Chinese Medical E-ournals Database

Chinese Journal of Obstetrics & Gynecology and Pediatrics(Electronic Edition) ›› 2013, Vol. 09 ›› Issue (02): 250 -253. doi: 10.3877/cma.j.issn.1673-5250.2013.02.035

Special Issue:

Review

Research Progress of Multi-organ Dysfunction After Neonatal Asphyxia

Ying LI1(), Si-guo SHEN1   

  1. 1. Department of Pediatrics, First People's Hospital of Xiaogan, Xiaogan 432000, Hubei Province, China
  • Received:2013-01-05 Revised:2013-03-19 Published:2013-04-01
  • Corresponding author: Ying LI
  • About author:
    (Corresponding author: LI Ying, Email: )

Multi-organ dysfunction after neonatal asphyxia is one of the important causes of neonatal death. Timely detection of organ dysfunction and intervention can reduce damage and promote recovery. Recent studies show that the application of ultrasonography and biological markers contribute to the clinical diagnosis and prediction of outcomes. This article focuses on the research progress of multi-organ dysfunction after neonatal asphyxia.

[1]
Committee on Fetus and Newborn, American Academy of Pediatrics, and Committee on Obstetric Practice, American College of Obstetricians and Gynecologists. Use and abuse of the Apgar score[J]. Pediatrics, 1996, 98(1):141-142.
[2]
Zhu XY, Zhang QS. New understanding of the diagnosis of neonatal asphyxia[J]. Chin J Neonatol, 2011, 26(4):217-220.
[3]
Ilves P, Lintrop M, Talvik I, et al. Changes in cerebral and visceral blood flow velocities in asphyxiated term neonates with hypoxic-ischemic encephalopathy[J]. J Ultrasound Med, 2009, 28(11):1471-1480.
[4]
Julkunen MK, Uotila J, Eriksson K, et al. Obstetric parameters and Doppler findings in cerebral circulation as predictors of 1 year neurodevelopmental outcome in asphyxiated infants[J]. J Perinatol, 2012, 32(8):631-638.
[5]
Ilves P, Lintrop M, Talvik I, et al. Low cerebral blood flow velocity and head circumference in infants with severe hypoxic ischemic encephalopathy and poor outcome[J]. Acta Paediatr, 2009, 98(3):459-465.
[6]
Gazzolo D, Marinoni E, Giovannini L, et al. Circulating adrenomedullin is increased in preterm newborns developing intraventricular hemorrhage[J]. Pediatr Res, 2001, 50(4):544-547.
[7]
Di Iorio R, Marinoni E, Lituania M, et al. Adrenomedullin increases in term asphyxiated newborns developing intraventricular hemorrhage[J]. Clin Biochem, 37(12):1112-1116.
[8]
An L, Zhu WW, Wang P, et al. Protective effects and mechanism of activin in neonatal rats with hypoxic ischemic brain damage[J].Chin J Pediatr, 2005, 43(6):465-466.
[9]
Florio P, Frigiola A, Battista R, et al. Activin A in asphyxiated full-term newborns with hypoxic ischemic encephalopathy[J]. Front Biosci: Elite Ed, 2010, 2:36-42.
[10]
Florio P, Perrone S, Luisi S, et al.Increased plasma concentrations of activin a predict intraventricular hemorrhage in preterm newborns[J]. Clin Chem, 2006, 52(8):1516-1521.
[11]
Florio P, Luisi S, Moataza B, et al.High urinary concentrations of activin A in asphyxiated full-term newborns with moderate or severe hypoxic ischemic encephalopathy[J].Clin Chem, 2007, 53(3):520-522.
[12]
Florio P, Luisi S, Bruschettini M, et al. Cerebrospinal fluid activin a measurement in asphyxiated full-term newborns predicts hypoxic ischemic encephalopathy[J].Clin Chem, 2004, 50(12):2386-2389.
[13]
Ennen CS, Huisman TA, Savage WJ, et al.Glial fibrillary acidic protein as a biomarker for neonatal hypoxic-ischemic encephalopathy treated with whole-body cooling[J].Am J Obstet Gynecol, 2011, 205(3):251.e1-251.e7.
[14]
Wei Y, Xu J, Xu T, et al.Left ventricular systolic function of newborns with asphyxia evaluated by tissue Doppler imaging[J].Pediatr Cardiol, 2009, 30(6):741-746.
[15]
Wei Y, Xu T, Xu JX, et al. Evaluation of cardiac function after neonatal asphyxia by Doppler tissue imaging[J].Chin Med J, 2009, 89(2):117-120.
[16]
Matter M, Abdel-Hady H, Attia G, et al.Myocardial performance in asphyxiated full-term infants assessed by Doppler tissue imaging[J].Pediatr Cardiol, 2010, 31(5):634-642.
[17]
Correale M, Nunno L, Ieva R, et al.Troponin in newborns and pediatric patients[J]. Cardiovasc Hematol Agents Med Chem, 2009, 7(4):270-278.
