Chinese Medical E-ournals Database

Chinese Journal of Obstetrics & Gynecology and Pediatrics(Electronic Edition) ›› 2009, Vol. 05 ›› Issue (05): 488 -492. doi: 10.3877/cma.j.issn.1673-5250.2009.05.107

Original Article

Effects of Transvaginal Color Doppler Ultrasound Measurements on Microvessel Density Assessment in Ovarian Tumors

Su-juan HE, Ying-hua WANG   

  1. Department of Obstetrics and Gynecology, Shanxi Medical University First Hospital, Taiyuan 030001, Shanxi Province, China
  • Published:2009-10-01
Objective

To explore the dependability between transvaginal color Doppler ultrasound(TV-CDU) vascular blood flow indices and microvessel density (MVD) in ovarian tumor.

Methods

From January 2004 to December 2005, transvaginal color and pulsed Doppler ultrasound sonography were performed before surgical procedure in 82 women with ovarian tumors. Blood flow indices [pulsatility index (PI), resistive index (RI), peak systolic velocity(Vps), vessels number(VN)] were measured. Microvessel density was identified by Immunohistochemical staining of endothelial cell for CD34.

Results

There were statistically significant differences in microvessel density between histopathology rank of ovarian cancer. Also, a significant correlation was found between microvessel density and low resistance to blood flow as measured by the resistive index or vessels number (P<0.05). However, no statistically significant correlation was found between microvessel density and pulsatility index or peak systolic velocity. The differences of resistive index and vessels number in benign and malignant ovarian tumor or lymph node metastases group and non-lymph node metastases group of ovarian cancer were statistically significant (P<0.01), but no statistically significant differences were found between International Federation of Gynecology and Obstetrics (FIGO) stage Ⅰ and other stages (P>0.05). Statistically significant differences in vessels number were found between histopathology ranks, but resistive index was not found.

Conclusion

Low resistive index and high vessels number may reflect high microvessel density in ovarian cancer and correlate with its histopathology rank and lymph node metastases.

图1 CD34免疫组化染色肿瘤间质内可见数个大小不等的呈棕黄色染色的微血管(×100)
图2 浆液性乳头状囊腺癌血流及其频谱(与图1为同1例患者)
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