Chinese Medical E-ournals Database

Chinese Journal of Obstetrics & Gynecology and Pediatrics(Electronic Edition) ›› 2015, Vol. 11 ›› Issue (05): 584 -588. doi: 10.3877/cma.j.issn.1673-5250.2015.05.007

Special Issue:

Original Article

Comparison of clinical outcomes of controlled ovarian stimulation with different gonadotropin

Xiaman Huang1, Fangle Gu1, Fang Lyu1, Yu Pan1, Xiaomei Zhang1()   

  1. 1. Reproductive Medicine Center of Clinical Medical School of Yangzhou University, Yangzhou 225001, Jiangsu Province, China
  • Received:2015-06-12 Revised:2015-08-09 Published:2015-10-01
  • Corresponding author: Xiaomei Zhang
  • About author:
    Corresponding author: Zhang Xiaomei, Email:
Objective

To investigate differences in clinical outcomes of ovulation by different gonadotropin (Gn), including recombinant human follicle stimulating hormone (rFSH) and urinary FSH (uFSH).

Methods

A total of 396 cases of patients undergoing in vitro fertilization/intra-cytoplasmic sperm injection and embryo transfer (IVF/ICSI-ET)in Reproductive Medicine Center of Clinical Medical School of Yangzhou University from January 2011 to December 2013, a total of 428 cycles were collected as the research object. According to different types of Gn, the patient were divided into rFSH group (253 cycles) and uFSH group (175 cycles). General data, Gn dosage, number of Gn days, number of oocytes, the number of high-quality eggs, implantation rate, the incidence of adverse outcomes, pregnancy, live birth rate, abortion rate, multiple pregnancies and the incidence of ovarian hyperstimulation syndrome(OHSS) between two groups were compared. There were no significant differences in age, body mass index (BMI), and other clinical data between two groups (P>0.05).

Results

①The comparison between two groups of patients infertility factors, the difference of male factor was statistically significant(χ2=10.322, P<0.05). There were no statistically significant difference between two groups in age, BMI, duration of infertility, infertility type, causes of infertility in endometriosis, polycystic ovary syndrome (PCOS), unexplained infertility, etc. (P>0.05). ②The difference in number of Gn days [(9.4±1.7) d vs (9.8±2.2) d], Gn dosage [(1 883.5±532.3) U vs (2 277.1±694.2) U], the number of oocytes [(12.3±6.1) vs (10.1±5.4)], the number of high-quality eggs [(9.1±5.2) vs (7.8±4.9)], the incidence of adverse outcomes (9.1% vs 25.1%), progesterone level of hCG day [(3.7±2.1) U / L vs (2.8±1.6) U / L], live birth rate (69.7% vs 50.0%) between two groups were statistically significant (χ2=2.154, 6.227, 3.564, 2.373, 20.187, 3.488, 0.033; P<0.05).

Conclusions

Using rFSH, the total dose of Gn is less required and period to stimulate is short, it also improvs the quantity and quality of oocytes, at the same time, it can reduce the rate of adverse outcomes, and get high live birth rate.

表1 两组患者一般情况比较(±s)
表2 两组不良周期结局比较[个(%)]
表3 两组促排卵情况比较(±s)
表4 两组临床结局比较[个(%)]
[1]
Al-Inany H, Aboulghar M, Mansour R, et al. Meta-analysis of recombinant versus urinary-derived FSH: an update[J]. Hum Reprod, 2003, 18(2):305-313.
[2]
蒋元华,段金良.丽申宝与果纳芬在IVF-ET长方案的临床比较[J].中国性科学,2013, 22(1):29-31.
[3]
张娟,方小玲,谭小军,等. 果那芬和丽申宝在超促排卵治疗中的疗效比较[J].生殖医学杂志,2013, 22(1):62-64.
[4]
Fulghesu AM, Apa R, Belosi C, et al. Recombinant versus urinary follicle-stimulating hormone in the low-dose regimen in anovulatory patients with polycystic ovary syndrome: a safer and more effective treatment[J]. Horm Res, 2001, 55(5):224-228.
[5]
Streda R, Koryntová D, Mardesic T, et al. Clinical effects of recombinant versus urinary gonadotropins in ovulation induction [J]. Ceska Gynekol, 2011, 76(2):108-113.
[6]
Hugues JN, Bry-Gauillard H, Bständig B, et al. Comparison of recombinant and urinary follicle-stimulating hormone preparations in short-term gonadotropin releasing hormone agonist protocol for in vitro fertilization-embryotransfer [J]. J Assist Reprod Genet, 2001, 18(4):191-196.
[7]
Loumaye E, Dreano M, Galazka, et al. Recombinant follicle stimulating hormone: development of the first biotechnology product for the treatment of infertility [J]. Hum Reprod Update, 1998, 4:862-881.
[8]
Daya S, Ledger W, Auray JP, et al. Cost-effectiveness modelling of recombinant FSH versus urinary FSH in assisted reproduction techniques in the UK [J]. Hum Reprod, 2001, 16(12):2563-2569.
[9]
Balasch J, Barri PN. Reflections on the cost-effectiveness of recombinant FSH in assisted reproduction. The clinician's perspective [J]. J Assist Reprod Genet, 2001, 18(2):45-55.
[10]
Sunkara SK, Rittenberg V, Raine-Fenning N, et al. Association between the number of eggs and live birth in IVF treatment: an analysis of 400 135 treatment cycles[J]. Hum Reprod, 2011, 26(7):1768-1774.
[11]
Stoop D, Ermini B, Polyzos NP, et al. Reproductive potential of a metaphase Ⅱ oocyte retrieved after ovarian stimulation: an analysis of 23 354 ICSI cycles [J]. Hum Reprod, 2012, 27(7):2030-2035.
[12]
Macklon NS, Fauser BC. Mild stimulation in in vitro fertilization [J]. Ann NY Acad Sci, 2003, 997:105-111.
[13]
Pellicer A, Ballester MJ. Aetiological factors involved in the low response to gonadotrophins in infertile women with normal basal serum follicle stimulating hormone levels [J]. Hum Reprod, 1994, 9(5):806-811.
[14]
Liu X, Hao C, Wang J. Efficacy of highly purified urinary FSH versus recombinant FSH in chinese women over 37 years undergoing assisted reproductive techniques [J]. Int J Fertil Steril, 2015, 8(4):385-392.
[15]
Mochtar MH, Van der Veen, Ziech M, et al. Recombinant luteinizing hormone (rLH) for controlled ovarian hyperstimulation in assisted reproductive cycles [J]. Cochrane Database Syst Rev, 2007, 18(2):CD005070-CD005070.
[16]
Matorras R, Prieto B, Exposito A, et al. Mid-follicular LH supplementation in women aged 35-39 years undergoing ICSI cycles: a randomized controlled study [J]. Reprod Biomed Online, 2009, 19(6):879-887.
[17]
Hillier SG. Paracrine support of ovarian stimulation [J]. Mol Hum Reprod, 2009, 15(12):843-850.
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