Postpartum hemorrhage (PPH) is a serious complication during delivery, and PPH caused by uterine contraction fatigue is the most common kind of PPH. In recent years, the incidence of placenta factors, such as of placenta previa and placenta increta, has been increasing year by year, resulting an increase in the incidence of PPH which can be diagnosed as early as possible via varieties of auxiliary examination means (ultrasound, MRI, cystoscope), to evaluate the pathogenetic conditions and develop individualized therapy strategies, thereby reducing the incidence of PPH. Recent studies on the pathogenesis of PPH suggest that the Universal Two-Child Policy in China and choice of vaginal delivery after cesarean section may increase the incidence of PPH caused by placental factors. For the diagnosis of PPH, the most recent method is not only based on the volume of blood loss during delivery, but also on hemodynamic changes. Currently, the individualized treatment of PPH with strategies of drug therapy, surgical treatment and interventional therapy have achieved good clinical efficacy. The article focuses on the latest advances in etiology, diagnosis and treatment of PPH.