Chinese Medical E-ournals Database

Chinese Journal of Obstetrics & Gynecology and Pediatrics(Electronic Edition) ›› 2019, Vol. 15 ›› Issue (01): 116 -120. doi: 10.3877/cma.j.issn.1673-5250.2019.01.020

Special Issue:

Review

Research progress on effects of maternal intestinal flora disturbance and its intrauterine translocation on mother and fetus

Lijuan Lyu1, Hui Li1, Wei He1, Hongli Duan1, Aihua Yin1,()   

  1. 1. Department of Obstetrics, Guangdong Women′s and Children′s Hospital, Guangzhou 511400, Guangdong Province, China
  • Received:2018-09-08 Revised:2019-01-03 Published:2019-02-01
  • Corresponding author: Aihua Yin
  • About author:
    Corresponding author: Yin Aihua, Email:
  • Supported by:
    Key Project for Prevention and Control of Reproductive Health and Major Birth Defects of National Key Research and Development Program of China in 2016(2016YFC1000703)

Recent studies have shown that bacteria exist in the uterus and may affect the fetus. So far, the specific mechanism of flora translocation between mother and fetus has not been clarified. Besides maternal blood, placenta and amniotic fluid, maternal intestinal tract may also be one of the main sources of fetal intestinal flora. The maternal intestinal flora is translocated to the uterus through blood and other means, and then translocated to the fetal gut and immune system via the placental blood circulation and amniotic fluid. The abnormal composition and quantity of intestinal flora during pregnancy can lead to obesity, abnormal development of nerve system and abnormal blood pressure regulation of the mother and fetus after birth. With the development of gene sequencing technology, the relationship between maternal intestinal flora disturbance and its intrauterine translocation and maternal-fetal diseases can be further explored, thus providing theoretical basis for prevention and intervention of fetal diseases. The author intends to review the research progress on the effects of maternal intestinal flora disturbance and its intrauterine translocation on the mother and fetus.

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