Investigation of Allergic Reactions to Common Aeroallergens by Skin Prick Tests in Children With Henoch-Schonlein Purpura

doi:10.3877/cma.j.issn.1673-5250.2013.06.010

Chinese Journal of Obstetrics & Gynecology and Pediatrics(Electronic Edition) ›› 2013, Vol. 09 ›› Issue (06): 761 -763. doi: 10.3877/cma.j.issn.1673-5250.2013.06.010

Special Issue: ；

Original Article

Investigation of Allergic Reactions to Common Aeroallergens by Skin Prick Tests in Children With Henoch-Schonlein Purpura

Li-na CHEN¹, Gui-chao LAN¹, Ba-cuo-zhen QIANG¹, De-yuan LI¹, Lin ZHONG¹, Li QIU¹, Han-min LIU¹()

^1. Department of Pediatrics, West China Second University Hospital, Sichuan University , Chengdu 610041, Sichuan Province , China

Received:2013-08-19 Revised:2013-11-25 Published:2013-12-01
Corresponding author: Han-min LIU
About author:
(Corresponding author : LIU Han-min,Email : myuxuan@ 163. net)

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Objective

To analyze the allergic reactions to common inhalant allergens in children with Henoch-Schonlein purpura (HSP) , hoping to identify new diagnostic and therapeutic targets in HSP.

Methods

A total of 110 children with HSP from February 2011 to May 2012 in our hospital underwent skin prick tests with 13 common aeroallergens using allergen extracts obtained from ALK-ABELLO company (Horsholm, Denmark). The study protocol was approved by the Ethical Review Board of Investigation in Human Beings of West China Second University Hospital,Sichuan University. Informed consent was obtained from the parents of each participating patient.

Results

A total of 107 children presented with positive reactions to tested allergens (97.3%). dermatophagoides farinae,dermatophagoides pteronyssinus and periplaneta americana were manifested with the highest positive rates (93. 6 %, 79. 1 % and 63. 6 % , respectively). Of the 101 children had allergic reactions to no less than 3 aeroallergens (91.8%). The positive rates of dermatophagoides pteronyssinus,tropical mites, dog, mugwort and mixed mould I were significantly different among male and female HSP children (P<0. 05). But there was no correlation between the positive aeroallergens and HSP nephritis.

Conclusions

Most HSP children had positive skin reactions to common aeroallergens. It might be beneficial in the treatment of HSP by reducing exposure to aeroallergens.

Key words: allergens, skin prick test, purpura, Schoenlein-Henoch

表1 HSP患儿SPT结果

Table 1 Results of SPT in HSP children

过敏原数量（种）	人数(n)	构成比(％)
0	3	2. 7
1	0	0. 0
2	6	5. 5
3	14	12. 7
4	27	24. 6
5	28	25. 4
6	20	18. 2
7	12	10. 9
合计	110	100. 0

表1 HSP患儿SPT结果

Table 1 Results of SPT in HSP children

过敏原数量（种）	人数(n)	构成比(％)
0	3	2. 7
1	0	0. 0
2	6	5. 5
3	14	12. 7
4	27	24. 6
5	28	25. 4
6	20	18. 2
7	12	10. 9
合计	110	100. 0

表2 不同过敏原阳性率及反应强度比较[n(%)]

Table 2 Comparison of positive rates and response intensity among different aeroallergens[n (%)]

过敏原种类	阳性程度			合计
过敏原种类	1+	2 +	≥3 +	合计
粉尘螨	17(15.5)	63(57. 3)	23(20.9)	103(93. 6)
屋尘螨	60(54. 5)	21(19.1)	6 (5.5)	87(79. 1)
美洲大蠊	37(33. 6)	32(29. 1)	1 (0. 9)	70(63. 6)
德国小蠊	39(35. 5)	23(20. 9)	2 (1.8)	64(58. 2)
花粉Ⅱ	35(31. 8)	1 (0. 9)	0 (0.0)	36(32.7)
狗	29(26.4)	2 (1.8)	0 (0.0)	31(28.2)
热带螨	21(19.1)	4 (3. 6)	3 (2.7)	28(25. 5)
花粉I	23(20. 9)	4 (3. 6)	0 (0.0)	27(24. 6)
艾蒿	21(19.1)	2 (1.8)	0 (0.0)	23(20.9)
猫	11(10. 0)	0 (0.0)	1 (0. 9)	12(10. 9)
霉菌I	10 (9. 1)	2 (1.8)	0 (0.0)	12(10. 9)
豚草	4 (3.6)	0 (0.0)	0 (0.0)	4 (3. 6)
霉菌 Ⅳ	2 (1.8)	0 (0.0)	0 (0.0)	2 (1. 8)

表2 不同过敏原阳性率及反应强度比较[n(%)]

Table 2 Comparison of positive rates and response intensity among different aeroallergens[n (%)]

过敏原种类	阳性程度			合计
过敏原种类	1+	2 +	≥3 +	合计
粉尘螨	17(15.5)	63(57. 3)	23(20.9)	103(93. 6)
屋尘螨	60(54. 5)	21(19.1)	6 (5.5)	87(79. 1)
美洲大蠊	37(33. 6)	32(29. 1)	1 (0. 9)	70(63. 6)
德国小蠊	39(35. 5)	23(20. 9)	2 (1.8)	64(58. 2)
花粉Ⅱ	35(31. 8)	1 (0. 9)	0 (0.0)	36(32.7)
狗	29(26.4)	2 (1.8)	0 (0.0)	31(28.2)
热带螨	21(19.1)	4 (3. 6)	3 (2.7)	28(25. 5)
花粉I	23(20. 9)	4 (3. 6)	0 (0.0)	27(24. 6)
艾蒿	21(19.1)	2 (1.8)	0 (0.0)	23(20.9)
猫	11(10. 0)	0 (0.0)	1 (0. 9)	12(10. 9)
霉菌I	10 (9. 1)	2 (1.8)	0 (0.0)	12(10. 9)
豚草	4 (3.6)	0 (0.0)	0 (0.0)	4 (3. 6)
霉菌 Ⅳ	2 (1.8)	0 (0.0)	0 (0.0)	2 (1. 8)

图1 吸入物过敏原阳性率的性别差异。（男性vs女性，P<0.05。）

Figure 1 Sex differences among aeroallergens. (male vs female, P<0. 05.)

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