Chinese Medical E-ournals Database

Chinese Journal of Obstetrics & Gynecology and Pediatrics(Electronic Edition) ›› 2015, Vol. 11 ›› Issue (05): 584 -588. doi: 10.3877/cma.j.issn.1673-5250.2015.05.007

Special Issue:

Original Article

Comparison of clinical outcomes of controlled ovarian stimulation with different gonadotropin

Xiaman Huang1, Fangle Gu1, Fang Lyu1, Yu Pan1, Xiaomei Zhang1()   

  1. 1. Reproductive Medicine Center of Clinical Medical School of Yangzhou University, Yangzhou 225001, Jiangsu Province, China
  • Received:2015-06-12 Revised:2015-08-09 Published:2015-10-01
  • Corresponding author: Xiaomei Zhang
  • About author:
    Corresponding author: Zhang Xiaomei, Email:
Objective

To investigate differences in clinical outcomes of ovulation by different gonadotropin (Gn), including recombinant human follicle stimulating hormone (rFSH) and urinary FSH (uFSH).

Methods

A total of 396 cases of patients undergoing in vitro fertilization/intra-cytoplasmic sperm injection and embryo transfer (IVF/ICSI-ET)in Reproductive Medicine Center of Clinical Medical School of Yangzhou University from January 2011 to December 2013, a total of 428 cycles were collected as the research object. According to different types of Gn, the patient were divided into rFSH group (253 cycles) and uFSH group (175 cycles). General data, Gn dosage, number of Gn days, number of oocytes, the number of high-quality eggs, implantation rate, the incidence of adverse outcomes, pregnancy, live birth rate, abortion rate, multiple pregnancies and the incidence of ovarian hyperstimulation syndrome(OHSS) between two groups were compared. There were no significant differences in age, body mass index (BMI), and other clinical data between two groups (P>0.05).

Results

①The comparison between two groups of patients infertility factors, the difference of male factor was statistically significant(χ2=10.322, P<0.05). There were no statistically significant difference between two groups in age, BMI, duration of infertility, infertility type, causes of infertility in endometriosis, polycystic ovary syndrome (PCOS), unexplained infertility, etc. (P>0.05). ②The difference in number of Gn days [(9.4±1.7) d vs (9.8±2.2) d], Gn dosage [(1 883.5±532.3) U vs (2 277.1±694.2) U], the number of oocytes [(12.3±6.1) vs (10.1±5.4)], the number of high-quality eggs [(9.1±5.2) vs (7.8±4.9)], the incidence of adverse outcomes (9.1% vs 25.1%), progesterone level of hCG day [(3.7±2.1) U / L vs (2.8±1.6) U / L], live birth rate (69.7% vs 50.0%) between two groups were statistically significant (χ2=2.154, 6.227, 3.564, 2.373, 20.187, 3.488, 0.033; P<0.05).

Conclusions

Using rFSH, the total dose of Gn is less required and period to stimulate is short, it also improvs the quantity and quality of oocytes, at the same time, it can reduce the rate of adverse outcomes, and get high live birth rate.

表1 两组患者一般情况比较(±s)
表2 两组不良周期结局比较[个(%)]
表3 两组促排卵情况比较(±s)
表4 两组临床结局比较[个(%)]
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