A Study on the Expression and Clinical Significance of AIB1 Protein in Ovarian Borderline Epithelial Tumor

doi:10.3877/cma.j.issn.1673-5250.2008.03.105

Objective

To investigate the expression and clinical significance of AIB1(amplified in breast cancer 1) protein in ovarian borderline epithelial tumor.

Methods

We examined the AIB1 expression levels and its relations to clinicopathological features in 24 normal ovaries, 24 cases of ovarian benign epithelial tumor, 18 cases of ovarian borderline epithelial tumor and 69 cases of epithelial ovarian cancer by immunohistochemical method SP. We also simultaneously examined the expression of estrogen receptor (ER), progesterone receptor(PR), p53 protein and bcl-2 protein in ovarian borderline epithelial tumors.

Results

①The positive expression rate of AIB1 protein in ovarian borderline epithelial tumors was 38.89%, which was significantly lower than that in ovarian cancers (65.22%), higher than that in normal ovaries(8.33%), but the difference between the borderline and benign ovarian tumors was not significant. ②The expression of AIB1 protein in clinical stageⅡ~Ⅲ was higher than that in stageⅠ, but the expression levels in different histological groups were not significant. ③AIB1 protein expression was positively correlated with estrogen receptor, progesterone receptor, p53 protein, but there was no correlation between expressions of AIB1 and bcl-2 protein.

Conclusion

The expression of AIB1 may play a role in the ovarian carcinogenesis of the borderline epithelial tumor through steroid receptor and mutational p53 protein signal transduction pathways.

Key words: ovarian tumor, borderline tumor, AIB1 protein, immunohistochemistry

	1　Kuang SQ, Liao L, Wang S, et al. Mice lacking the amplified in breast cancer 1/steroid receptor coactivator－3 are resistant to chemical carcinogen－induced mammary tumorigenesis. Cancer Res，2005，65(17)：7993－8002.
	2　韩肖燕，郄明蓉，张雪梅等. AIB1蛋白在妇科肿瘤中的表达. 四川大学学报(医学版)，2007，38(2)：246－249.
	3　曹泽毅主编. 中华妇产科学下册．第2版. 北京：人民卫生出版社，2005，1908－1909.
	4　Henke RT, Haddad BR, Kim SE, et al. Overexpression of the nuclear receptor coactivator AIB1 (SRC－3) during progression of pancreatic adenocarcinoma. Clin Cancer Res, 2004, 10(18 Pt 1): 6134－6142.
	5　王建六，张岫屏，魏丽惠. 卵巢上皮性肿瘤雌、孕激素受体亚型的初步研究. 中国肿瘤临床，2002, 29(7)：457－460.
	6　倪灿荣，马大烈，戴益民主编. 免疫组织化学实验技术及应用. 北京：化学工业出版社，2006, 323.
	7　Anzick SL, Kononen J, Walker RL, et al. AIB1, a steroid receptor coactivator amplified in breast and ovarian cancer. Science, 1997, 277(5328): 965－968.
	8　Liao L, Kuang SQ, Yuan Y, et al. Molecular structure and biological function of the cancer－amplified nuclear receptor coactivator SRC－3/AIB1. J Steroid Biochem Mol Biol, 2002, 83(1－5)：3－14.
	9　Font de Mora J, Brown M. AIB1 is a conduit for kinase－mediated growth factor signaling to the estrogen receptor. Mol Cell Biol, 2000, 20(14): 5041－5047.
	10　Sarraf S, Tejada R, Abawi M, et al. The human ovarian teratocarcinoma cell line PA－1 demonstrates a single translocation: Analysis with fluorescence in situ hybridization, spectral karyotyping, and bacterial artificial chromosome microarray. Cancer Genet Cytogenet, 2005, 161(1): 63－69.
	11　Tanner MM, Grenman S, Koul A, et al. Frequent amplification of chromosomal region 20q12－q13 in ovarian cancer. Clin Cancer Res, 2000, 6(5): 1833－1839.
	12　郎景和主编. 妇科手术笔记．第2卷. 北京：中国科学技术出版社，2004，36.
	13　Bouras T, Southey MC, Venter DJ. Overexpression of the steroid receptor coactivator AIB1 in breast cancer correlates with the absence of estrogen and progesterone receptors and positivity for p53 and HER2/neu. Cancer Res, 2001, 61(3)：903－907.
	14　Zhou HJ, Yan J, Luo W, et al. SRC－3 is required for prostate cancer cell proliferation and survival. Cancer Res，2005, 65(17): 7976－7983.

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