Chinese Medical E-ournals Database

Chinese Journal of Obstetrics & Gynecology and Pediatrics(Electronic Edition) ›› 2009, Vol. 05 ›› Issue (06): 590 -593. doi: 10.3877/cma.j.issn.1673-5250.2009.06.107

Original Article

Clinical Study on the Value of Mifepristone Combined With Rivanol Used in Induction of Labor in the Second Trimester for Scarred Uterus

Yu-bin HAN   

  1. Department of Obstetrics and Gynecology, Foshan First People's Hospital, Guangdong 528000, Guangdong Province, China
  • Published:2009-12-01
Objective

To evaluate the effect and security of mifepristone combined with rivanol used in the induction of labor in the second trimester for the scarred uterus.

Methods

From January 2005 to October 2008, 115 women asking for termination of second trimester pregnancy were randomized into two groups: observation group (n=64) and control group (n=51). Informed consent was obtained from all participates. Observation group were administered induced labor through amniotic injection of rivanol 100 mg before took mifepristone orally (150 mg), and the women in control group were administered routine induced labor through amniotic injection of rivanol 100 mg only. Duration of uterine contraction and uterine contraction, duration of uterine contraction and placental expulsion, pain grading, the amount of hemorrhage within 24 hours after the surgery, and cervical laceration were observed between observation group and control group.

Results

The rate of complete abortion in observation group (90.63%, 58/64) was higher than that of control group(70.59%, 36/51), which had significantly difference. The duration from injection to uterine contraction, duration from uterine contraction to placental expulsion of observation group [(26.71±10.73)h, (5.76±3.16) h] were shorter than those of control group [(36.28±12.35) h, (8.25±3.76) h](P<0.01). The rate of pain grading Ⅰ in observation group (42.19%, 27/64) was higher than that of control group (21.57%, 11/51) (P<0.01), and postpartum hemorrhage within 24 hours after the surgery in observation group [(103.29±26.72) mL] was less than that of control group [(141.36±82.51) mL](P<0.01). And the incident rate of cervical laceration of observation group (0, 0/64) was lower than that of control group (9.80%, 5/51)(P<0.01).

Conclusion

Mifepristone combined with rivanol used in the induction of labor in the second trimester for the scarred uterus is effective, safe, and simple.

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