The study of ginsenoside Rg3 on the expression of vascular endothelial growth factors in ectopic endometrium of rats

doi:10.3877/cma.j.issn.1673-5250.2006.02.105

Objective

To observe the effect of ginsenoside Rg3 on the expression of vascular endothelial growth factors(VEGF)and antiangiogenesis in ectopic endometrium of rats.

Methods

Wistar rats endometriosis models were established referring to Jones methods, the model rats were divided into the control group, ginsenoside Rg3 group, gestrinone group, each group were divided into 2 weeks, 4 weeks, 6 weeks and 8 weeks. VEGF was observed in ectopic endometrium by immunohistochemistry(SABC technique).

Results

VEGF in ectopic endometrium were decreased remarkably after treatment of ginsenoside Rg3 after 2, 4, 6, 8 weeks(P<0. 05), while the difference was not significant(P>0. 05)in the gestrinone group. And with the time prolonging, the expression of VEGF was reduced remarkably(P<0. 05)while the change was not observed in the control group and the gestrinone group.

Conclusion

Ginsenoside Rg3 has the effect on inhibiting the expression of VEGF and angiogenesis in ectopic endometrium of rats. Ginsenoside Rg3 maybe a new drug of antiangiogenesis in ectopic endometrium.

Key words: ginsenoside Rg3, endometriosis(EMs), Wistar rats, vascular endothelial growth factor(VEGF), angiogenesis

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