Chinese Medical E-ournals Database

Chinese Journal of Obstetrics & Gynecology and Pediatrics(Electronic Edition) ›› 2017, Vol. 13 ›› Issue (01): 56 -60. doi: 10.3877/cma.j.issn.1673-5250.2017.01.010

Special Issue:

Original Article

Analysis of non-high-density-lipoprotein-cholesterol in primary and middle school students of Science City Area, Mianyang, Sichuan Province

Yibin Deng1, Lian Ye2,(), Huimin Wang1, Qin Su3, Kun Fang2, Yurong Xiao1, Xing Jiang2, Pan Pan1, Liping Zhang2   

  1. 1. Department of Pediatrics, Sichuan Science City Hospital, Mianyang 621900, Sichuan Province, China
    2. Department of Clinical Laboratory, Sichuan Science City Hospital, Mianyang 621900, Sichuan Province, China
    3. Department of Pediatrics, First People′s Hospital of Longquanyi District of Chengdu City, Chengdu 610100, Sichuan Province, China
  • Received:2016-08-27 Revised:2017-01-07 Published:2017-02-01
  • Corresponding author: Lian Ye
  • About author:
    Corresponding author: Ye Lian, Email:
Objective

To explore the level of non-high-density-lipoprotein-cholesterol (non-HDL-C) and prevalence of non-HDL-C hyperlipidemia in primary and middle school students of Science City Area, Mianyang, Sichuan Province.

Methods

From September to November 2015, a total of 3 241 cases of primary and middle school students of Science City Area, Mianyang, Sichuan Province were selected as research objects by cluster sampling method. According to the body mass index (BMI) growth curve of 0-18 years old children and adolescents in China, they were divided into obese group (n=326), overweight group (n=508) and control group (n=2 407). The age, body height, body weight and lipid level of the students were collected by cross-sectional study method. A total of 3 mL elbow vein blood was collected and the lipid level was detected. The level of non-HDL-C and prevalence of non-HDL-C hyperlipidemia among 3 groups were compared by statistical methods. Before surveying, the informed consents were obtained from guardians of all the students. There were no statistical differences among 3 groups in the age, gender ratio and so on (P>0.05).

Results

①The effective rate of data collection was 99.3% (3 241/3 263). ②Among the 3 241 cases of primary and middle school students, the level of non-HDL-C was (2.46±0.63) mmol/L, the cutoff value of non-HDL-C hyperlipidemia was 3.58 mmol/L. The level of non-HDL-C in female students was (2.51±0.61) mmol/L, which was higher than (2.51±0.61) mmol/L in male students, and the difference was statistically significant (t=3.14, P<0.001). ③There was statistical difference among 3 groups in the level of non-HDL-C (F=85.04, P<0.001). And the levels of non-HDL-C in obese group and overweight group were higher than that in control group, and the level of non-HDL-C in overweight group was also higher than that in control group, all the differences were statistically significant (P<0.001). ④Among the 3 241 cases of primary and middle school students, the prevalence of non-HDL-C hyperlipidemia was 3.6% (116/3 241). There was no statistical difference in the prevalence of non-HDL-C hyperlipidemia between male and female students which was 3.3% (53/1 617) and 3.8% (62/1 624), respectively (χ2=0.54, P=0.462). The prevalence of non-HDL-C hyperlipidemia in obese group was 9.5% (31/326), which was higher than 3.7% (19/508) in overweight group and 2.7% (66/2 407) in control group, and both the differences were statistically significant (χ2=11.73, P<0.001; χ2=38.41, P<0.001). But there was no statistical difference in the prevalence of non-HDL-C hyperlipidemia between overweight group and control group (χ2=1.48, P=0.224).

Conclusions

The level of non-HDL-C in primary and middle school students of Science City Area, Mianyang, Sichuan Province is unoptimistic, and appropriate interventions should be taken to prevent the occurrence of non-HDL-C hyperlipidemia.

