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中华妇幼临床医学杂志(电子版)

中华妇幼临床医学杂志(电子版) ›› 2012, Vol. 08 ›› Issue (05) : 623 -625. doi: 10.3877/cma.j.issn.1673-5250.2012.05.020

所属专题： 文献；

论著

子宫内膜异位症患者体重指数与血清瘦素水平的关系
王化丽1,*,*(), 姜盟1   
  1. 1. 116033　辽宁大连，大连市妇产医院
  • 收稿日期:2012-02-13 修回日期:2012-07-20 出版日期:2012-10-01
  • 通信作者: 王化丽

Relationship Between Body Mass Index and Serum Leptin in Patients With Endometriosis

Hua-li WANG1(), Meng JIANG1   

  1. 1. Dalian Obstetrics and Gynecology Hospital, Dalian 116033, Liaoning Province, China
  • Received:2012-02-13 Revised:2012-07-20 Published:2012-10-01
  • Corresponding author: Hua-li WANG
  • About author:
    (Corresponding author: WANG Hua-lia, Email: )
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王化丽, 姜盟. 子宫内膜异位症患者体重指数与血清瘦素水平的关系[J/OL]. 中华妇幼临床医学杂志(电子版), 2012, 08(05): 623-625.

Hua-li WANG, Meng JIANG. Relationship Between Body Mass Index and Serum Leptin in Patients With Endometriosis[J/OL]. Chinese Journal of Obstetrics & Gynecology and Pediatrics(Electronic Edition), 2012, 08(05): 623-625.

目的

探讨子宫内膜异位症(EMs)患者体重指数(BMI)和血清瘦素水平的关系。

方法

选择2007年1月至2010年12月在本院经术后病理学检查确诊的52例EMs患者的病历资料为研究对象，并按病理学分期分为Ⅰ～Ⅱ期组(n＝26)和Ⅲ～Ⅳ期组(n＝26)。对两组患者临床特征、血清瘦素水平进行比较，并分析BMI与血清瘦素水平的关系(本研究遵循的程序符合本院人体试验委员会所制定的伦理学标准，得到该委员会的批准，分组征得受试对象本人的知情同意，并与之签署临床研究知情同意书)。

结果

两组患者年龄、月经周期、月经期、主要症状、孕产史等临床特征比较，差异无统计学意义(P>0.05)。两组患者BMI和血清瘦素水平比较，差异均有统计学意义(P<0.05)，且两者呈正相关关系(r＝0.03，P<0.05)。Ⅰ～Ⅱ期组腹腔镜手术率显著高于Ⅲ～Ⅳ期组，两组比较，差异有统计学意义(P<0.05)。

结论

BMI与血清瘦素水平在EMs的发生、发展中起重要作用，两者密切相关。

关键词: 子宫内膜异位症, 体重指数, 瘦素
Objective

To investigate the relationship between body mass index (BMI) and serum leptin in patients with endometriosis.

Methods

From January 2007 to December 2010, A total of 52 women with endometriosis were included in the study, and divided into stage Ⅰ-Ⅱ group(n=26) and stage Ⅲ-Ⅳ group(n=26) according to postoperative pathohistological findings. Clinical features, BMI and serum leptin were compared between two groups, and the relationship between BMI and serum leptin was analyzed. The study protocol was approved by the Ethical Review Board of Investigation in Human Being of Dalian Obstetrics and Gynecology Hospital.Informed consent was obtained from each patients.

Results

There was no significant difference in clinical features such as age, menstrual cycle and symptoms between two groups(P>0.05). There had significant differences in both BMI and serum leptin between two groups(P<0.05), and positive correlation was found between BMI and serum leptin(r=0.30, P<0.05). The incidence rate of laparoscopic surgery in stage Ⅰ-Ⅱ group was obviously higher than that in stage Ⅲ-Ⅳ group(P<0.05).

Conclusions

BMI and serum leptin play important roles in the occurrence and development of endometriosis, and they have strong relationship.

Key words: endometriosis, body mass index, leptin
表1 两组患者临床特征比较[n(%)]
Table 1 Comparison of clinical features between two groups [n(%)]
临床特征 Ⅰ～Ⅱ期组 Ⅲ～Ⅳ期组 P
n 26 26 ?
年龄(±s，岁) 31.8±1.4 32.6±1.1 >0.05
月经周期(d) ? ? ?
? <24 5 (9.6) 4 (7.7) >0.05
? 24～35 20(38.5) 21(40.4) ?
? >35 1 (1.9) 1 (1.9) ?
月经期(d) ? ? ?
? <7 24(46.2) 23(44.2) >0.05
? ≥7 2 (3.8) 3 (5.8) ?
孕产史 ? ? ?
? 有 13(25.0) 12(23.1) >0.05
? 无 13(25.0) 14(26.9) ?
体重(kg) 62.0±0.7 53.6±0.7 <0.05
身高(cm) 162.1±0.3 161.7±0.4 >0.05
BMI(kg/m2) 23.5±0.3 20.2±0.3 <0.05
BMI分级 ? ? ?
? <24.0 8(15.4) 21(40.4) <0.05
? ≥24.0 18(34.6) 5 (9.6) ?
就诊症状 ? ? ?
? 疼痛 10(19.2) 11(21.2) >0.05
? 不孕 3 (5.8) 4 (7.7) ?
? 盆腔包块 11(21.2) 9(17.3) ?
? 其他 2 (3.8) 2 (3.8) ?
手术方式 ? ? ?
? 腹腔镜 24(46.2) 18(34.6) <0.05
? 开腹 2 (3.8) 8(15.4) ?
表2 两组患者血清瘦素水平比较及其与BMI关系(±s)
Table 2 Comparison of serum leptin and its correlation with body mass index between two groups (±s)
组别 n BMI(kg/m2) 血清瘦素(ng/mL)
Ⅰ～Ⅱ期组 26 23.2±0.3 33.54±7.32
Ⅲ～Ⅳ期组 26 20.5±0.4 12.67±6.51
P ? <0.05 <0.05
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