To investigate the clinical effects of low molecular heparin calcium combined with salvia miltiorrhiza on early onset severe pre-eclampsia.

A total of 116 patients (aged 20-35 years) with early onset severe pre-eclampsia at 26-34 weeks of gestational age were divided into four group by their own will, group A (n=26, magnesium sulfate+ low molecular heparin calcium+ salvia miltiorrhiza) , group B (n =28, magnesium sulfate + low molecular heparin calcium) , group C (n =30, magnesium sulfate+ salvia miltiorrhiza) , group D (n=32, magnesium sulfate conventional treatment only) . There were no significant differences among four groups about age, gestational age, body weight index, gravidity, parity as well as degrees of retinopathy. The study protocol was approved by the Ethical Review Board of Investigation in Children Hospital of Hebei Province. Informed consent was obtained from all participates. Improvement of symptoms, edema disappeared, mean arterial pressure (MAP) , 24 hours urinary protein excretion, postpartum bleeding, prothrombin time (PT) , activated partial thromboplastin time (APTT) , fibrinogen (Fg) , D-dimer (DD) , triglyceride(TG) , total cholesterol (TC) , high density lipoprotein cholesterol (HDL-C) , low density lipoprotein cholesterol (LDL-C) , apolipoprotein (apo) A, apoB, incidence rate of retinopathy, and complications were analyzed statistically among four groups.

The symptoms improved rate of group A was higher than that of group D [92.31% (24/ 26) vs． 65.63%(21/ 32)], with significant difference (χ²=4.438 7, P<0.05) , but there were no significant differences between group A and group B, group A and group C (χ² =0.388 5, 0.384 9; P =0.50) ．Compared with group A, the edema disappeared rate of group B and group D were lower with statistically significant difference (χ² =2.230 0, 4.346 7; P<0.05) ．The level of MAP and urine protein of group A were lower than those of group B, with significant difference (t=5.077, 4.962; P<0.05) , but there were no significant differences on postpartum bleeding among four groups (t=0.259 7, 1.076 9, 1.518 5, P> 0.05) ．Compared with group A, the level of PT, APTT, Fg and DD of group B, group C and group D had significant differences (PT: t=5.255 6, 3.363 9, 4.882 0; P<0.05．APTT: t=2.311 2, 2.846 7, 3.686 6; P<0.05．Fg: t=5.671 4, 3.799 2, 20.824 7; P<0.05．DD: t=4.266 8, 9.720 1, 7.046 0; P<0.05) ．In addition, compared with group D, the level of TG, TC, apo-B of group A were decreased and the level of HDL and apo-A were increased, with significant differences (t=3.081 4, 2.889 1, 2.532 6, 1.717 0, 4.282 8, 2.207 6; P<0.05) ．There had significant differences of retinopathy incidence rated before and after the treatment in both group A and group B (χ²=3.172 0, 2.876 9; P<0.05) , and there had no significant differences in both group C and group D (χ² =1.124 9, 1.460 3; P>0.05) ．And compared with groups A, the retinopathy incidence rates of group B, C and D had no significant differences (χ² =0.341 6, 1.940 8, 1.804 7; P>0.05) ．Furthermore, the complication rate of group A were significant lower than that of group D (χ² =3.1344, P<0.05) , but there had no significant differences between group A and B, group A and group C (χ² =0.000 0, 2.181 9; P>0.05) .

The clinical effects of low molecular heparin calcium combined with salvia miltiorrhiza in the treatment of early onset severe preeclampsia are better than single medication.