Chinese Medical E-ournals Database

Chinese Journal of Obstetrics & Gynecology and Pediatrics(Electronic Edition) ›› 2015, Vol. 11 ›› Issue (4): 539 -542. doi: 10.3877/cma.j.issn.1673-5250.2015.04.022

Special Issue:

Review

Research progress of relationship between helper T cell 17/regulatory T cell immune imbalance and pre-eclampsia

Yuzhen Xie, Qing He, Fang He, Yingtao Li*()   

  1. Department of Gynecology, Third Affiliated Hospital of Guangzhou Medical University, Guangzhou 510150, Guangdong Province, China
  • Received:2015-01-08 Revised:2015-06-19 Published:2015-08-01
  • Corresponding author: Yingtao Li

Pre-eclampsia (PE) is a common obstetric syndrome affecting about 9.4% of pregnant women in our country. The etiology and pathogenesis of PE are not fully understood. Some literatures found that the onset of PE was an imbalance of maternal-fetal immune tolerance. Maternal immune system can not recognize the fetal alloantigen and the activation of cell-mediated immunity which may play a role in the etiology of PE. PE has an immune imbalance of helper T cell (Th)1/Th2. Recent data suggest that PE is a Th17/regulatory T cell (Treg) immune imbalance with a predominance of Th17 immunity. The latest research progress about relationship between Th17/Treg immune imbalance and PE will be reviewed.

图1 PE患者Th17/Treg免疫失衡机制示意图
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