To explore the clinical effects and safety of low dose of misoprostol combined with compound mifepristone tablets in treatment of induced labor in second pregnancy trimester.

From January 1, 2012 to December 31, 2015, a total of 80 cases of pregnant women who received induced labor in second pregnancy trimester in Oriental Hospital of Lianyungang were selected as research subjects. According to the random number table method, they were randomly divided into observation group (n=40) and control group (n=40). The pregnant women in observation group were given low dose of misoprostol combined with compound mifepristone tablets, while pregnant women in control group were treated with ethacridine combined with compound mifepristone tablets. The complete abortion rate, incomplete abortion rate, successful rate of induced labor, total induced labor time, vaginal hemorrhage volume and incidence of adverse reactions of two groups were statistically compared. There were no significant differences between two groups in maternal age, gestational age and parity (P>0.05). All pregnant women signed the informed consents before abortion.

①Compared with control group, the complete abortion rate in observation group was significantly increased and the difference was statistically significant (χ²=4.013, P=0.045). But there were no significant differences between two groups in incomplete abortion rate and successful rate of induced labor (P>0.05). ②Compared with control group, the total induced labor time in observation group was significantly shortened, the vaginal hemorrhage volume was significantly decreased, and both the differences were statistically significant (t=6.732, P=0.001; t=5.118, P=0.013). ③There were no significant differences between two groups in the rates of gastrointestinal reaction, hyperpyrexia reaction rate and liver function injury (P>0.05).

The clinical effect of low dose of misoprostol combined with compound mifepristone tablets in treatment of induced labor in second pregnancy trimester is good and safe without increasing the incidence of adverse reaction. As the sample size in this study is relatively small, induction effect and safety of low dose of misoprostol combined with compound mifepristone tablets, still need a large sample, multicenter, randomized controlled trials to further confirm.