探讨先天性梅毒(CS)的临床特点，以及是否合并TORCH等其他感染与器官损害的关系。

选择2006年2月至2010年10月在本院住院并确诊为CS的75例患儿的临床病历资料为研究对象。按照是否合并TORCH感染，将其分为单纯CS组(n＝39)与CS合并TORCH组(n＝36)。两组患儿年龄、性别等一般资料比较，差异无统计学意义(P>0.05)(本研究遵循的程序符合本院人体试验委员会制定的伦理学标准，得到该委员会批准，分组征得受试对象监护人的知情同意，并与之签署临床研究知情同意书)。对两组患儿在多系统损害和实验室检查结果等方面进行对比分析。

单纯CS组与CS合并TORCH感染组在肝脾大，贫血，血小板计数减少，转氨酶水平升高，低蛋白血症及胸部X射线摄片方面比较，差异有统计学意义(P<0.05)。

合并其他TORCH感染的CS患儿在呼吸系统、消化系统、血液系统的损害的发生率显著增加，转氨酶水平升高更明显，肝损害程度更严重。

To investigate clinical feature of the congenital syphilis (CS) and whether combined with other infections such as TORCH infection and organ damage.

From February 2006 to October 2010, 75 cases diagnosed as CS were included into this study. According to whether with or without TORCH infection, which were divided into pure CS group (n=39) and CS combined with TORCH group (n=36). General data of two groups had no significant difference (P>0.05). This study protocol was approred by the Ethical Review Board of Investigation in Human being of this hospital. Informal consent was obtained from guardians of children. The children in the two groups were compared and analyzed in multiple system lesions and laboratory test results, etc..

In liver hepato splenomegaly, anemia, thrombocytopenia, elevated transaminases, hypoproteinemia and chest X ray, the difference of the children in group CS and group CS with TORCH infection were statistically significant (P<0.05).

The incidence of other organ damage in the respiratory system, digestive system, blood system increased significantly, aminotransferase levels increased obviously, the degree of liver damage was more serious in CS children combined with TORCH infection.