Chinese Medical E-ournals Database

Chinese Journal of Obstetrics & Gynecology and Pediatrics(Electronic Edition) ›› 2015, Vol. 11 ›› Issue (06): 798 -800. doi: 10.3877/cma.j.issn.1673-5250.2015.06.025

Special Issue:

Review

Research progress of immune factors in intrahepatic cholestasis of pregnancy

Yan Kong1   

  1. 1. Department of Obstetrics and Gynecology, Clinical Medical College, Yangzhou University, Yangzhou 225001, Jiangsu Province, China
  • Received:2015-10-08 Revised:2015-11-10 Published:2015-12-01
  • About author:
    Corresponding author: Kong Xiang, Email:

Intrahepatic cholestasis of pregnancy(ICP) is a common obstetric disease. It has adverse effects on the fetus. Its etiology and pathogenesis are unclear now. Immune factors are thought to participate in pathogenesis of ICP. In T helper cells (Th), the immune balance of Th1/Th2 shifted towards Th1 is an important part of the pathogenesis of ICP. Th17 secreting excess interleukin(IL)-17, macrophages secreting a lot of tumor necrosis factor (TNF)-α, lower function of regulatory T cells(Treg), lower expression of human leukocyte antigen (HLA) and interacting with other cytokines lead to its pathogenesis. The relationship between the development of ICP and the immune system will be summarized.

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