Hepcidin and premature infants with iron deficiency anemia: a comprehensive review

doi:10.3877/cma.j.issn.1673-5250.2021.02.001

Iron deficiency anemia (IDA) is one of the most important challenges for premature infants, which seriously affects their physical growth, immune function and nervous system development. There is no unified international standard for diagnosis and treatment of premature infants with IDA, as well as the lack of specific indicators for early diagnosis of IDA in premature infants. At present, results of studies have shown that hepcidin detection can specifically reflect changes of iron status in preterm infants at an early stage, and can be used for early diagnosis of IDA in preterm infants with high sensitivity and specificity. It can also provide reference for clinical development of more accurate diagnosis and treatment programs for preterm infants with IDA. However, there are few relevant studies about relationship between hepcidin and iron metabolism in preterm infants and its value in diagnosis and treatment of IDA in preterm infants. This review intends to elaborate on the latest progresses of relationships between hepcidin and IDA in premature infants from aspects of mechanism of hepcidin, effect of iron metabolism in pregnant women on hepcidin of premature infants, significance of hepcidin in diagnosis and treatment of premature infants with IDA, and relationship between hepcidin and iron overload.

Key words: Anemia, iron-deficiency, Hemoglobins, Hepcidin, Iron metabolism disorders, Iron overload, Erythropoietin, Infant, premature

图1 影响铁调素表达的主要因素

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