[18]
Thygesen K, Alpert JS, White HD, et al.Universal definition of myocardial infarction[J]. J Am Coll Cardiol, 2007, 50(22):2173-2195.
[19]
Singh V, Martinezclark P, Pascual M, et al. Cardiac biomarkers - the old and the new: A review[J]. Coron Artery Dis, 2010, 21(4):244-256.
[20]
Gaze DC, Collinson PO.Cardiac troponin Ⅰ should be interpreted with caution in paediatric neonatal patients[J].Biol Neonate, 2005, 87(1):19.
[21]
Szymankiewicz M, Matuszczak-Wleklak M, Hodgman JE, et al. Usefulness of cardiac troponin T and echocardiography in the diagnosis of hypoxic myocardial injury of full-term neonates[J]. Biol Neonat, 2005, 88(1):19-23.
[22]
Boo NY, Hafidz H, Nawawi HM, et al.Comparison of serum cardiac troponin T and creatine kinase MB isoenzyme mass concentrations in asphyxiated term infants during the first 48 h of life[J]. J Paediatr Child Health, 2005, 41(7):331-337.
[23]
Martín-Ancel A, García-Alix A, Gayá F, et al. Multiple organ involvement in perinatal asphyxia[J]. J Pediatr, 1995, 127(5):786-793.
[24]
Lapointe A, Barrington KJ. Pulmonary hypertension and the asphyxiated newborn[J]. J Pediatr, 2011, 158(2 Suppl):e19-24.
[25]
Liu J, Feng ZC. Changes in pulmonary arterial pressure in term-infants with hypoxic-ischemic encephalopathy[J]. Pediatr Int, 1999, 51(6):786-789.
[26]
Ban R, Ogihara T, Mori Y, et al. Meconium aspiration delays normal decline of pulmonary vascular resistance shortly after birth through lung parenchymal injury[J]. Neonatology, 2011, 99(4):272-279.
[27]
Mortazavi F, Hosseinpour H, Sakha S, et al. Acute kidney failure in neonatal period[J]. Iran J Kidney Dis, 2009, 3(3):136-140.
[28]
Luciano R, Gallini F, Romagnoli C, et al. Doppler evaluation of renal blood flow velocity as a predictive index of acute renal failure in perinatal asphyxia[J]. Eur J Pediatr, 1998, 157(8):656-660.
[29]
Mohd, Ashraf, Ahmed N, Chowdhary J, et al. Acute renal failure: Nephrosonographic findings in asphyxiated neonates[J]. Saudi J Kidney Dis Transpl, 2011, 22(6):1187-1192.
[30]
Sarafidis K, Tsepkentzi E, Agakidou E, et al. Serum and urine acute kidney injury biomarkers in asphyxiated neonates[J]. Pediatr Nephrol, 2012, 27(9):1575-1582.
[31]
Willis F, Summers J, Minutillo C, et al. Indices of renal tubular function in perinatal asphyxia[J]. Arch Dis Child Fetal Neonatal Ed, 1997, 77(1):F57-60.
[32]
Askenazi D. Are we ready for the clinical use of novel acute kidney injury biomarkers[J]? Pediatr Nephrol, 2012, 27(9):1423-1425.
[33]
Askenazi DJ, Ambalavanan N, Goldstein SL. Acute kidney injury in critically ill newborns: What do we know? What do we need to learn[J]? Pediatr Nephrol, 2009, 24(2):265-274.
[34]
Barnett CP, Perlman M, Ekert PG. Clinicopathological correlations in postasphyxial organ damage: A donor organ perspective[J]. Pediatrics, 1997, 99(6):797-799.
[35]
Ikeda T, Murata Y, Quilligan EJ, et al. Histologic and biochemical study of the brain, heart, kidney, and liver in asphyxia caused by occlusion of the umbilical cord in near-term fetal lambs[J]. Am J Obstet Gynecol, 2000, 182(2):449-457.
[36]
Tarcan A, Tiker F, Güvenir H, et al. Hepatic involvement in perinatal asphyxia[J]. J Matern Fetal Neonatal Med, 2007, 20(5):407-410.
[37]
Young CM, Kingma SD, Neu J. Ischemia-reperfusion and neonatal intestinal injury[J]. J Pediatr, 2011, 158(2 Suppl):e25-28.
[38]
Aydemir C, Dilli D, Oguz SS, et al. Serum intestinal fatty acid binding protein level for early diagnosis and prediction of severity of necrotizing enterocolitis[J]. Early Hum Dev, 2011, 87(10):659-661.
[39]
Thuijls G, Derikx JP, van Wijck K, et al. Non-invasive markers for early diagnosis and determination of the severity of necrotizing enterocolitis[J]. Ann Surg, 2010, 251(6):1174-1180.
[40]
Chen DM, Lei GF, Peng WL.Value of serum cytosolic β-glucosidase in diagnosis of neonatal necrotizing enterocolitis[J]. Chin J Pediatr, 2011, 49(5):367-370.
[41]
Aydemir O, Aydemir C, Sarikabadayi YU, et al. Fetal calprotectin levels are increased in infants with necrotizing enterocolitis[J]. J Matern Fetal Neonatal Med, 2012, 25(11):2237-2241.
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