Analysis of dynamic monitoring of serum bilirubin in premature infants with glucose 6 phosphate dehydrogenase deficiency

doi:10.3877/cma.j.issn.1673-5250.2015.04.015

Objective

To investigate the characteristics of bilirubin dynamic changes in premature infants with glucose 6 phosphate dehydrogenase(G6PD) deficiency.

Methods

From January 2013 to December 2013, a total of 40 premature infants with G6PD deficiency were included into the study as G6PD deficiency in the same hospital group(n=40). Meanwhile 42 premature infants without G6PD deficiency who were admitted into the same hospital were chosen as normal control group(n=42). Serum bilirubin were monitored using percutaneous bilirubin measurement instrument at 24, 48, 72, 96, 120, 144, 168 h after birth, and the levels of serum bilirubin and the incidence rate of hyper bilirubinemia were compared between two groups.

Results

The incidence rate of hyperbilirubinemia in the G6PD deficiency group was significantly higher than that of normal control group(45.0% vs 14.3%), and the difference was significant(χ²=9.336 0, P<0.01). There was no significant difference between two groups in the serum bilirubin level at 24 h after birth(t=0.471 6, P>0.05). The serum bilirubin levels of G6PD deficiency group were significantly higher than those of normal control group at 48, 72, 96, 120, 144, 168 h after birth, and the differences between two groups had statistical significance(t=3.767 5, 2.618 3, 2.511 3, 2.542 3, 3.031 1, 2.869 9; P<0.01).

Conclusion

The serum bilirubin levels of premature infants with G6PD deficiency was prone to high bilirubinemia sickness.

Key words: Glucose 6 phosphate dehydrogenase, Bilirubin, Premature infants

表1 两组患儿的一般临床资料比较(±s)

组别	例数	胎龄(孕周)	出生体质量(g)	性别[例数(%)]		1 min Apgar评分(分)
组别	例数	胎龄(孕周)	出生体质量(g)	男性	女性	1 min Apgar评分(分)
G6PD缺乏组	40	33.4±1.4	1 710±190	22(55.0)	18(45.0)	6.9±2.0
正常对照组	42	33.8±1.1	1 720±196	26(61.9)	16(38.1)	7.1±2.1
t值/χ²值		1.433 8	0.234 6	0.402 4		0.441 7
P值		>0.05	>0.05	>0.05		>0.05

表1 两组患儿的一般临床资料比较(±s)

组别	例数	胎龄(孕周)	出生体质量(g)	性别[例数(%)]		1 min Apgar评分(分)
组别	例数	胎龄(孕周)	出生体质量(g)	男性	女性	1 min Apgar评分(分)
G6PD缺乏组	40	33.4±1.4	1 710±190	22(55.0)	18(45.0)	6.9±2.0
正常对照组	42	33.8±1.1	1 720±196	26(61.9)	16(38.1)	7.1±2.1
t值/χ²值		1.433 8	0.234 6	0.402 4		0.441 7
P值		>0.05	>0.05	>0.05		>0.05

表2 两组早产儿血清胆红素监测结果比较(±s，μmol/L)

组别	例数	血清胆红素水平
组别	例数	生后24 h	生后48 h	生后72 h	生后96 h	生后120 h	生后144 h	生后168 h
G6PD缺乏组	40	84±50	176±71	203±91	224±88	208±75	195±64	180±52
正常对照组	42	79±46	125±46	150±77	172±72	168±58	152±45	146±38
t值		0.471 6	3.767 5	2.618 3	2.511 3	2.542 3	3.031 1	2.869 9
P值		>0.05	<0.01	<0.01	<0.01	<0.01	<0.01	<0.01

表2 两组早产儿血清胆红素监测结果比较(±s，μmol/L)

组别	例数	血清胆红素水平
组别	例数	生后24 h	生后48 h	生后72 h	生后96 h	生后120 h	生后144 h	生后168 h
G6PD缺乏组	40	84±50	176±71	203±91	224±88	208±75	195±64	180±52
正常对照组	42	79±46	125±46	150±77	172±72	168±58	152±45	146±38
t值		0.471 6	3.767 5	2.618 3	2.511 3	2.542 3	3.031 1	2.869 9
P值		>0.05	<0.01	<0.01	<0.01	<0.01	<0.01	<0.01

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