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中华妇幼临床医学杂志(电子版)

Chinese Journal of Obstetrics & Gynecology and Pediatrics(Electronic Edition) ›› 2020, Vol. 16 ›› Issue (03): 249 -256. doi: 10.3877/cma.j.issn.1673-5250.2020.03.001

Special Issue: ；

Healthy People, Healthy Society

Current status of prevention and treatment of neonatal meconium aspiration syndrome

Li Liu1, Jun Tang1,†()   

  1. 1. Department of Pediatrics, Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China
  • Received:2020-02-22 Revised:2020-05-09 Published:2020-06-01
  • Corresponding author: Jun Tang
  • About author:
    Corresponding author: Tang Jun, Email:
  • Supported by:
    National Natural Science Foundation of China(81300524, 81630038, 81771643, 81971433, 81971428); National Major Program of Ministry of Science and Technology of China(2017YFA0104200); Fund of National Clinical Key Specialties Development (Neonatology)(1311200003303); Science and Technology Planning Project of Science and Technology Department of Sichuan Province(2016TD0002)
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Neonatal meconium aspiration syndrome (MAS) is a life-threatening respiratory disease with high mortality. MAS can lead to respiratory failure, air leakage syndrome, persistent pulmonary hypertension, multiple organ function damage and other serious complications. In recent years, with the development of perinatal technology, the diagnosis and treatment of MAS has been continuously improved, thus increasing the survival rate of children with MAS. The authors intend to review the latest research status of prevention and treatment of MAS, in order to explore the effects of prenatal and intrapartum management, drug therapy, respiratory support therapy, inhaled nitric oxide (iNO), technology of extracorporeal membrane oxygenation (ECMO), mild hypothermia therapy and other related measures on the prognosis of children with MAS.

Key words: Meconium aspiration syndrome, Pulmonary surfactant-associated proteins, Nitric oxide, Administration, inhalation, Hypothermia, induced, Continuous positive airway pressure, Extracorporeal membrane oxygenation, Infant, newborn
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