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中华妇幼临床医学杂志(电子版)

Chinese Journal of Obstetrics & Gynecology and Pediatrics(Electronic Edition) ›› 2020, Vol. 16 ›› Issue (05): 510 -518. doi: 10.3877/cma.j.issn.1673-5250.2020.05.003

Special Issue: ；

Forum

Current status of diagnosis and treatment of twin-twin transfusion syndrome and its influence on prognosis of neonates

Xuan Yang1, Jun Tang1,†()   

  1. 1. Department of Pediatrics, Key Laboratory of Birth Defects and Related Diseases of Women and Children, Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China
  • Received:2020-05-06 Revised:2020-09-01 Published:2020-10-01
  • Corresponding author: Jun Tang
  • Supported by:
    Construction Project of National Key Clinical Specialty (Pediatrics and Neonatal Specialty)(1311200003303)
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Twin-twin transfusion syndrome (TTTS) is one of the serious complications of twin pregnancy with monochorionicdiamniotic (MCDA). Research on pathogenesis of TTTS mainly focuses on abnormal vascular anastomosis of placenta, differences of angiogenic factors in plasma, related gene levels and epigenetics of TTTS. Prenatal ultrasound is an important diagnosis method for twin pregnancy of MCDA and TTTS pregnant in the first trimester.Results of study show that fetal endoscopic laser coagulation is an effective measure to prolong gestational age of twin pregnancy fetuses and improve their prognosis. There are differences in complications between survival donors and recipients of TTTS, and different prenatal treatment methods also lead to different prognosis. In this paper, authors will focus on the latest research progresses on pathogenesis of TTTS, perinatal diagnosis, treatment, and impact on neonatal outcomes.

Key words: Twin-twin transfusion syndrome, Monochorionicdiamniotic, Diseases in twins, Perinatal care, Pathogenesis, Prognosis of neonates, Perinatal treatment, Laser coagulation, Multiple birth offspring
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