The study of E-cadherin and CD44 varient 6 on pathogenesis in human adenomyosis

doi:10.3877/cma.j.issn.1673-5250.2006.06.104

Objective

To observe the expression of E-cadherin and CD₄₄ v6 in human adenomyosis.To explore the correlation between the expression of E-cadherin and CD₄₄ v6 in the pathogenesis of adenomyosis.

Methods

The expression of E-cadherin and CD₄₄v6 in 50 ectopic and eutopic endometrium of adenomyosis was detected by immunohistochemical method in comparison with 30 normal endometrium.

Results

were analyzed by SPSS13.0 statistical software.Results The expression of E-cadherin in ectopic and eutopic endometrium of adenomyosis is lower than that in normal endometrium(P <0.05).The expression of CD₄₄v6 in ectopic and eutopic endometrium of adenomyosis is higher than that in normal endometrium(P<0.05).There was a negative correlation between the expression of E-cadherin and CD₄₄ v6 in eutopic endometrium of adenomyosis and ectopic endometrium of adenomyosis(P<0.05).There was no correlation between the expression of E-cadherin and CD₄₄v6 in normal endometrium(P>0.05).

Conclusion

The abnormal expression of E-cadherin and CD₄₄ v6 in eutopic endometrium and ectopic endometrium has relationship with the etiology of adenomyosis.

Key words: E-cadherin, CD₄₄ varient 6(CD₄₄v6), adenomyosis, immunohistochemistry

图1 E-cadherin在正常子宫内膜中的强阳性表达　× 100

图2 E-cadherin在AM患者在位子宫内膜中的阳性表达　× 100

图3 E-cadherin在AM患者异位内膜中的弱阳性表达　×200

	1　乐杰主编.妇产科学.第6版.北京：人民卫生出版社，2005,361.
	2　连利娟主编.林巧稚妇科肿瘤学.第3版.北京：人民卫生出版社，2001,733-738.
	3　Sillem M，Hahn U, Coddington CC，et al.Ectopic growth of endometrium depends on its structural integrity and proteolytic antivity in the cynomolgus monkey(Macaca fascicularis)model of endometriosis.Fertil Steril, 1998, 66(3)：468-473.
	4　郎景和主编.子宫内膜异位症的基础与临床研究.北京：中国协和医科大学出版社，2003,171.
	5　Handschuh G，Candidus S，Luber B，et al.Tumor-associated E-cadherin mutations alter celluar morphology, decrease celluar adhesion and increase celluar motility.Oncogene，1999，18(30): 4301-4312.
	6　Zohar R，Suzuki N，Suzuki K，et al.Intracelluar osteopontin is an integral companent of the CD44-ERM complex involced in cell migration.Cell.Physiol, 2000 ，184:118-130.
	7　郭立霞，谢弘.CD44与肿瘤转移.生命科学，2001，13(2):61-63.
	8　Yu Q，Stamenkovic I.Cell surface-Localized matrix metalloproteinase-9 proteolytically active TGF-β and promotes tumor invasion and angiogenesis.Genes Dev，2000，14:163-176.

