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Retinopathy of prematurity(ROP) is a leading cause of blindness in children all over the world nowadays. With increased survival rate of premature infants, the incidence of retinopathy of prematurity and the risk of disability have also increased remarkably. But current treatments cannot effectively intervene retinopathy of prematurity's prognosis at early stage, while some studies provide other promising targets for its drug treatment. This review focused on the mechanism and application of vascular endothelial growth factor (VEGF), insulin-like growth factor-1(IGF-1) and polyunsaturated fatty acids(PUFA) for early pharmaceutical treatment of retinopathy of prematurity.

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