探讨戊酸雌二醇和卡前列甲酯栓在绝经后妇女取宫内节育器(intrauterine contraceptive device，IUD)时的应用效果。

采取回顾性研究法，将2003年7月至2008年11月498例绝经后妇女按照取宫内节育器时采取措施不同分为4组：A组(n＝148)应用戊酸雌二醇；B组(n＝117)取器前应用卡前列甲酯栓；C组(n＝130)取器前应用戊酸雌二醇配伍卡前列甲酯栓；对照组(n＝103)取器前不使用任何药物。

取宫内节育器效果：A，B，C组取宫内节育器成功率明显高于对照组，差异有显著意义(P<0.01)；A组与B组比较，差异无显著意义(P>0.05)；C组成功率明显高于A，B组，差异有显著意义(P<0.01)。

采取戊酸雌二醇配伍卡前列甲酯栓措施的取器成功率为100%，明显高于单独应用戊酸雌二醇或卡前列甲酯栓。

To discuss clinical effects on estradiol valerate combinded with methyl carprost suppository in removal of intrauterine contraceptive device(IUD) of menopausal women.

From July 2003 to November 2008, 498 cases of menopausal women who removed intrauterine contraceptive device were randomly divided into 4 groups according to retrospective study. Group A(n=148) took estradiol valerate, group B(n=117) applied methyl carprost suppository, group C(n=130) applied estradiol valerate and methyl carprost suppository, and control group(n=113) took no drug.

The successful rate of removing intrauterine contraceptive device of group A, B and C were significantly higher than that of control group(P<0.01). There was no significant difference between group A and B(P>0.05). The successful rate of removing intrauterine contraceptive device of group C was significantly higher than that of group A and B(P<0.01).

Application of estradiol valerate combined with methyl carprost suppository to remove intrauterine contraceptive device of menopause women is safe and effective.