表1 3组中、小学生非高密度脂蛋白胆固醇水平比较(mmol/L, ±s)
表2 3组中、小学生高非高密度脂蛋白胆固醇血症患病率比较[例数(%)]
[1]
马军,蔡赐河,王海俊,等. 1985-2010年中国学生超重与肥胖流行趋势[J]. 中华预防医学杂志,2012, 46(9): 776-780.
[2]
侯冬青,赵小元,段佳丽,等. 不同肥胖程度儿童罹患心血管代谢异常风险的横断面调查[J]. 中国循证儿科杂志,2014, 9(2): 101-106.
[3]
Yang G, Wang Y, Zeng Y, et al. Rapid health transition in China, 1990-2010: findings from the Global Burden of Disease Study 2010[J]. Lancet, 2013, 381(9882): 1987-2015.
[4]
李辉,季成叶,宗心南,等. 中国0~18岁儿童、青少年体块指数的生长曲线[J]. 中华儿科杂志,2009, 47(7): 493-498.
[5]
《中华儿科杂志》编辑委员会,中华医学会儿科学分会儿童保健学组,中华医学会儿科学分会心血管学组,中华医学会心血管病学分会动脉粥样硬化学组. 儿童青少年血脂异常防治专家共识[J]. 中华儿科杂志,2009, 47(6): 426-428.
[6]
Wang Y, Lim H. The global childhood obesity epidemic and the association between socio-economic status and childhood obesity[J]. Int Rev Psychiatry, 2012, 24(3): 176-188.
[7]
Boekholdt SM, Amenault BJ, Mora S, et al. Association of LDL cholesterol, non-HDL-cholesterol,and apolipoprotein B levels with risk of cardiovascular events among patients treated with statins: a Meta-analysis[J]. JAMA, 2012, 307(12): 1302-1309.
[8]
Graham I, Atar D, Borch-Johnsen K, et al. European guidelines on cardiovascular disease prevention in clinical practice: executive summary. Fourth Joint Task Force of the European Society of Cardiology and other societies on cardiovascular disease prevention in clinical practice (constituted by representatives of nine societies and by invited experts)[J]. Eur J Cardiovasc Prev Rehabil, 2007, 14(Suppl 2): E1-E40.
[9]
Davidson MH, Maki KC, Pearson TA, et al. Results of the National Cholesterol Education (NCEP) Program Evaluation Project Utilizing Novel E-Technology (NEPTUNE) Ⅱ survey and implications for treatment under the recent NCEP Writing Group recommendations[J]. Am J Cardiol, 2005, 96(4): 556-563.
[10]
陈联辉,施锡锋,梁黎. 非高密度脂蛋白胆固醇的临床意义及其在儿科中的应用[J]. 中华儿科杂志,2013, 51(6): 436-438.
[11]
Expert Panel on Integrated Guidelines for Cardiovascular Health and Risk Reduction in Children and Adolescents, National Heart, Lung, and Blood Institute. Expert panel on integrated guidelines for cardiovascular health and risk reduction in children and adolescents: summary report[J]. Pediatrics, 2011, 128(Suppl 5): S213-S256.
[12]
中华医学会儿科学分会内分泌遗传代谢学组,中华医学会儿科学分会心血管学组,中华医学会儿科学分会儿童保健学组. 中国儿童青少年代谢综合征定义和防治建议[J]. 中华儿科杂志,2012, 50(6): 420-422.
[13]
Srinivasan SR, Frontini MG, Xu J, et al. Utility of childhood non-high-density lipoprotein cholesterol levels in predicting adult dyslipidemia and other cardiovascular risks: the Bogalusa Heart Study[J]. Pediatrics, 2006, 118(1): 201-206.
[14]
Boekholdt SM, Arsenault BJ, Mora S, et al. Association of LDL cholesterol, non-HDL cholesterol, and apolipoprotein B levels with risk of cardiovascular events among patients treated with statins: a meta-analysis[J]. JAMA, 2012, 307(12): 1302-1309.
[15]
焦朝艳,刘戈力,鲍鹏丽,等. 肥胖儿童non-HDL-C、remnant cholesterol与亚临床动脉粥样硬化的关系[J]. 天津医科大学学报,2014, 20(1): 25-28.
[16]
陈联辉,朱伟芬,梁黎,等. 非高密度脂蛋白胆固醇对肥胖儿童非脂性心血管疾病危险因素的预测作用[J]. 中国当代儿科杂志,2013, 15(5): 356-360.
[17]
杨晓莉,马春明,陆强. 秦皇岛地区青少年高非高密度脂蛋白胆固醇血症危险因素分析[J]. 中国学校卫生,2015, 36(7): 1061-1063.
[18]
朱建芳,梁黎,傅君芬,等. 中国6市7~16岁中小学生血脂水平现状调查[J]. 中华流行病学杂志,2012, 33(10): 1005-1009.
[19]
邱吉凤,付淑珍,吴卫萍. 浙江省龙泉市山区儿童青少年肥胖与代谢综合征流行病学研究[J]. 中国基层医药,2015, 22(8): 1139-1142.
[20]
施锡锋. 中国儿童青少年非高密度脂蛋白水平及其预测代谢综合征的异常界值研究[J]. 杭州:浙江大学,2013.
[21]
Li C, Ford ES, McBride PE, et al. Non-high-density lipoprotein cholesterol concentration is associated with the metabolic syndrome among US youth aged 12-19 years[J]. J Pediatr, 2011, 158(2): 201-207.
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