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中华妇幼临床医学杂志(电子版) ›› 2013, Vol. 09 ›› Issue (05) : 650 -652. doi: 10.3877/cma.j.issn.1673-5250.2013.05.018

所属专题： 文献；

论著

血清瘦素和胰岛素生长因子Ⅱ与子宫内膜癌的相关性研究
刘婷婷1,*,*(), 张淑香1, 高维萍1   
  1. 1. 223002　江苏徐州，徐州医学院附属淮安医院妇产科
  • 收稿日期:2013-05-18 修回日期:2013-09-09 出版日期:2013-10-01
  • 通信作者: 刘婷婷

Study on Correlation Between Leptin, IGFⅡand Endometrial Cancer

Ting-ting LIU1(), Shu-xiang ZHANG1, Wei-ping GAO1   

  1. 1. Department of Obstetrics and Gynecology, the Affiliated Huai'an Hospital of Xuzhou Medical College, Huai'an 223002, Jiangsu Province, China
  • Received:2013-05-18 Revised:2013-09-09 Published:2013-10-01
  • Corresponding author: Ting-ting LIU
  • About author:
    (Corresponding author: LIU Ting-ting, Email: )
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刘婷婷, 张淑香, 高维萍. 血清瘦素和胰岛素生长因子Ⅱ与子宫内膜癌的相关性研究[J]. 中华妇幼临床医学杂志(电子版), 2013, 09(05): 650-652.

Ting-ting LIU, Shu-xiang ZHANG, Wei-ping GAO. Study on Correlation Between Leptin, IGFⅡand Endometrial Cancer[J]. Chinese Journal of Obstetrics & Gynecology and Pediatrics(Electronic Edition), 2013, 09(05): 650-652.

目的

探讨血清瘦素(Leptin)和胰岛素生长因子Ⅱ(IGFⅡ)在子宫内膜癌中的表达及其表达的差异在子宫内膜癌的发生发展中的意义。

方法

根据FIGO(2009年)病理分期分为5组，分别为：对照组(n＝40)、Ⅰ期组(n＝15)、Ⅱ期组(n＝10)、Ⅲ期组(n＝8)和Ⅳ期组(n＝7)，采用酶联免疫吸附测定法(enzyme linked immunosorbent assay，ELISA)检测血清Leptin和IGFⅡ的表达(本研究遵循的程序符合本院人体试验委员会制定的伦理学标准，得到该委员会的批准，征得受试对象的知情同意，并与之签署临床研究知情同意书)。

结果

与对照组相比较，Ⅰ期组、Ⅱ期组、Ⅲ期组、Ⅳ期组血清Leptin和IGFⅡ的水平明显上升，差异有统计学意义(P<0.05)。

结论

Leptin和IGFⅡ的表达随着子宫内膜癌分期的升高而明显上升。Leptin和IGFⅡ的表达显著上调可能是促进子宫内膜癌发生发展的机制之一；Leptin和IGFⅡ及其参与的各种反应与子宫内膜癌的发生发展有一定的相关性。

关键词: 子宫内膜新生物, 瘦素, 胰岛素生长因子Ⅱ
Objective

To explore the expression of Leptin and insulin-like growth factor Ⅱ (IGFⅡ)in peripheral blood in endometrial cancer patients and the significance of its expression differences in the development of endometrial cancer.

Methods

According to FIGO(2009), the study object were respectively divided into five groups: control group(n=40), stageⅠgroup(n=15), stage Ⅱgroup(n=10), stage Ⅲgroup(n=8)and stage Ⅳ group(n=7). The expression of Leptin and IGFⅡ in peripheral blood of the study object were measured by enzyme-linked immunosorbent assay(ELISA). The study protocol was approved by the Ethical Review Board of Investigation in Human Beings of The Affiliated Huai'an Hospital of Xuzhou Medical College. Informed consent was obtained from each participating patient.

Results

The level of Leptin and IGFⅡ in endometrial cancer patients were increased significantly in stageⅠgroup, stageⅡgroup, stage Ⅲgroup and stage Ⅳgroup compared with control group. The data has significant difference(P<0.05).

Conclusions

The study shows the expression of Leptin and IGFⅡ increased with the rising of endometrial cancer staging. The expression of Leptin and IGFⅡ significantly increase may be one of mechanisms to promote the development of endometrial cancer. Leptin and IGFⅡand their participation in a variety of reaction have certain relevance with the development of endometrial cancer.

Key words: endometrial neoplasma, Leptin, insulin-like growth factorⅡ
表1 Leptin和IGFⅡ在子宫内膜癌组和对照组中的表达(±s)
Table 1 Expression of Leptin and IGF Ⅱ in endometrial cancer groups and control group(±s)
组别 n Leptin(mg/L) IGF Ⅱ(μg/L)
Ⅰ期组 15 10.21±1.43 0.68±0.11
Ⅱ期组 10 13.62±1.35 0.74±0.14
Ⅲ期组 8 16.26±1.60 0.81±0.12
Ⅳ期组 7 21.32±1.47 0.90±0.10
对照组 40 7.86±2.31 0.58±0.13
F ? 731.03 63.38
P ? <0.05 <0.05
图1 Leptin和IGFⅡ与子宫内膜癌严重程度的相关性分析
Figure 1 Analyze Leptin and IGFⅡ correlation with the severity of endometrial cancer
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