Clinical research on the effectiveness of oral administration glucose solution for pain relief during screening of retinopathy of prematurity in preterm infants

doi:10.3877/cma.j.issn.1673-5250.2016.04.012

Objective

To explore the effects of oral administration glucose solution for pain relief during screening of retinopathy of prematurity(ROP) in preterm infants.

Methods

The study was conducted in the neonatal intensive care units(NICU) of Children′s Hospital of Shanghai from 1 August 2014 to 31 July 2015. A total of 95 preterm infants who need ROP screening enrolled in the current study, were randomly divided into the experimental group(n=45) and the control group(n=50) in accordance with random number table. The preterm infants in experimental group were continuing given oral administration 25% glucose solution while the preterm infants in control group were fasting during ROP screening. Evaluated the pain degree of the preterm infants during the procedure by the premature infant pain profile(PIPP). The differences of heart rates, oxygen saturation and PIPP scores between the preterm infants in two groups and between male and female preterm infants in each group were statistically compared. There were no significant differences between two groups of preterm infants in general clinical data (P>0.05). This study followed the Ethics Standards of Human Trial Committee of Children′s Hospital of Shanghai, and was approved by the Human Trial Committee. All parents signed the informed consents.

Results

①While accepting ROP screening, the heart rates and PIPP scores of the preterm infants in experimental group[(149.6±5.0) beats/min, (12.6±1.0) points] were lower than those of control group[(173.3±6.8) beats/min, (15.8±0.9) points], but oxygen saturation of the experimental group[(94.7±0.9)%] was higher than that of control group[(90.1±1.2)%]. and all the differences above were statistically significant(P<0.01). ②In experimental group or control group, there were no significant differences between male and female preterm infants in heart rates, oxygen saturation and PIPP scores during ROP screening(P>0.05).

Conclusions

Oral administration 25% glucose solution during ROP screening was an effective measure for pain relief for the preterm infant.

Key words: Administration, oral, Glucose, Analgesia, Retinopathy of prematurity, Mass screening, Pain measurement, Infant, premature

表1 两组早产儿一般临床资料比较(±s)

组别	例数	出生体重(g)	1 min Apgar评分(分)	5 min Apgar评分(分)	胎龄(周)	纠正胎龄(周)	筛查时年龄(周)
实验组	45	1 212±80	6.0±0.9	8.0±0.6	34.1±1.1	38.8±1.3	4.6±0.5
对照组	50	1 226±73	6.0±1.1	8.2±0.6	34.4±1.2	39.0±1.3	4.6±0.5
检验值	?	t＝0.86	t＝0.20	t＝1.29	t＝1.03	t＝1.01	t＝0.15
P值	?	0.39	0.84	0.20	0.31	0.32	0.88
组别	例数	筛查时体重(g)	基础心率(次/min)	基础血氧饱和度(%)	筛查操作时间(min)	基础PIPP评分(分)	性别构成比[例数(%)]
组别	例数	筛查时体重(g)	基础心率(次/min)	基础血氧饱和度(%)	筛查操作时间(min)	基础PIPP评分(分)	男	女
实验组	45	2 332±75	138.3±3.5	96.8±0.8	2.2±0.6	4.2±0.5	24(53.3)	21(46.7)
对照组	50	2 335±70	140.0±4.0	96.6±0.8	2.1±0.5	4.1±0.6	21(42.0)	29(58.0)
检验值	?	t＝0.39	t＝2.24	t＝1.00	t＝1.13	t＝0.56	χ²＝1.22
P值	?	0.70	0.22	0.32	0.26	0.58	0.27

表1 两组早产儿一般临床资料比较(±s)

组别	例数	出生体重(g)	1 min Apgar评分(分)	5 min Apgar评分(分)	胎龄(周)	纠正胎龄(周)	筛查时年龄(周)
实验组	45	1 212±80	6.0±0.9	8.0±0.6	34.1±1.1	38.8±1.3	4.6±0.5
对照组	50	1 226±73	6.0±1.1	8.2±0.6	34.4±1.2	39.0±1.3	4.6±0.5
检验值	?	t＝0.86	t＝0.20	t＝1.29	t＝1.03	t＝1.01	t＝0.15
P值	?	0.39	0.84	0.20	0.31	0.32	0.88
组别	例数	筛查时体重(g)	基础心率(次/min)	基础血氧饱和度(%)	筛查操作时间(min)	基础PIPP评分(分)	性别构成比[例数(%)]
组别	例数	筛查时体重(g)	基础心率(次/min)	基础血氧饱和度(%)	筛查操作时间(min)	基础PIPP评分(分)	男	女
实验组	45	2 332±75	138.3±3.5	96.8±0.8	2.2±0.6	4.2±0.5	24(53.3)	21(46.7)
对照组	50	2 335±70	140.0±4.0	96.6±0.8	2.1±0.5	4.1±0.6	21(42.0)	29(58.0)
检验值	?	t＝0.39	t＝2.24	t＝1.00	t＝1.13	t＝0.56	χ²＝1.22
P值	?	0.70	0.22	0.32	0.26	0.58	0.27

表2 两组早产儿接受ROP筛查时心率、血氧饱和度及PIPP评分比较(±s)

组别	例数	心率(次/min)	血氧饱和度(%)	PIPP评分(分)
实验组	45	149.6±5.0	94.7±0.9	12.6±1.0
对照组	50	173.3±6.8	90.1±1.2	15.8±0.9
t值	?	19.24	21.70	46.68
P值	?	0.000	0.000	0.000

表2 两组早产儿接受ROP筛查时心率、血氧饱和度及PIPP评分比较(±s)

组别	例数	心率(次/min)	血氧饱和度(%)	PIPP评分(分)
实验组	45	149.6±5.0	94.7±0.9	12.6±1.0
对照组	50	173.3±6.8	90.1±1.2	15.8±0.9
t值	?	19.24	21.70	46.68
P值	?	0.000	0.000	0.000

表3 两组不同性别早产儿接受ROP筛查时心率、血氧饱和度及PIPP评分比较(±s)

性别	实验组				对照组
性别	例数	心率(次/min)	血氧饱和度(%)	PIPP评分(分)	例数	心率(次/min)	血氧饱和度(%)	PIPP评分(分)
男	24	150.1±5.2	94.4±0.9	12.6±1.1	21	173.0±7.7	90.0±1.2	15.7±1.1
女	21	149.1±4.9	94.9±0.7	12.5±1.0	29	173.6±6.0	90.2±1.2	15.8±0.8
t值	?	0.70	2.03	0.21	?	0.30	0.72	0.55
P值	?	0.490	0.310	0.420	?	0.380	0.240	0.290

表3 两组不同性别早产儿接受ROP筛查时心率、血氧饱和度及PIPP评分比较(±s)

性别	实验组				对照组
性别	例数	心率(次/min)	血氧饱和度(%)	PIPP评分(分)	例数	心率(次/min)	血氧饱和度(%)	PIPP评分(分)
男	24	150.1±5.2	94.4±0.9	12.6±1.1	21	173.0±7.7	90.0±1.2	15.7±1.1
女	21	149.1±4.9	94.9±0.7	12.5±1.0	29	173.6±6.0	90.2±1.2	15.8±0.8
t值	?	0.70	2.03	0.21	?	0.30	0.72	0.55
P值	?	0.490	0.310	0.420	?	0.380	0.240	0.290

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