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中华妇幼临床医学杂志(电子版) ›› 2009, Vol. 05 ›› Issue (04) : 393 -396. doi: 10.3877/cma.j.issn.1673-5250.2009.04.115

论著

纳络酮联合氨茶碱治疗早产儿呼吸暂停疗效观察
梁雪泥, 肖胜涛   
  1. 643000 四川自贡,自贡市妇幼保健院 自贡市妇女儿童医院儿科
  • 出版日期:2009-08-01

Therapeutic Effects of Naloxone Combined With Aminofilina in the Treatment of Premature Infants Apnea

Xue-ni LIANG, Sheng-tao XIAO   

  1. Department of Pediatrics, Maternal and Child Health Hospital of Zigong (Women and children's Hospital of Zigong), Zigong 643000, Sichuan Province, China
  • Published:2009-08-01
引用本文:

梁雪泥, 肖胜涛. 纳络酮联合氨茶碱治疗早产儿呼吸暂停疗效观察[J/OL]. 中华妇幼临床医学杂志(电子版), 2009, 05(04): 393-396.

Xue-ni LIANG, Sheng-tao XIAO. Therapeutic Effects of Naloxone Combined With Aminofilina in the Treatment of Premature Infants Apnea[J/OL]. Chinese Journal of Obstetrics & Gynecology and Pediatrics(Electronic Edition), 2009, 05(04): 393-396.

目的

观察纳络酮联合氨茶碱治疗早产儿呼吸暂停的疗效。

方法

选择2006年1月至2007年12月自贡市妇幼保健院收治并确诊为呼吸暂停的早产儿86例为研究对象。将其随机分为观察组(n=46)和对照组(n=40)(本研究遵循的程序符合自贡市妇幼保健院人体试验委员会制定的伦理学标准,得到该委员会批准,分组征得试验患儿监护人的知情同意,并与其签署临床研究知情同意书)。入院后,对两组患儿均行原发病、保暖、保持呼吸道通畅、纠正低氧血症等对症治疗。在此基础上,观察组先予0.1 mg/kg纳络酮静脉推注,然后按0.1 mg/kg纳络酮+20 mL 10%葡萄糖注射液静脉滴注,每天2次;氨茶碱首次负荷量为5 mg/kg+(10~20)mL 10%葡萄糖注射液,12 h后予2.5 mg/kg维持,每天2次,每天纳络酮、氨茶碱依次交替使用,疗程为3 d。对照组单用氨茶碱治疗,用法同观察组。比较两组疗效。

结果

观察组早产儿呼吸暂停治疗有效率为87%(40/46);对照组为67.5%(27/40),两组比较,差异有显著意义(P<0.05)。

结论

纳络酮联合氨茶碱治疗早产儿呼吸暂停的效果优于单用氨茶碱。

Objective

To observe the therapeutic effects of naloxone combined with aminofilina in the treatment of premature infants apnea.

Methods

From January 2006 to December 2007, 86 cases who were diagnosed as premature infants apnea were randomly divided into observation group (n=46) and control group (n=40). Informed consent was obtained from all participates. Observation group injected naloxone at the dose of 0.1 mg/kg into veins at first, then received naloxone at the dose of 0.1 mg/kg mixed with 20 mL 10% glucose through intervenous drop infusion, twice per day. The first dose of 5 mg/kg for aminofilina mixed with (10~20)mL 10% glucose intravenous drop. Then the dose was reduced and maintained at the level of 2.5 mg/kg each time, twice per day. Treatment methods alternated for 3 days. Control group used aminofilina only, the application was the same as observation group. Therapeutic effects of two groups were compared.

Results

Effective rates of observation group and control group were 87% (40/46), and 67.5%(27/40), respectively. There had statistically significant difference between two groups(P<0.05).

Conclusion

Therapeutic effects of naloxone combination with aminofilina in the treatment of premature infants apnea surpasses aminofilina only.

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