Chinese Medical E-ournals Database

Chinese Journal of Obstetrics & Gynecology and Pediatrics(Electronic Edition) ›› 2018, Vol. 14 ›› Issue (03): 360 -367. doi: 10.3877/cma.j.issn.1673-5250.2018.03.018

Special Issue:

Review

Progress of neonatal severe hyperbilirubinemia therapies

Min Ge1, Jun Tang1,()   

  1. 1. Department of Neonatology, Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China
  • Received:2018-01-17 Revised:2018-03-29 Published:2018-06-01
  • Corresponding author: Jun Tang
  • About author:
    Corresponding author: Tang Jun, Email:

The incidence of hyperbilirubinemia (HB) is high in newborns. It is one of the most common diseases in newborns requiring hospitalization. If not promptly treated, neonatal severe HB may cause significant complications such as bilirubin encephalopathy, athetoid cerebral palsy, sensorineural hearing loss, ocular motility disorders, dental enamel dysplasia and even death, due to the neurotoxicity of high level of serum total bilirubin. So rapid and effective neonatal severe HB treatment is particularly necessary. Currently, the main treatment methods of neonatal severe HB include phototherapy (PT), exchange transfusion and drug therapy. With the progress of research on neonatal severe HB, attention has been paid to the effectiveness and safety of exchange transfusion and intensive phototherapy (IPT). At the same time, some adjuvant therapies such as probiotics, Yinzhihuang, and body touch also are research hotspots of this field. In this paper, we review the recent literature on therapies of neonatal severe HB, and summarize the latest research progress to provide reference for clinicians in the treatment of neonatal severe HB.

表1 出生体重<2 500 g早产儿生后不同时间需实施光照疗法的血清总胆红素值参考标准
图1 出生胎龄≥35周的晚期早产儿和足月儿生后不同时间需实施光照疗法的血清总胆红素值-日龄曲线
表2 出生体重<2 500 g的早产儿生后不同时间需实施换血疗法治疗的血清总胆红素值参考标准
图2 出生胎龄≥35周晚期早产儿和足月儿生后不同时间需实施换血疗法的血清总胆红素值-日龄曲线
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