Chinese Medical E-ournals Database

Chinese Journal of Obstetrics & Gynecology and Pediatrics(Electronic Edition) ›› 2006, Vol. 02 ›› Issue (06): 315 -317,f2. doi: 10.3877/cma.j.issn.1673-5250.2006.06.104

Original Article

The study of E-cadherin and CD44 varient 6 on pathogenesis in human adenomyosis

Jia-li KANG, Chun-xiang GUAN, Xiao-hui HUANG, Xiao-xia WANG, Wei XIA, Miao-ling NIE   

  1. Department of Gynaecology and obstetrics, The First Hospital of Guangzhou, Guangzhou Medical College, Guangdong, 510180, China
  • Published:2006-11-21
Objective

To observe the expression of E-cadherin and CD44 v6 in human adenomyosis.To explore the correlation between the expression of E-cadherin and CD44 v6 in the pathogenesis of adenomyosis.

Methods

The expression of E-cadherin and CD44v6 in 50 ectopic and eutopic endometrium of adenomyosis was detected by immunohistochemical method in comparison with 30 normal endometrium.

Results

were analyzed by SPSS13.0 statistical software.Results The expression of E-cadherin in ectopic and eutopic endometrium of adenomyosis is lower than that in normal endometrium(P <0.05).The expression of CD44v6 in ectopic and eutopic endometrium of adenomyosis is higher than that in normal endometrium(P<0.05).There was a negative correlation between the expression of E-cadherin and CD44 v6 in eutopic endometrium of adenomyosis and ectopic endometrium of adenomyosis(P<0.05).There was no correlation between the expression of E-cadherin and CD44v6 in normal endometrium(P>0.05).

Conclusion

The abnormal expression of E-cadherin and CD44 v6 in eutopic endometrium and ectopic endometrium has relationship with the etiology of adenomyosis.

图1 E-cadherin在正常子宫内膜中的强阳性表达 × 100
图2 E-cadherin在AM患者在位子宫内膜中的阳性表达 × 100
图3 E-cadherin在AM患者异位内膜中的弱阳性表达 ×200
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