Research status of early monitoring of brain injury caused by neonatal hyperbilirubinemia

doi:10.3877/cma.j.issn.1673-5250.2021.06.003

brain injury caused by Although neonatal hyperbilirubinemia (NHB) is the most common complication of NHB. Some children with brain injury caused by NHB have hidden clinical manifestations, lack of specificity, and are prone to missed diagnosis and delayed treatment, thus resulting in irreversible neurological sequelae.Currently, the diagnosis of brain injury caused by NHB is mainly combined with clinical manifestations, brain MRI and brain stem auditory evoked potential and other auxiliary examinations. In recent years, early monitoring of brain function and detection of biochemical markers of brain injury, such as S100B protein and neuron-specific enolase (NSE) have been advocated for brain injury caused by high-risk NHB. At the same time, combined with neurobehavioral score, bilirubin-induced neurological dysfunction (BIND) score and neonatal behavioral neurological assessment (NBNA) score, children at high risk of brain injury caused by NHB have been evaluated. Molecular genetics detection, as an emerging monitoring technology for diagnosis of brain injury caused by NHB, has a broad development prospect. The clinical application value of magnetic resonancediffusion weighted imaging(DWI) and magnetic resonance spectroscopy (MRS) in brain injury caused by NHB still needs to be confirmed by researches.

Key words: Hyperbilirubinemia, neonatal, Brain injury, Kernicterus spectrum disorder, Neuroimaging, head, Early diagnosis, Biological markers, Infant, newborn

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