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中华妇幼临床医学杂志(电子版) ›› 2013, Vol. 09 ›› Issue (05) : 614 -616. doi: 10.3877/cma.j.issn.1673-5250.2013.05.009

所属专题： 文献；

论著

单纯性单脐动脉对胎儿生长发育的影响
蒋瑜1, 杨太珠1,*,*()   
  1. 1. 610041　成都，四川大学华西第二医院超声科
  • 收稿日期:2013-07-01 修回日期:2013-08-29 出版日期:2013-10-01
  • 通信作者: 杨太珠

Impact on Fetal Growth in Fetal With an Isolated Single Umbilical Artery

Yu JIANG1, Tai-zhu YANG1()   

  1. 1. Department of Ultrasonography, West China Second University Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China
  • Received:2013-07-01 Revised:2013-08-29 Published:2013-10-01
  • Corresponding author: Tai-zhu YANG
  • About author:
    (Corresponding author: YANG Tai-zhu, Email: )
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蒋瑜, 杨太珠. 单纯性单脐动脉对胎儿生长发育的影响[J/OL]. 中华妇幼临床医学杂志(电子版), 2013, 09(05): 614-616.

Yu JIANG, Tai-zhu YANG. Impact on Fetal Growth in Fetal With an Isolated Single Umbilical Artery[J/OL]. Chinese Journal of Obstetrics & Gynecology and Pediatrics(Electronic Edition), 2013, 09(05): 614-616.

目的

探讨单纯性单脐动脉(SUA)对胎儿出生体重及身高的影响。

方法

选取2009年1月至2011年12月在本院分娩，产前诊断为SUA单胎妊娠胎儿中，分娩后证实为单纯性SUA胎儿的临床病历资料为研究对象，并且纳入SUA组(n＝80)。多胎妊娠、胎儿合并其他系统畸形、胎盘或羊水异常者予以排除。以出生时胎龄为配比标准，按照1∶1进行配对，选取同期在本院接受产前超声检查并且在本院分娩的80例正常单胎妊娠胎儿的临床病历资料纳入对照组(本研究遵循的程序符合本院人体试验委员会所制定的伦理学标准，得到该委员会批准，分组征得受试对象本人的知情同意，并与之签署临床研究知情同意书)。采用回顾性分析方法收集两组胎儿的相关资料进行统计学分析。

结果

①本研究对单纯性SUA胎儿的产前诊断正确率为95.2%(80/84)。②两组孕妇的年龄，孕、产次及合并妊娠期糖尿病(GDM)，妊娠期高血压(GH)等比较，差异均无统计学意义(P>0.05)。③两组新生儿性别比较，差异无统计学意义(P>0.05)。④两者胎儿出生体重及身高的差值比较，差异均有统计学意义(P<0.05)。

结论

SUA胎儿较正常胎儿出生体重轻，身高更矮。

关键词: 单脐动脉, 出生体重, 出生身高, 超声检查，产前
Objective

To determine whether fetuses with an isolated single umbilical artery (SUA) were associated with fetal growth.

Methods

Eighty singleton pregnancies with isolated SUAs diagnosed and delivered from January 2009 to December in our hospital were selected as experimental group. Multiple pregnancies, fetuses with other system malformation and abnormal placenta or amniotic fluid were excluded. For control group, 80 normal singleton pregnancies were searched and paired at a ratio of 1∶1 during the same period in the same hospital The study protocol was approved by the Ethical Review Board of Investigation in Human Being of West China Second University Hospital, Sichuan University. Informed consent was obtained from the parents of each participating neonate.. The statistical analysis was used in two groups collected by retrospective analysis.

Results

①The accuracy of diagnose was 95.2% (80/84) in this study. ②There were no significant differences in age, pregnant, pregnancy, gestational diabetes mellitus(GDM) and gestational hypertension(GH) between two groups (P>0.05). ③No significant difference was observed in neonatal sex between the two groups(P>0.05). ④There were significant differences in birth weight and height between SUA group and control group(P<0.05).

Conclusions

Compared with the normal fetuses, the birth weight is lighter and the birth height is shorter in fetuses with an isolated SUA.

Key words: single umbilical artery, birth weight, birth height, ultrasonography, prenatal
表1 SUA组与对照组胎儿的一般临床资料比较(±s)
Table 1 Comparison of related clinical data between SUA group and control group(±s)
组别 n 孕妇年龄(岁) 孕次 产次 GDM发生率[n(%)] GH发生率[n(%)]
SUA组 80 29.0±3.5 2.1±0.6 1.1±0.4 7(8.8) 2(2.5)
对照组 80 28.1±5.2 1.8±0.5 1.1±0.2 6(7.5) 1(1.3)
t/χ2 ? 3.08 10.78 8.54 3.08 2.99
P ? 0.20 0.07 0.08 0.07 0.07
表2 SUA组与对照组胎儿的围生期结局比较(±s)
Table 2 Comparison of pregnancy outcomes between SUA group and control group(±s)
组别 n 出生体重(kg) 出生身高(cm) 性别[n(%)]
男性 女性
SUA组a 80 2.96±0.06 45.21±0.91 40(50.0) 40(50.0)
对照组b 80 3.21±0.04 47.99±0.32 42(52.5) 38(47.5)
组间差值b-a 80 0.25±0.03 2.78±0.55 ? ?
t/χ2 ? 58.21 43.54 2.23 2.70
P ? 0.012 0.016 0.18 0.10
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