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中华妇幼临床医学杂志(电子版) ›› 2009, Vol. 05 ›› Issue (04) : 397 -400. doi: 10.3877/cma.j.issn.1673-5250.2009.04.116

论著

沙利度胺联合CP方案对晚期卵巢癌血清血管内皮生长因子、 肿瘤坏死因子–α、肿瘤抗原125的影响
李文, 彭芝兰, 田青, 何宇   
  1. 610061 四川成都,解放军第452医院妇产科
    四川大学华西第二医院
  • 出版日期:2009-08-01

Effects of Vascular Endothelial Growth Factor, Tumor Necrosis Factor-α and Cancer Antigen 125 Level by CP Combined With Thalidomide in Treatment of Advanced Ovarian Carcinoma

Wen LI, Zhi-lan PENG, Qing TIAN, Yu He   

  1. Department of Obstetrics and Gynecology, the 452 Hospital of PLA, Chengdu 610061, China
  • Published:2009-08-01
引用本文:

李文, 彭芝兰, 田青, 何宇. 沙利度胺联合CP方案对晚期卵巢癌血清血管内皮生长因子、 肿瘤坏死因子–α、肿瘤抗原125的影响[J/OL]. 中华妇幼临床医学杂志(电子版), 2009, 05(04): 397-400.

Wen LI, Zhi-lan PENG, Qing TIAN, Yu He. Effects of Vascular Endothelial Growth Factor, Tumor Necrosis Factor-α and Cancer Antigen 125 Level by CP Combined With Thalidomide in Treatment of Advanced Ovarian Carcinoma[J/OL]. Chinese Journal of Obstetrics & Gynecology and Pediatrics(Electronic Edition), 2009, 05(04): 397-400.

目的

观察CP方案联合沙利度胺(thalidomide,Thd;反应停)对晚期卵巢癌患者的疗效。

方法

2004年7月至2007年12月,26例在解放军第452医院确诊为晚期卵巢癌患者,将其随机分为A组(CP方案联合沙利度胺,n=13)与B组(单独使用CP方案,n=13) (本研究遵循的程序符合解放军第452医院人体试验委员会所制定的伦理学标准,得到该委员会批准,分组征得受试对象知情同意,并与之签署临床研究知情同意书),比较其疗效。A组用药方案为:(500~700)mg/m2环磷酰胺(cyclophosphamide,CTX)静脉给药+(50~75) mg/m2顺铂(diamminedichloroplatinum,DDP)静脉给药+200 mg沙利度胺口服,每晚1次,连续治疗1个月。B组患者除不口服沙利度胺外,用药方案同A组。采用酶联免疫吸附测定(enzyme linked immunosorbent assay,ELISA)试剂盒检测A,B两组患者血清中血管内皮生长因子(vascular endothelial growth factor,VEGF)、肿瘤坏死因子(tumor necrosis factor,TNF)–α、肿瘤抗原125(cancer antigen 125, CA125)含量。

结果

血清中,血管内皮生长因子、肿瘤抗原125含量A组较B组明显降低,血清中肿瘤坏死因子–α含量也显著降低,两组比较,差异均有显著意义(P<0.01,P<0.05)。

结论

在晚期卵巢癌治疗中,沙利度胺与常规化疗药物有协同作用,可增强常规化疗药物作用。

Objective

To study the drug chemotherapy of CP in combination with thalidomide(Thd) in treatment of advanced ovarian carcinoma.

Methods

From July 2004 to December 2007, 26 cases with advanced ovarian carcinoma was randomly divided into two groups. Group A(n=13) were treated with cyclophosphamide [CTX, (500~700) mg/m2]+ diamminedichloroplatinum [DDP, (50~75) mg/m2]+ thalidomide (200 mg/d), and group B were treated with cyclophosphamide[(500~700) mg/m2]+ diamminedichloroplatium [(50~75) mg/m2]. Informed consent was obtained from all participants. Vascular endothelial growth factor (VEGF), tumor necrosis factor (TNF)-α, and cancer antigen (CA)125 level in serum were determined by enzyme-linked inmunonosorbent assay(ELISA) in two groups.

Results

The level of vascular endothelial growth factor, cancer antigen125 in group B were significantly lower than those of group A, and the level of tumor necrosis factor-α of group B was significant lower than that of group A after treatment(P<0.01, P<0.05).

Conclusion

Thalidomide might prove the antitumor drug therapy on advanced ovarian carcinoma.

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