Chinese Medical E-ournals Database

Chinese Journal of Obstetrics & Gynecology and Pediatrics(Electronic Edition) ›› 2016, Vol. 12 ›› Issue (04): 453 -457. doi: 10.3877/cma.j.issn.1673-5250.2016.04.015

Special Issue:

Review

Research progress of roles of vascular endothelial growth factor in hypoxic-ischemic encephalopathy

Xue Fan1, Yi Qu1, Dezhi Mu1   

  1. 1. Department of Pediatrics, West China Second University Hospital, Sichuan University; Key Laboratory of Birth Defects and Related Diseases of Women and Children, Ministry of Education; Key Laboratory of Development and Related Diseases of Women and Children, Chengdu 610041, Sichuan Province, China
  • Received:2016-04-10 Revised:2016-06-20 Published:2016-08-01
  • About author:
    Corresponding author: Tang Jun, Email:

Hypoxic-ischemic encephalopathy (HIE) is a common cause of neonatal mortality and neurological disability among survivors. Vascular endothelial growth factor (VEGF) expression increased after hypoxic-ischemic brain damage (HIBD). The biological roles of VEGF are associated with promoting vascular permeability, enhancing angiogenesis and improving neurological recovery, and VEGF is concerned with various pathophysiological of HIE. This paper focuses on the role of VEGF in HIE, discussing the administration route, time and dosage of VEGF in treatment of HIE, in order to avoid the negative effect and give full play to the cerebral protective effect.

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