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中华妇幼临床医学杂志(电子版) ›› 2012, Vol. 08 ›› Issue (04) : 515 -518. doi: 10.3877/cma.j.issn.1673-5250.2012.04.036

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综述

手足口病患儿肠道病毒71感染相关免疫功能变化及其临床意义
孙德宏1, 于永锋1, 赵桂娟1, 张定荣1, 徐书珍1,*,*()   
  1. 1. 266200 山东青岛,山东省即墨市人民医院儿科
  • 收稿日期:2012-02-05 修回日期:2012-05-27 出版日期:2012-08-01
  • 通信作者: 徐书珍

Immune Function Changes of Children With Hand-Foot-Mouth Disease Caused by Enterovirus 71 Infection and Its Clinical Significance

De-hong SUN1, Yong-feng YU1, Gui-juan ZHAO1, Ding-rong ZHANG1, Shu-zhen XU1()   

  1. 1. People's Hospital of Jimo City, Jimo 266200, Shandong Province, China
  • Received:2012-02-05 Revised:2012-05-27 Published:2012-08-01
  • Corresponding author: Shu-zhen XU
  • About author:
    (Corresponding author: XU Shu-zhen, Email: )
引用本文:

孙德宏, 于永锋, 赵桂娟, 张定荣, 徐书珍. 手足口病患儿肠道病毒71感染相关免疫功能变化及其临床意义[J/OL]. 中华妇幼临床医学杂志(电子版), 2012, 08(04): 515-518.

De-hong SUN, Yong-feng YU, Gui-juan ZHAO, Ding-rong ZHANG, Shu-zhen XU. Immune Function Changes of Children With Hand-Foot-Mouth Disease Caused by Enterovirus 71 Infection and Its Clinical Significance[J/OL]. Chinese Journal of Obstetrics & Gynecology and Pediatrics(Electronic Edition), 2012, 08(04): 515-518.

手足口病(HFMD)患儿肠道病毒71 (EV71)感染可导致中枢神经、呼吸系统损害,引发脑炎、急性弛缓性麻痹、脑水肿和心肌炎等,个别重型HFMD患儿病情进展快,易致死亡。HFMD发病机制可能与病毒感染所致免疫功能异常有关,尤其是细胞免疫功能低下。此外,EV71病毒感染导致的全身炎症反应综合征(SIRS)也可能参与HFMD的发病。因此早期对HFMD患儿进行细胞免疫支持治疗,并阻断SIRS发展,对改善预后意义重大。

Children with hand-foot-mouth disease (HFMD) which caused by enterovirus 71 (EV71) can appear central nervous and respiratory system damage. Meanwhile, EV71 can cause encephalitis, brain edema and myocarditis. Some severe cases are prone to death. The pathogenesis of HFMD is likely related to immune disorders caused by EV71 infection. Additional, systemic inflammatory response syndrome (SIRS) may play an important role in attack. As a result, it is necessary for us to take cellular immune support treatment in time and block SIRS development. It is also significant for children with HFMD to improve the prognosis.

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