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中华妇幼临床医学杂志(电子版)

Chinese Journal of Obstetrics & Gynecology and Pediatrics(Electronic Edition) ›› 2022, Vol. 18 ›› Issue (06): 627 -633. doi: 10.3877/cma.j.issn.1673-5250.2022.06.002

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Research progress on early screening for congenital cytomegalovirus infection

Dongming Li1,2, Sheng He2,3,†()   

  1. 1Department of Clinical Laboratory, Maternal and Children Health Hospital of Guangxi Zhuang Autonomous Region, Nanning 530012, Guangxi Zhuang Autonomous Region, China
    2Birth Defects Prevention and Control Institute of Guangxi Zhuang Autonomous Region, Nanning 530012, Guangxi Zhuang Autonomous Region, China
    3Key Laboratory of Basic Research for Guangxi Birth Defects Control and Prevention, Nanning 530012, Guangxi Zhuang Autonomous Region, China
  • Received:2022-03-19 Revised:2022-09-20 Published:2022-12-01
  • Corresponding author: Sheng He
  • Supported by:
    Guangxi Medical High-level Backbone Talents " 139" Plan Project(G202003023); Guangxi Key Laboratory of Reproductive Health and Birth Defect Prevention and Control Funding Project(21-220-22); National Key Research and Development Program(2019YFC0121901)
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Congenital cytomegalovirus (cCMV) infection is an important cause of sensorineural hearing loss (SNHL) and neurodevelopmental abnormalities in infants. In many countries, cCMV infection causes more diseases than other congenital diseases detected by newborn screening. cCMV infection has become a global public health problem. At present, neonatal cytomegalovirus (CMV) infection screening program has not been implemented in China. Therefore, cCMV infection cases often cannot be diagnosed and treated in time. In order to prevent the occurrence of severe neonatal sequelae caused by cCMV infection, early screening of cCMV infection is very important. The author elaborates on current research status of epidemical characteristics, diagnosis and early screening program of neonatal cCMV infection.

Key words: Cytomegalovirus, Cytomegalovirus infections, congenital, Hearing tests, Hearing loss, sensorineural, Neonatal screening, Infant, newborn
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