此可通过检测血清中miRNA水平来诊断疾病和评估病情。本文主要讨论血清miRNA在妇科恶性肿瘤早期诊断和预后评估中的临床应用,并对其研究进展进行综述。

MicroRNA(miRNA) is a class of endogenous non-coding RNA, which wide distribution in human body and primarily regulates the expression of target gene in the post-transcriptional level, and it has the function of oncogenes or tumor suppressor genes in the development of tumors. Expression level of serum miRNA is consistent with expression level in tissues, so we may diagnose the disease and assess pathogenetic condition by detect miRNA expression level in serum.This paper reviews the research progress of serum miRNA in clinical application for early diagnosis and assess prognosis of gynecological malignancies.

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