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中华妇幼临床医学杂志(电子版) ›› 2013, Vol. 09 ›› Issue (03) : 384 -387. doi: 10.3877/cma.j.issn.1673-5250.2013.03.028

所属专题: 文献

综述

人类白细胞抗原G在复发性自然流产中的研究进展
余洋1   
  1. 1. 610041 成都,四川大学华西第二医院
  • 收稿日期:2013-01-05 修回日期:2013-04-18 出版日期:2013-06-01

Progress Research of Human Leukocyte Antigen G in Recurrent Miscarriage

Yang YU1   

  1. 1. Department of Gynecology and Obstetrics, West China Second University Hospital, Chengdu 610041, Sichuan Province, China
  • Received:2013-01-05 Revised:2013-04-18 Published:2013-06-01
  • About author:
    (Corresponding author: WANG He, Email: )
引用本文:

余洋. 人类白细胞抗原G在复发性自然流产中的研究进展[J]. 中华妇幼临床医学杂志(电子版), 2013, 09(03): 384-387.

Yang YU. Progress Research of Human Leukocyte Antigen G in Recurrent Miscarriage[J]. Chinese Journal of Obstetrics & Gynecology and Pediatrics(Electronic Edition), 2013, 09(03): 384-387.

人类白细胞抗原G(HLA-G)作为非经典HLA-Ⅰ类分子,以膜结合型和胞质可溶型2类形式存在。HLA-G由于其独特结构和生物学功能,在母胎界面的免疫耐受中发挥重要作用,既能调节正常的妊娠,还与部分病理性妊娠密切相关。笔者拟就HLA-G在复发性自然流产中的研究进展,综述如下。

As non-classical molecular of human leukocyte antigen Ⅰ, human leukocyte antigen G (HLA-G) exist by two isoforms which are membrane-bounded isoform and cytoplasmic soluble isoform. Due to its unique conformation and biologic function, HLA-G plays important role in the maternal-fetus immunologic tolerance, it can regulate the normal process of pregnancy, and also closely associated with some pathological pregnancy. This paper discusses the progress research of HLA-G in recurrent miscarriage.

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