Investigation of the Application Status of Antibacterial Drugs in Patients With Preoperative Gynecological and Obstetrical Surgery From a Third-Grade Class-A Hospital

doi:10.3877/cma.j.issn.1673-5250.2012.03.012

Objective

To investigate the application status of antibacterial drugs in patients with preoperative gynecological and obstetrical surgery from a third-grade class-A hospital.

Methods

A random sampling study was conducted on the use of antibacterial drugs in patients underwent obstetrical and gynecological surgery between June 2010 and June 2011 from a third-grade class-A hospital in Tianjin. Their clinical data were retrospectively analyzed in the aspects of drug combination, drug species, administration route, dose, frequency and dressing change.

Results

The single application rate of antibacterial drugs was 74.67% (224/300), rate of drug combination was 25.33% (76/300), rationality of the drug species was 88.67% (266/300), rationality of administration route was 100% (300/300), rationality of of dosage was 63.67% (191/300), and rationality of dressing change was 64.33% (193/300).

Conclusions

Management of antibacterial drugs administration for patients underwent gynecologic and obstetric operation should be strengthened in this third-grade class-A hospital in Tianjin.

Key words: gynecology and obstetrics, antibacterial drug, rational drug use, treatment programs

表1 围手术期患者抗菌药物治疗方案合理性评价标准

Table 1 Reasonable evaluation criteria of antibacterial drugs treatment programs for patients during perioperation

指标	合理	不合理
联合用药	有指征、有协同作用	无指征或有禁忌
单一用药	有指征	无指征
给药种类	合适	过高或不当
给药途径	正确	不正确
给药剂量	合适	过大或过少
给药次数	正确	不正确
换药理由	充分	不充分

表1 围手术期患者抗菌药物治疗方案合理性评价标准

Table 1 Reasonable evaluation criteria of antibacterial drugs treatment programs for patients during perioperation

指标	合理	不合理
联合用药	有指征、有协同作用	无指征或有禁忌
单一用药	有指征	无指征
给药种类	合适	过高或不当
给药途径	正确	不正确
给药剂量	合适	过大或过少
给药次数	正确	不正确
换药理由	充分	不充分

表2 抗菌药物联合应用情况(±s)

Table 2 The status of combination application of antibacterial drugs (±s)

二联用药品种	n	平均疗程(d)	应用率(%)
头孢西丁＋甲硝唑	29	5.6±3.3	9.67
头孢呋辛＋甲硝唑	25	5.7±3.2	8.33
美洛西林＋甲硝唑	8	4.3±1.7	2.67
头孢呋辛＋奥硝唑	7	5.0±1.7	2.33
青霉素钠＋甲硝唑	4	4.0±0.8	1.33
头孢硫脒＋奥硝唑	3	3.3±0.6	1.00

表2 抗菌药物联合应用情况(±s)

Table 2 The status of combination application of antibacterial drugs (±s)

二联用药品种	n	平均疗程(d)	应用率(%)
头孢西丁＋甲硝唑	29	5.6±3.3	9.67
头孢呋辛＋甲硝唑	25	5.7±3.2	8.33
美洛西林＋甲硝唑	8	4.3±1.7	2.67
头孢呋辛＋奥硝唑	7	5.0±1.7	2.33
青霉素钠＋甲硝唑	4	4.0±0.8	1.33
头孢硫脒＋奥硝唑	3	3.3±0.6	1.00

表3 围手术期患者抗菌药物应用方式合理性评价[n(%)]

Table 3 Reasonable assessment of the perioperative application of antimicrobial drugs [n(%)]

指标	合理	不合理
二联用药	44 (57.89)	32(42.11)
单一用药	300(100.00)	0 (0.00)
用药品种	266 (88.67)	34(11.33)
给药途径	300(100.00)	0 (0.00)
给药剂量	191 (63.67)	109(36.33)
给药次数	112 (37.33)	188(62.67)
换药理由	193 (64.33)	107(35.67)

表3 围手术期患者抗菌药物应用方式合理性评价[n(%)]

Table 3 Reasonable assessment of the perioperative application of antimicrobial drugs [n(%)]

指标	合理	不合理
二联用药	44 (57.89)	32(42.11)
单一用药	300(100.00)	0 (0.00)
用药品种	266 (88.67)	34(11.33)
给药途径	300(100.00)	0 (0.00)
给药剂量	191 (63.67)	109(36.33)
给药次数	112 (37.33)	188(62.67)
换药理由	193 (64.33)	107(35.67)

[1]	Miao XH. Problems in the clinical use of antibiotics and countermeasures[J]. Chin J Hosp Adm, 2005, 21(2):122-125.
[2]	Zhu SP, Gong J, Chang AH, et al. Clinical characteristics of perioperation of gynecological and obstetrical surgery in the grade Ⅲ-A general hospital[J]. Chin J Public Health, 2012, 28(3):412.
[3]	Zhu SP, Gong J, Hou HY, et al. Current Status of antimicrobial agents time of perioperation of gynecological and obstetrical surgery in the grade Ⅲ-A general hospital[J]. 2012, 28(4):504-505.
[4]	Wang X, Men K, Liu DH, et al. Analysis of antibiotic usage of hospitalized surgical patients[J]. Chin J Public Health, 2007, 22(6):710-711.
[5]	Infectious disease committee; Chinese Society of Obstetrics and Gynecology; Chinese Medical Association. Guide of antibiotic drugs in Obstetrics and Gynecology[J]. Chin J Obstet Gynecol, 2011, 46(3):230-233.
[6]	Shi HJ. Drug delivery program based on the concentration-dependent and time-dependent characteristics of antimicrobial drugs[J]. Herald Med, 2009, 28(9):1222-1223.

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