Chinese Medical E-ournals Database

Chinese Journal of Obstetrics & Gynecology and Pediatrics(Electronic Edition) ›› 2017, Vol. 13 ›› Issue (05): 606 -610. doi: 10.3877/cma.j.issn.1673-5250.2017.05.019

Special Issue:

Review

Roles of PI3K-Akt3 signaling pathway during cardiac development

Tao Chen1, Haitao Gu1,()   

  1. 1. Department of Pediatric Cardiothoracic Surgery, First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, Jiangsu Province, China
  • Received:2017-05-07 Revised:2017-08-21 Published:2017-10-01
  • Corresponding author: Haitao Gu
  • About author:
    Corresponding author: Gu Haitao, Email:

PI3K-Akt3 is a highly conservative signaling pathway, which exists widely in eukaryotes. PI3K-Akt3 signaling pathway plays an important role during cardiac development through the following ways: promoting cardiomyocyte growth and survival, promoting coronary angiogenesis, enhancing cardiac contractility, regulating signal transduction, inducing autophagy. In this review, we focus on the recent research progress about the roles of PI3K-Akt3 signaling pathway during cardiac development.

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