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中华妇幼临床医学杂志(电子版)

Chinese Journal of Obstetrics & Gynecology and Pediatrics(Electronic Edition) ›› 2014, Vol. 10 ›› Issue (02): 185 -188. doi: 10.3877/cma.j.issn.1673-5250.2014.02.013

Special Issue: ； ；

Original Article

Influences of Plasma Tumor Necrosis Factor-α, Interleukin-8 and Vascular Endothelial Growth Factor Levels of Neonates with Meconium Aspiration Syndrome Treated by Proportional Assist Ventilation

Rong Wu1, Guofang Zheng1, Hongli Zhu1, Jinhui Hu1, Li Zha1, Yanguan Lyu1, Zhichun Feng2()   

  1. 1. Neonatal Medical Center, Huaian Maternity and Child Healthcare Hospital Affiliated to Yangzhou University Medical Academy, Huaian 223002, Jiangsu Province, China
  • Received:2013-10-15 Revised:2014-01-21 Published:2014-04-01
  • Corresponding author: Zhichun Feng
  • About author:
    (Corresponding author: Feng Zhichun, Email: )
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Objective

To investigate influences of tumor necrosis factor-α(TNF-α) , interleukin-8(IL-8) and vascular endothelial growth factor(VEGF) of neonates with meconium aspiration syndrome(MAS) treated by proportional assist ventilation (PAV) .

Methods

From January 2011 to October 2013, a total of 30 neonates with MAS who required mechanical ventilation were recruited into this study．They were divided randomly into two groups according to different ventilation modes PAV group (n=15, supported by PAV mode) and synchronized intermittent mandatory ventilation (SIMV) group (n =15, supported by SIMV mode) ．There had no significant differences between two groups on age, gestation age, birth weight, and so on (P>0.05) ．At the same time, another 10 healthy term infants were selected as control group．The plasma TNF-α, IL-8 and VEGF levels of neonates in three groups were measured by enzyme linked immunosorbent assay at the first day and third day after birth．The study protocol was approved by the Ethical Review Board of Investigation in Huaian Maternity and Child Healthcare Hospital Affiliated to Yangzhou University Medical Academy．Informed consent was obtained from all participates' parents.

Results

There had no statistically significant differences of TNF-α levels among three groups at first day and third day [(1 395.80 ± 426.46) ng/ L vs．(1 428.27 ± 414.24) ng/ L vs．(374.30 ± 229.91) ng/ L; (1 356.87 ± 315.54) ng/ L vs．(1 602.13 ± 371.10) ng/ L vs．(383.30 ± 187.00) ng/ L; F=27.573, 48.142, P=0.000], there also had statistically significant differences of IL-8 levels among three groups at first day and third day [(2.231 ± 1.063) μg/ L vs．(2.409 ± 1.058) μg/ L vs．(0.398 ± 0.214) μg/ L; (1.813 ± 0.701) μg/L vs．(2.484 ± 1.049) μg/ L vs．(0.409 ± 0.231) μg/ L; F=216.198, 21.173, P= 0.000], and there had no statistically significant differences of VEGF levels among three groups at first day and third day [(167.07 ± 77.23) ng/ L vs．(179.93 ± 78.83) ng/ L vs．(41.90 ± 13.51) ng/ L; (141.73 ± 52.69) ng/ L vs．(186.27 ± 68.25) ng/ L vs．(39.10 ± 10.14) ng/ L; F=14.092, 22.987, P=0.000].

Conclusions

In case to maintain normal oxygen saturation and blood gas, PAV mode can reduce the incidence rate of ventilation-induced lung injury than that of SIMV mode.

Key words: Tumor necrosis factor-alpha, Interleukin-8, Vascular endothelial growth factor, Interactive ventilatory support, Meconium aspiration syndrome, Infant, newborn
表1 3组血浆TNF-α水平在不同时间点的比较（ng／L，±s）
Table 1 Comparison of plasma TNF-α levels at different time points among three groups （ng／L，±s）
组别 n 生后1 d 生后3 d t P
PAV组 15 1 395.80 ± 426.46ab 1 356.87 ± 315.54ac 0.284 0.778
SIMV组 15 1 428.27±414.24a 1 602.13±371.10a -1.208 0.237
对照组 10 374.30 ± 229.91 383.30±187.00 －0.096 0.925
F 　 27.573 48.142 　 　
P 　 0.000 0.000 　 　
表2 3组血浆IL-8水平在不同时间点的比较（μg／L，±s）
Table 2 Comparison of plasma IL-8 levels at different time points among three groups （μg／L，±s）
组别 n 生后1 d 生后3 d t P
PAV组 15 2.231±1.063ab 1.813±0.701ac 1.357 0.186
SIMV组 15 2.409 ± 1.058a 2.484±1.049a -0.196 0.846
对照组 10 0.398±0.214 0.409 ± 0.231 -0.111 0.913
F 　 16.198 21.173 　 　
P 　 0.000 0.000 　 　
表3 3组血浆VEGF水平在不同时间点的比较（ng／L，±s）
Table 3 Comparison of plasma VEGF levels at different time points among three groups(ng／L，±s）
组别 n 生后1 d 生后3 d t P
PAV组 15 167.07 ± 77.23ab 141.73±52.69ac 1.049 0.303
SIMV组 15 179.93±78.83a 186.27±68.25a -0.235 0.816
对照组 10 41.90±13.51 9.10±10.14 0.524 0.607
F 　 14.092 22.987 　 　
P 　 0.000 0.000 　 　
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