[1]	Yang Zhao, Yingcong Xiao, Yan Ju, Xiaozhi Dang, Linli Cai, Wenxin Xue, Yang Li, Yao Xiao, Yuqi Guo, Hongping Song. Clinical value of automated breast ultrasound combined with immunohistochemistry in early prediction of pathological complete response to neoadjuvant chemotherapy in breast cancer[J]. Chinese Journal of Medical Ultrasound (Electronic Edition), 2024, 21(04): 361-369.
[2]	Zhuangzhuang Wu, Xiaojuan Zhang, Zehong Shi, yao Shi, Shaoling Yuan. Prognostic value of ultrasound combined with mammography and PR and HER-2 status in high-grade and middle-low-grade ductal carcinoma in situ of the breast[J]. Chinese Journal of Medical Ultrasound (Electronic Edition), 2023, 20(06): 631-635.
[3]	Yuanyuan He, Jia Li, Hong Yang. Mesonephric adenocarcinoma of uterine cervix: a case report and literature review[J]. Chinese Journal of Obstetrics & Gynecology and Pediatrics(Electronic Edition), 2024, 20(01): 97-104.
[4]	Xingchen Liu, Juan Liu, Baobao Wei, Jie Liu, Hui Liu. Correlation analysis of abnormal expression of XIAP and XAF1 with ovarian cancer[J]. Chinese Journal of Obstetrics & Gynecology and Pediatrics(Electronic Edition), 2023, 19(04): 419-427.
[5]	Chunying Han, Tingting Wang, Yanyan Li, Jinxia Piao. Current research status on predictors of lymphatic vascular invasion in patients with endometrial carcinoma[J]. Chinese Journal of Obstetrics & Gynecology and Pediatrics(Electronic Edition), 2023, 19(04): 403-409.
[6]	Yifang Chen, Xiaohui Huang. Expression and clinical significance of paraoxonase 2 in hepatocellular carcinoma[J]. Chinese Archives of General Surgery(Electronic Edition), 2024, 18(03): 186-191.
[7]	Ningning Hu, Yanrong Zhao, Dong Wang, Shengliang Wang, Yuan Guo. The correlation study between the expression of FMNL3 and prognosis in hepatocellular carcinoma liver transplant recipients[J]. Chinese Journal of Transplantation(Electronic Edition), 2024, 18(05): 283-288.
[8]	Qinliang Si, Shilong Bi, Huixiao Jiao, Shizhao Li, Zheyu Chen, Yudong Wu. Two cases of dedifferentiated liposarcoma of spermatic cord and literature review[J]. Chinese Journal of Endourology(Electronic Edition), 2024, 18(06): 585-590.
[9]	Jing Wang, Jianjian Gao, Ping Liu, Meirong Lu, Yongxing Yuan, Xi Hu, Liangliang Sun, Junliang Li, Hailin Wang. Analysis of the da Vinci robotic laparo-endoscopic single site surgery for benign gynecological diseases[J]. Chinese Journal of Laparoscopic Surgery(Electronic Edition), 2023, 16(06): 342-347.
[10]	Chenglei Gu, Jia Xu, Nina Zhang, Luyang Zhao, Wensheng Fan. Application of robotic-assisted surgery in difficult hysterectomy[J]. Chinese Journal of Laparoscopic Surgery(Electronic Edition), 2023, 16(05): 283-287.
[11]	Ruiyi Tan. Current advances and developments in diagnosis and treatment of small cell osteosarcoma[J]. Chinese Journal of Clinicians(Electronic Edition), 2024, 18(08): 781-784.
[12]	Ruixue Yue, Lingxin Kong, Xin Hao, Jinqiang Yang, Meng Han, Guozhong Cui, Jianjun Wang, Zhisheng Zhang, Fanting Kong, Wei Zhang, Wenbo He, Xianqiao Li, Xinping Zhou, Donghong Xu, Chongzhu Hu. HER2 protein expression levels predict efficacy of neoadjuvant therapy in breast cancer: A real-world study[J]. Chinese Journal of Clinicians(Electronic Edition), 2023, 17(07): 765-770.
[13]	Wenbo Niu, Fengpeng Wu, Yueping Liu, Chaoxi Zhou, Juan Zhang, Xuhua Hu, Baokun Li, Gueying Wang. Neoadjuvant chemoradiotherapy for treatment of locally advanced rectal cancer: Efficacy and tumor immune microenvironment changes[J]. Chinese Journal of Clinicians(Electronic Edition), 2023, 17(05): 519-523.
[14]	Gaocai Mao, Jianbo Zhang, Yifang Yuan, Xiaobo Mao, Huiyong Dai, Zhe Wang. Diagnostic characteristics of clear cell type oxyphilic adenoma of salivary gland in retroauricular lymph nodes[J]. Chinese Journal of Diagnostics(Electronic Edition), 2023, 11(04): 261-265.
[15]	Ying Liu, Man Yin, Linqing Yang, Yunfei Wang. Diagnostic characteristics of invasive stratified mucin-producing carcinoma and literature review[J]. Chinese Journal of Diagnostics(Electronic Edition), 2023, 11(03): 173-177.

Viewed

Full text

Abstract

Please choose a citation manager

Content to export

The study of E-cadherin and CD₄₄ varient 6 on pathogenesis in human adenomyosis

模态框（Modal）标题

Please choose a citation manager

Content to export

The study of E-cadherin and CD44 varient 6 on pathogenesis in human adenomyosis

The study of E-cadherin and CD₄₄ varient 6 on pathogenesis in human adenomyosis