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中华妇幼临床医学杂志(电子版) ›› 2012, Vol. 08 ›› Issue (04) : 512 -514. doi: 10.3877/cma.j.issn.1673-5250.2012.04.035

所属专题: 文献

综述

人乳头瘤病毒感染与宫颈癌的关系及其疫苗的研究进展
严虹月1,*,*(), 曹佩霞2   
  1. 1. 210046 江苏南京,南京中医药大学第一临床医学院
    2. 常州市中医院
  • 收稿日期:2012-04-01 修回日期:2012-06-30 出版日期:2012-08-01
  • 通信作者: 严虹月

Research Progress of Relationship Between Human Papillomavirus Vaccine and Cervical Carcinoma

Hong-yue YAN1(), Pei-xia CAO2   

  1. 1. First Clinical Medical College of Nanjing University of Chinese Medicine, Nanjing 210046, China
  • Received:2012-04-01 Revised:2012-06-30 Published:2012-08-01
  • Corresponding author: Hong-yue YAN
  • About author:
    (Corresponding author: YAN Hong-yue, Email: )
引用本文:

严虹月, 曹佩霞. 人乳头瘤病毒感染与宫颈癌的关系及其疫苗的研究进展[J/OL]. 中华妇幼临床医学杂志(电子版), 2012, 08(04): 512-514.

Hong-yue YAN, Pei-xia CAO. Research Progress of Relationship Between Human Papillomavirus Vaccine and Cervical Carcinoma[J/OL]. Chinese Journal of Obstetrics & Gynecology and Pediatrics(Electronic Edition), 2012, 08(04): 512-514.

人乳头瘤病毒(HPV)的持续感染已被证实是诱发宫颈癌的主要原因,其中高危型HPV(HR-HPV)-16,-18感染可引起70%以上感染者发生宫颈癌和癌前病变。因此,预防HPV感染是防治宫颈癌的主要途径。而HPV疫苗的成功研制,在预防宫颈癌方面取得巨大突破。目前,全球广泛应用的2种HPV疫苗,分别为4价的Gardasil○R(抗HPV-6,-11,-16,-18型,默克公司,美国)和2价的cervarix?(抗HPV-16,-18型;葛兰素史克公司,英国)。本研究拟就HPV感染的致癌机制、流行病学现状及预防性HPV疫苗的作用机制及安全性,综述如下。

It is well accepted today that almost cases of carcinoma of the cervix are caused by persistent infections with human papilloma viruses (HPV), especially high risk HPV(HR-HPV)-16, -18 which accounting for more than 70%. The prevention of HPV infection in the development and progression of cervical carcinoma is very important. The success of HPV vaccine development has made great breakthrough in the prevention of cervical carcinoma. At present, two kinds of HPV vaccine were widely used in the world. They are Gardasil○R (anti-HPV-6, -11, -16, -18, Merck & Co., Inc., USA) and Cervarix? (anti-HPV-16, -18, GlaxoSmithKline, England). This paper focused on the carcinogenesis and epidemiological situation of HPV, the mechanism and safety of preventive HPV vaccine.

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