Curative Effects of Low Molecular Weight Heparin and Salvia Miltiorrhiza on Early Onset Severe Preeclampsia

doi:10.3877/cma.j.issn.1673-5250.2012.05.022

Objective

To analysis the curative effects of low molecular weight heparin and salvia miltiorrhiza on early onset severe preeclampsia.

Methods

From June 2010 to December 2011, 75 women with early onset severe preeclampsia were included in the study, and divided into group A(n=18, routine treatment), group B(n=20, routine treatment + low molecular weight heparin), group C(n=19, routine treatment + salvia)and group D(n=18, routine treatment+ low molecular weight heparin+ salvia). The study protocol was approved by the Ethical Review Board of Investigation in Human Being of Chongqing Three Gorges Central Hospital.Informed consent was obtained from each patients.

Results

There were significant differences in the postpartum 7 d hospital discharge rate, incidence of elevated liver enzymes and hypoproteinemia between group A and the other groups(P<0.05). The prolong average gestational age and birth weight in group D was obviously higher than that of the other groups.

Conclusions

Low molecular weight heparin combined with salvia on early onset severe preeclampsia contributes to the improvement of materno-fetal outcomes.

Key words: low molecular heparin, salvia, early onset of severe preeclampsia

表1 4组患者并发症发生情况比较[n(%)]

Table 1 Comparison of complications among four groups [n(%)]

组别	n	肺水肿	心力衰竭	脑出血	胎盘早剥	产后出血	转氨酶升高	低蛋白血症	视觉障碍
A组	18	2(11.11)	1(5.55)	0(0.00)	2(11.10)	3(16.67)	16(88.90)	17(94.44)	5(27.78)
B组	20	0 (0.00)	0(0.00)	0(0.00)	0 (0.00)	3(15.00)	12(60.00)	12(60.00)	4(20.00)
C组	19	0 (0.00)	0(0.00)	1(5.26)	0 (0.00)	2(10.53)	12(63.16)	10(52.63)	3(15.79)
D组	18	1 (5.55)	0(0.00)	0(0.00)	1 (5.55)	3(16.67)	10(55.56)	9(50.00)	3(16.67)

表1 4组患者并发症发生情况比较[n(%)]

Table 1 Comparison of complications among four groups [n(%)]

组别	n	肺水肿	心力衰竭	脑出血	胎盘早剥	产后出血	转氨酶升高	低蛋白血症	视觉障碍
A组	18	2(11.11)	1(5.55)	0(0.00)	2(11.10)	3(16.67)	16(88.90)	17(94.44)	5(27.78)
B组	20	0 (0.00)	0(0.00)	0(0.00)	0 (0.00)	3(15.00)	12(60.00)	12(60.00)	4(20.00)
C组	19	0 (0.00)	0(0.00)	1(5.26)	0 (0.00)	2(10.53)	12(63.16)	10(52.63)	3(15.79)
D组	18	1 (5.55)	0(0.00)	0(0.00)	1 (5.55)	3(16.67)	10(55.56)	9(50.00)	3(16.67)

表2 4组围生儿情况比较[n(%)]

Table 2 Comparison of perinatal infants outcome among four groups [n(%)]

组别	围生儿总数	胎儿窘迫	新生儿窒息	新生儿呼吸窘迫	平均延长胎龄(d)	平均出生体重(g)
A组	20	4(20.00)	12(60.00)	13(65.00)	4.7±2.1	2063.2±48.3
B组	22	1 (4.55)	8(36.36)	10(45.45)	5.8±3.4	2135.2±39.5
C组	21	2 (9.52)	6(28.57)	8(38.10)	6.2±3.6	2164.7±41.6
D组	21	1 (4.76)	7(33.33)	8(38.10)	10.3±4.5	2281.3±47.1

表2 4组围生儿情况比较[n(%)]

Table 2 Comparison of perinatal infants outcome among four groups [n(%)]

组别	围生儿总数	胎儿窘迫	新生儿窒息	新生儿呼吸窘迫	平均延长胎龄(d)	平均出生体重(g)
A组	20	4(20.00)	12(60.00)	13(65.00)	4.7±2.1	2063.2±48.3
B组	22	1 (4.55)	8(36.36)	10(45.45)	5.8±3.4	2135.2±39.5
C组	21	2 (9.52)	6(28.57)	8(38.10)	6.2±3.6	2164.7±41.6
D组	21	1 (4.76)	7(33.33)	8(38.10)	10.3±4.5	2281.3±47.1

[1]	Dekker GA.Preeclampsia and thrombophilia[J].Inherit Thrombophilia, 2003, 17(3):441-458.
[2]	Yue J, ed.Obstetrics and gynecology.7th ed[M].Beijing:People's Medical Publishing House, 2009, 92-101.
[3]	ACOG Committee on Practice. ACOG practice bulletin. Diagnosis and management of preeclampsia and eclampsia.Number 33, January 2002. American College of Obstetricians and Gynecologists[J]. Int J Gynaecol Obstet, 2002, 77(1):67-75.
[4]	Ling WW, Lin JH.Treatment options of early onset of severe preeclampsia[J].J Shanghai Jiaotong Univ: Med Sci, 2008, 28(3):336.
[5]	Hall DR, Odendaal HJ, Steyn DW.Expectant management of severe preeclampsia in the mid-trimester[J].Eur J Obstet Gynecol Reprod Biol, 2001, 96(2):168-172.
[6]	Lu LM, Hao YD, Chen Q, et al. Early onset of severe preeclampsia patients with gestational weeks for delivery on maternal and fetal outcomes effects[J]. Chin J Obstet Gynecol, 2010, 45(11):829.
[7]	Sarsam DS, Shamden M, Al Wazan R. Expectant versus aggressive management in severe preeclampsia remote from term[J].Singapore Med J, 2008, 49(9):698-703.
[8]	Xiong W, Zhou R.Preeclampsia anticoagulation treatment safety and effectiveness of evidence-based evaluation[J]. J Pract Obstet Gynecol, 2010, 26(9):27-29.
[9]	Vaisbueh E, Romero R, Mazaki-Tovi S, et al.Retinol binding protein 4-a novel association with early-onset pre-eclampsia[J].J Perinat Med, 2010, 38:129-139.
[10]	Tan JP, Guo ZJ, Wan B, et al. Effect of magnesium sulfate and low molecular weight heparin in the treatment of early onset preeclampsia clinical research[J].J Zhongshan Univ:Med Sci Ed, 2010, 31(5):67-71.
[11]	Yang YK, Lin JH, Lin QD.Low molecular weight heparin and Salvia miltiorrhiza in anticoagulant therapy of early onset severe preeclampsia a case of clinical research[J]. Prog Obstet Gynecol, 2010, 19(9):17-21.
[12]	Wei DH, Zhu XQ. Anticoagulant therapy and conventional methods of early onset severe preeclampsia patients[J].Matern Child Health Care China, 2010, 25(16):128-129.

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